Malic acid bicarbonate in vitro hemodialysis agent

Abstract

The invention relates to a malic acid bicarbonate in vitro hemodialysis agent, which comprises a component A and a component B, wherein the component A comprises, by weight, 77-95% of sodium chloride,0-4% of potassium chloride, 2-6% of calcium chloride, 1-3% of magnesium chloride, and 2-10% of L-malic acid, the component B comprises, by weight, 60-100% of sodium bicarbonate, and 0-40% of sodium chloride, and during the use, the final Na<+> concentration is 133-145 mmol / L, the final K<+> concentration is 0-4.0 mmol / L, the final Ca<2+> concentration is 1.0-2.0 mmol / L, the final Mg<2+> concentration is 0.3-1.0 mmol / L, the final Cl<-> concentration is 100-130 mmol / L, the final HCO3<-> concentration is 25-45 mmol / L, and the final H2MA concentration is 2-8 mmol / L. According to the present invention, the malic acid bicarbonate in vitro hemodialysis agent can solve the adverse reactions caused by the acetate radical in traditional hemodialysis agent to patients, can adjust the pH value withina suitable range, can protect the heart function, the liver function, the residual renal function and the normal cells of patients, and is suitable for blood purification and dialysis treatment.

Description

technical field [0001] The invention relates to the field of medical blood purification treatment, in particular to a bicarbonate extracorporeal hemodialysis preparation containing L-malic acid. Background technique [0002] The bicarbonate extracorporeal hemodialysis agent commonly used in the medical industry is mainly composed of sodium chloride (NaCl), potassium chloride (KCl), calcium chloride (CaCl) 2 ), magnesium chloride (MgCl 2 ), acetic acid (HAc), sodium bicarbonate (NaHCO 3 ) or sodium chloride (NaCl). Since it also contains HCO 3 - with Ca 2+ and Mg 2+ Plasma, when the pH value is not good, it is easy to form calcium and magnesium salt precipitation. In order to prevent precipitation, the traditional formula is to add 3-8mmol / L acetic acid, acetate (Ac - ) becomes HCO after being metabolized by the human liver 3 - , It usually takes 3-5 hours to complete, during which some patients have symptoms such as headache, dizziness, nausea, vomiting, convuls...

AI Technical Summary

Problems solved by technology

Since it also contains HCO 3 - with Ca 2+ and Mg 2+ Plasma, when the pH value is not good, it is easy to form calcium and magnesium salt precipitation. In order to prevent precipitation, the traditional formula is to add 3-8mmol / L acetic acid, acetate (Ac - ) becomes HCO after being metabolized by the human liver 3 - , It usually takes 3-5 hours to complete, during which some patients have symptoms such as headache, dizziness, nausea, vomiting, convulsions, hypotension, that is, "acetic acid intolerance". At the same time, acetate and its intermediate metabolites also It may lead to chronic metabolic acidosis, hyperphosphatemia after dialysis, peritoneal fibrosis, and promote the production of inflammatory factors, etc.