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Drug-loaded structure of titanium metal surface pH controlled-release drug and preparation method of drug-loaded structure

A titanium metal, drug-carrying technology, applied in the field of material science and nanomaterials, can solve the problems of human body influence, the inability of antibiotics to intelligently controlled release, etc., to achieve the effect of less resource consumption, less difficulty in implementation, and improved antibacterial properties

Inactive Publication Date: 2019-01-08
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main treatment for bacterial infection is to inject antibiotics into the body. However, since antibiotics enter the human body and cannot be released under intelligent control, it will cause unnecessary impact on the human body. Therefore, it is very necessary to develop an intelligent drug delivery system. , especially on metal surfaces of bone implants

Method used

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  • Drug-loaded structure of titanium metal surface pH controlled-release drug and preparation method of drug-loaded structure
  • Drug-loaded structure of titanium metal surface pH controlled-release drug and preparation method of drug-loaded structure
  • Drug-loaded structure of titanium metal surface pH controlled-release drug and preparation method of drug-loaded structure

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Experimental program
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Effect test

Embodiment 1

[0025] A drug-loaded structure with pH-controlled drug release on the surface of titanium metal and a preparation method thereof, characterized in that it comprises the following steps:

[0026] Step 1: After grinding the titanium metal with a diameter of 5.5-6.5mm and a thickness of 2.0-3.0mm with sandpaper step by step, then ultrasonically clean it in acetone, deionized water, and absolute ethanol in sequence, and perform anodic oxidation treatment after drying to prepare titanium dioxide nanotubes ;

[0027] Step 2: Disperse 100 mg of zinc oxide quantum dots in dimethylformamide, add 20 mL of 3-aminopropyltriethoxysilane, and stir at 90° C. for 15 minutes to obtain a mixture containing aminated zinc oxide quantum dots; 1 mg of folic acid was dissolved in 0.5 mL of dimethyl sulfoxide, 1 mg of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride was added and stirred for 30 min to obtain a mixed solution, and the mixed The solution was added to the mixture containing z...

Embodiment 2

[0033] A drug-loaded structure with pH-controlled drug release on the surface of titanium metal and a preparation method thereof, characterized in that it comprises the following steps:

[0034] Step 1: After grinding the titanium metal with a diameter of 5.5-6.5mm and a thickness of 2.0-3.0mm with sandpaper step by step, then ultrasonically clean it in acetone, deionized water, and absolute ethanol in sequence, and perform anodic oxidation treatment after drying to prepare titanium dioxide nanotubes ;

[0035] Step 2: Disperse 100 mg of zinc oxide quantum dots in dimethylformamide, add 20 mL of 3-aminopropyltriethoxysilane, and stir at 90° C. for 15 minutes to obtain a mixture containing aminated zinc oxide quantum dots; 2 mg of folic acid was dissolved in 0.5 mL of dimethyl sulfoxide, 1 mg of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride was added and stirred for 30 min to obtain a mixed solution, and the mixed The solution was added to the mixture containing z...

Embodiment 3

[0041] A drug-loaded structure with pH-controlled drug release on the surface of titanium metal and a preparation method thereof, characterized in that it comprises the following steps:

[0042] Step 1: After grinding the titanium metal with a diameter of 5.5-6.5mm and a thickness of 2.0-3.0mm with sandpaper step by step, then ultrasonically clean it in acetone, deionized water, and absolute ethanol in sequence, and perform anodic oxidation treatment after drying to prepare titanium dioxide nanotubes ;

[0043] Step 2: Disperse 100 mg of zinc oxide quantum dots in dimethylformamide, add 20 mL of 3-aminopropyltriethoxysilane, and stir at 90° C. for 15 minutes to obtain a mixture containing aminated zinc oxide quantum dots; The folic acid of 5mg is dissolved in the dimethylsulfoxide of 0.5mL, the 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride of 1mg is added and stirred for 30min to obtain a mixed solution, and the mixed The solution was added to the mixture contain...

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Abstract

The invention discloses a drug-loaded structure of a titanium metal surface pH controlled-release drug and a preparation method of the drug-loaded structure. The structure comprises a titanium dioxidenanotube grown on the surface of titanium metal and a composite coating encapsulated on the surface of the titanium dioxide nanotube and containing folic acid and zinc oxide quantum dots; the preparation method comprises the following steps: after treating the titanium metal, allowing titanium dioxide nanotube to grow on the surface of the titanium metal by anodic oxidation, then loading a drug into the tube, and encapsulating the titanium dioxide nanotube with the prepared composite containing the folic acid and the zinc oxide quantum dots. According to the invention, the folic acid and a zinc oxide quantum dot coating in the drug-loading structure disclosed by the invention can control drug release in response to the pH, the slow release of zinc oxide in an acidic environment enhances an antibacterial cycle, the addition of the folic acid can promote cell proliferation and differentiation and facilitate the healing of a bacterial infection area, and both the folic acid and zinc oxide can be degraded in a human body, therefore, the drug-loading structure is harmless to a human body. The preparation method disclosed by the invention is simple, easy to operate and less in resourceconsumption, and has no influence on the environment.

Description

technical field [0001] The invention relates to the technical fields of material science and nanometer materials, in particular to a drug-loading structure and a preparation method thereof for pH-controlled release of drugs on the surface of titanium metal. Background technique [0002] Biomedical material is an important branch of material science; it is a new type of carrier material with high technical content and high economic value for diagnosis, treatment or replacement of human tissue, organ or enhancement of its function; it is a developing field in material science and technology. In the new field, biomedical materials have made and will soon make outstanding contributions to exploring the mysteries of human life and ensuring human health and longevity. Among biomedical metal materials, titanium and its alloys are widely used in artificial joints (hip, knee, shoulder, ankle, elbow, wrist, knuckles, etc.), orthopedic trauma products (intramedullary nails, plates, scr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/54A61L31/02A61L31/08A61L31/16C25D11/26
CPCA61L27/06A61L27/306A61L27/54A61L31/022A61L31/088A61L31/16A61L2300/102A61L2300/404A61L2300/602A61L2420/06A61L2420/08C25D11/26
Inventor 吴水林向一鸣刘想梅
Owner HUBEI UNIV
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