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Chinese herbal medicine compound preparation for regulating intestinal tract barrier function and preparation method thereof

A technology of intestinal barrier function and compound preparations, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of inevitability, toxicity and side effects, and achieve the reduction of the formation of the microenvironment and the control of tumors Size, medicinal properties and mild effect

Active Publication Date: 2019-01-01
SHANGHAI TCM INTEGRATED HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemotherapy drugs inevitably have considerable toxic side effects on the body, among which intestinal barrier damage is the toxic response of some anticancer drugs

Method used

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  • Chinese herbal medicine compound preparation for regulating intestinal tract barrier function and preparation method thereof
  • Chinese herbal medicine compound preparation for regulating intestinal tract barrier function and preparation method thereof
  • Chinese herbal medicine compound preparation for regulating intestinal tract barrier function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Experimental research on the protection of intestinal barrier, regulation of PI3K / AKT expression and inhibition of metastasis by traditional Chinese medicine compound preparation of the present invention 1. Animals: 65 BALB / c female nude mice aged 4 to 5 weeks, 30 NOD-SCID mice, Thirty BALB / c nude mice, weighing 20-24 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd., Chinese Academy of Sciences, and were raised in an SPF environment. The experimental animal qualification certificate number: SYXK (Shanghai) 2014-0008.

[0027] 2. Method:

[0028] 2.1 Cell culture and subcutaneous tumor transplantation

[0029] CT26.WT cells were cultured in DMEM medium. When the cells grew to 70%-80% confluent, they were digested and passaged with 0.25% trypsin and 0.02% EDTA solution. After counting, they were diluted to a cell number of 1.25×107ml-1. After the skin of each nude mouse was disinfected, 0.2mL of cell suspension was injected subcutaneously at ...

Embodiment 2

[0069] Embodiment 2 The curative effect comparison of the present invention and Changyi decoction

[0070] 1. Animals: 20 BALB / c nude mice aged 4 to 5 weeks, weighing 20 to 24 g, purchased from Shanghai Slack Experimental Animal Co., Ltd., Chinese Academy of Sciences, raised under SPF environment, experimental animal qualification certificate number: SYXK (Shanghai) 2014-0008.

[0071] 2. Method:

[0072] 2.1 Cell culture and subcutaneous tumor transplantation

[0073] The method is the same as animal experiment 1

[0074] 2.2 Screening of high-metastasis model of mouse colon cancer subcutaneously transplanted ["Screening and establishment of high-metastasis model of mouse colon cancer in vivo"]

[0075] The method is the same as animal experiment 1

[0076] 2.3 Orthotopic inoculation of subcutaneous transplanted tumors

[0077] The method is the same as animal experiment 1

[0078] 2.4 Grouping and administration method

[0079] 24 hours after orthotopic inoculation (d...

Embodiment 3

[0087] Embodiment 3 clinical trial research

[0088] 1. Case selection:

[0089] During the period from June 2017 to March 2018, patients who were diagnosed with colorectal cancer in the Xinhua Hospital Affiliated to Shanghai Jiaotong University, and patients diagnosed with colorectal cancer in our hospital (Shanghai Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine) were selected. Patients, a total of 60 cases, all patients received chemotherapy during this period.

[0090]Western medicine diagnosis was made according to the diagnostic criteria in the "CSCO Guidelines for the Diagnosis and Treatment of Colorectal Cancer" (2016 edition) of the Chinese Society of Clinical Oncology. TNM pathological staging (pTNM) adopts AJCC / UICC 7th edition [8], see "2.4 Staging of colorectal cancer" for details.

[0091] According to the "Guiding Principles for Clinical Research of Traditional Chinese Medicine T...

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Abstract

The invention relates to a Chinese herbal medicine compound preparation for regulating intestinal tract barrier function and regulating body immunity of cancer patients and a preparation method thereof. The Chinese herbal medicine compound preparation is prepared from the following raw traditional Chinese medicines: 30-45 parts of radix astragali, 10-30 parts of radix codonopsis pilosulae, 10-20 parts of poria cocos, 10-20 parts of white atractylodes rhizome, 10-15 parts of rhizoma smilacis glabrae, 10-30 parts of chinaroot greenbrier rhizome, 10-20 parts of akebia trifoliata koidz fruit, 5-20parts of endothelium corneum gigeriae galli and 10-30 parts of Chinese actinidia root. The Chinese herbal medicine compound preparation provided by the invention has the effects of tonifying qi and spleen, resolving dampness and removing stasis; for the cancer patients with the primary symptom of spleen deficiency caused by chemotherapy, the Chinese herbal medicine compound preparation has the effects of protecting against intestinal tract barrier damage and promoting the life quality of the patients; the Chinese herbal medicine compound preparation is low in cost, is safe and effective, is free from toxic and side effects, is capable of adjusting PI3K / AKT expression in intestinal tumor microenvironment and is capable of obviously reducing postoperative metastasis of colorectal cancer.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine preparation for improving the intestinal barrier function of tumor patients and regulating body immunity and a preparation method thereof. Background technique [0002] Colorectal cancer is the fifth most common malignant tumor in my country, and the third among gastrointestinal cancers, and its incidence has shown a rising trend in recent years. The latest CONCORD-3 data shows that the five-year survival rate of colon cancer in my country is significantly lower than that of the United States, Canada, Iceland, Norway and other European and American countries, and it is at the middle-low level among Asian countries and regions. At present, the preferred radical treatment method for colon cancer is still surgery, but patients will have recurrence and metastasis in different proportions due to factors such as venous return and anat...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61P35/00A61P1/00A61P37/04A61K35/57
CPCA61K35/57A61K36/076A61K36/185A61K36/284A61K36/344A61K36/481A61K36/896A61K36/90A61K2236/331A61K2236/39A61P1/00A61P35/00A61P37/04A61K2300/00
Inventor 钟薏付淑娟吴婷婷周张杰杨蕴张士强
Owner SHANGHAI TCM INTEGRATED HOSPITAL
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