Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of degradation acidity-adjustable self-enhanced polyester/ordered mesoporous degradable bone repair material as well as product and application thereof

A mesoporous material and adjustable technology, applied in the field of biomedical composite materials, can solve the problems of acidity and poor mechanical properties of degradation products, and achieve the effects of overcoming molecular weight loss, improving mechanical properties, and easy processing and molding.

Inactive Publication Date: 2019-01-08
SHANGHAI NAT ENG RES CENT FORNANOTECH
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the poor mechanical properties of the existing polyester-based bone repair materials and the acidity of the degradation products, the purpose of the present invention is to provide a self-reinforced polyester / ordered mesoporous polymer with adjustable degradation acidity. Preparation method of degradable bone repair material

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of degradation acidity-adjustable self-enhanced polyester/ordered mesoporous degradable bone repair material as well as product and application thereof
  • Preparation method of degradation acidity-adjustable self-enhanced polyester/ordered mesoporous degradable bone repair material as well as product and application thereof
  • Preparation method of degradation acidity-adjustable self-enhanced polyester/ordered mesoporous degradable bone repair material as well as product and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] First, the MCM-41 mesoporous material was evacuated and dried at 120 °C for 24 hours to remove the moisture adsorbed in the mesoporous channels. Weigh 1 g of dried MCM-41 and add it to 35 mL of DMF, put it into a three-necked flask that removes water and oxygen, add 1 g of 3-aminopropyltriethoxysilane (APTES) under nitrogen protection and magnetic stirring ), reflux reaction at 80 °C for 12 hours, the product was filtered, washed with a large amount of ethanol and dried to obtain amino-modified MCM-41, denoted as H 2 N-MCM-41. 5 g of lactide was dissolved in 120 ℃, 20 mL of toluene solvent with dehydration and oxygen removal, and the dried 1 g of NH 2 -MCM-41 and 0.0016 mL Sn(Oct) 2 Add it into a single-necked flask, heat it to 90 °C in 20 mL of toluene solvent that removes water and oxygen, and stir evenly, then add it dropwise to the lactide solution under nitrogen protection and magnetic stirring, and react at 120 °C 24 hours. When the above reaction mixture was c...

Embodiment 2

[0044] First, the MCM-41 mesoporous material was evacuated and dried at 120 °C for 24 hours to remove the moisture adsorbed in the mesoporous channels. Weigh 1 g of dried MCM-41 and add it to 35 mL of DMF, put it into a three-necked flask that removes water and oxygen, add 1 g of 3-aminopropyltriethoxysilane (APTES) under nitrogen protection and magnetic stirring ), reflux reaction at 80 °C for 12 hours, the product was filtered, washed with a large amount of ethanol and dried to obtain amino-modified MCM-41, denoted as H 2 N-MCM-41. 5 g of lactide was dissolved in 120 ℃, 20 mL of toluene solvent with dehydration and oxygen removal, and the dried 1 g of NH 2 -MCM-41 and 0.0016 mL Sn(Oct) 2 Add it into a single-necked flask, heat it to 90 °C in 20 mL of toluene solvent that removes water and oxygen, and stir evenly, then add it dropwise to the lactide solution under nitrogen protection and magnetic stirring, and react at 120 °C 24 hours. When the above reaction mixture was c...

Embodiment 3

[0047] First, the MCM-41 mesoporous material was evacuated and dried at 120 °C for 24 hours to remove the moisture adsorbed in the mesoporous channels. Weigh 1 g of dried MCM-41 and add it to 35 mL of DMF, put it into a three-necked flask that removes water and oxygen, add 1 g of 3-aminopropyltriethoxysilane (APTES) under nitrogen protection and magnetic stirring ), reflux reaction at 80 °C for 12 hours, the product was filtered, washed with a large amount of ethanol and dried to obtain amino-modified MCM-41, denoted as H 2 N-MCM-41. 5 g of lactide was dissolved in 120 ℃, 20 mL of toluene solvent with dehydration and oxygen removal, and the dried 1 g of NH 2 -MCM-41 and 0.0016 mL Sn(Oct) 2 Add it into a single-necked flask, heat it to 90 °C in 20 mL of toluene solvent that removes water and oxygen, and stir evenly, then add it dropwise to the lactide solution under nitrogen protection and magnetic stirring, and react at 120 °C 24 hours. When the above reaction mixture was c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation method of a degradation acidity-adjustable self-enhanced polyester / ordered mesoporous degradable bone repair material as well as a product and application thereof. The self-enhanced and degradation acidity-adjustable composite material is prepared by taking a degradable polyactic acid-based ternary random copolymer as a matrix and a modified ordered mesoporeas an enhancer. The preparation method comprises preparation of a PLLA surface modified MCM-41 mesoporous silicon oxide and preparation of a polyester / PLLA-NH-MCM-41 composite material. In the productobtained by the method, the mesoporous materials are dispersed uniformly into an organic matrix, the two-phase interface compatibility is high, the mechanical property of the polyester base is greatly improved and the pH can be maintained in a neutral range in a degradation process. The obtained product can meet the requirement of clinical application. The preparation process is simple and controllable, small in adding amount of nanometer materials and easy to process and form; and the product has high mechanical strength and stable performance and can serve as a bone repair material of a weight-bearing bone part with relatively high requirements on properties and indexes.

Description

technical field [0001] The invention relates to a preparation method of a self-reinforced polyester / ordered mesoporous degradable bone repair material with adjustable degradation acidity, its product and application, and belongs to the field of biomedical composite materials. Background technique [0002] Polylactic acid is the first natural synthetic polymer used in bone defect repair since 1986. However, due to its long degradation cycle, it has been used as an improvement of polylactic acid in recent years. Polylactic acid and its copolymers such as polylactic acid-glycolic acid ( PLGA), polylactic acid-caprolactone (PLA-PCL), polylactic acid-trimethylene carbonate-glycolide (PLTG) have been extensively studied. Although these polylactic acid-based copolymers have good degradable absorbability and biocompatibility, there are still many problems in the application of a single organic polymer to biomaterials, especially bone repair scaffold materials. For example, as a sca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/44C08G83/00
CPCA61L27/446A61L27/50A61L27/58A61L2430/02C08G83/001C08L67/04
Inventor 何丹农王杰林王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com