Production raw material of liquid ventilation fluid and material for ophthalmic surgery and continuous preparation method of production raw material

Abstract

The invention provides a production raw material of liquid ventilation fluid and a material for an ophthalmic surgery and a continuous preparation method of the production raw material. The productionraw material comprises fluorine and an octane organic matter, the molar ratio of the fluorine to the octane organic matter is 20: 1-25: 1, the fluorine is mixed gas of pure fluorine or fluorine and inert gas, and the concentration of the fluorine is not lower than 10%; and the octane organic matter is a mixture of octane, an octane homologue or a mixture of the octane organic matter and inert gas. The production raw material is suitable for being produced continuously on a large scale, reaction conditions are easy to control, the yield is high, by-products are less, reaction products are easyto separate and purify, and waste gas, waste water and solid wastes are not discharged in a production process. By the method of the invention, perfluorooctane of which the purify is greater than orequal to 99% can be prepared, and can serve as the production raw material of liquid ventilation fluid and a preparation for the ophthalmic surgery.

Description

Technical field [0001] The invention relates to the technical field of perfluorooctane preparation methods, in particular to the production raw materials of liquid ventilation fluids and materials for ophthalmic surgery and a continuous preparation method thereof. Background technique [0002] In the past, perfluorooctane preparation methods include cobalt trifluoride fluorination method and electrolytic fluorination method. The cobalt trifluoride method requires the first fluorination of the cobalt difluoride to convert it into cobalt trifluoride, and the cobalt trifluoride reacts with octane in the reactor to obtain a mixture containing perfluorooctane; the cobalt trifluoride needs to be continuously regenerated , The temperature of the reactor is difficult to control uniformly, the scale-up is limited, the production cannot be carried out continuously, and it is not suitable for mass production. In addition, the electrolytic fluorination method for synthesizing perfluorooctan...

AI Technical Summary

Problems solved by technology

The cobalt trifluoride method needs to convert cobalt difluoride into cobalt trifluoride by fluorination first, and then cobalt trifluoride reacts with octane in the reactor to obtain a mixture containing perfluorooctane; cobalt trifluoride needs to be continuously regenerated , the reactor temperature is difficult to control uniformly, the scale-up is limited, the production cannot be carried out continuously, and it is not suitable for mass production

In addition, the electrolytic fluorination method to synthesize perfluorooctane has complex equipment, difficult condition control, many by-products, and low yield, which generally does not exceed 15%.

[0003] Publication (Announcement) No.: CN104926597A patent discloses a preparation method of perfluorooctane, which includes the following steps: (1) filling a catalyst in the reactor, and performing fluorination treatment at high temperature with a fluorinating agent; (2) Add octane to the vaporizer to obtain octane vapor, and control the temperature of the vaporizer between 100 and 150°C; (3) Pass inert gas into the vaporizer to dilute the octane vapor, and continuously pass the octane vapor diluted mixture into The reactor and the fluorinating agent undergo a fluorination substitution reaction; (4) The reaction product is purified by alkali washing, water washing, and rectification to obtain perfluorooctane; improve