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Magnetic nano-fiber drug carrier and preparation method thereof

A magnetic nano-fiber technology, applied in the field of medical materials, can solve the problems of small drug loading, poor loading stability, and unsatisfactory targeted delivery and drug delivery, and achieve stable drug loading, large drug loading, and Realize the effect of drug orientation and targeted drug delivery

Inactive Publication Date: 2018-12-25
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] It can be seen that the nano-drug carriers used for targeted drug delivery in the prior art have problems such as small drug loading, poor loading stability, and unsatisfactory targeted drug delivery, which makes the development and further application of nano-drug carriers restricted

Method used

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  • Magnetic nano-fiber drug carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] a. Disperse keratin in N,N-dimethylformamide, and obtain hollow nano-keratin fibers by electrospinning;

[0031] b, the hollow nano-keratin fiber that step a makes is immersed in FeCl 3 ·6H 2 O, FeCl 2 4H 2 O, in the aqueous solution of organosilane, obtain fiber dispersion liquid;

[0032] c. Apply a vacuum to the dispersion liquid in step b, so that the iron salt enters the pores of the hollow nano-keratin, then add hydrogen peroxide, and add dropwise an aqueous sodium hydroxide solution, so that the iron salt forms a colloid in the hollow nano-keratin;

[0033] d, filter, wash with deionized water until the pH is 7, dry in vacuum, and form silica / Fe in the pores of hollow nanokeratin fibers 3 o 4 Gel network to prepare magnetic nanofiber drug carrier.

[0034] In step b, the organosilane is tetramethylsilane;

[0035] In step a, 7 parts by weight of keratin, 93 parts by weight of N,N-dimethylformamide; in step b, 25 parts by weight of hollow nano-keratin fiber...

Embodiment 2

[0038] a. Disperse keratin in N,N-dimethylformamide, and obtain hollow nano-keratin fibers by electrospinning;

[0039] b, the hollow nano-keratin fiber that step a makes is immersed in FeCl 3 ·6H 2 O, FeCl 2 4H 2 O, in the aqueous solution of organosilane, obtain fiber dispersion liquid;

[0040]c. Apply a vacuum to the dispersion liquid in step b, so that the iron salt enters the pores of the hollow nano-keratin, then add hydrogen peroxide, and add dropwise an aqueous sodium hydroxide solution, so that the iron salt forms a colloid in the hollow nano-keratin;

[0041] d, filter, wash with deionized water until the pH is 7, dry in vacuum, and form silica / Fe in the pores of hollow nanokeratin fibers 3 o 4 Gel network to prepare magnetic nanofiber drug carrier.

[0042] In step b, organosilane is methyl silicone oil;

[0043] In step a, 5 parts by weight of keratin, 95 parts by weight of N,N-dimethylformamide; in step b, 20 parts by weight of hollow nano-keratin fibers, ...

Embodiment 3

[0046] a. Disperse keratin in N,N-dimethylformamide, and obtain hollow nano-keratin fibers by electrospinning;

[0047] b, the hollow nano-keratin fiber that step a makes is immersed in FeCl 3 ·6H 2 O, FeCl 2 4H 2 O, in the aqueous solution of organosilane, obtain fiber dispersion liquid;

[0048] c. Apply a vacuum to the dispersion liquid in step b, so that the iron salt enters the pores of the hollow nano-keratin, then add hydrogen peroxide, and add dropwise an aqueous sodium hydroxide solution, so that the iron salt forms a colloid in the hollow nano-keratin;

[0049] d, filter, wash with deionized water until the pH is 7, dry in vacuum, and form silica / Fe in the pores of hollow nanokeratin fibers 3 o 4 Gel network to prepare magnetic nanofiber drug carrier.

[0050] In step b, the organosilane is vinylsilane;

[0051] In step a, 8 parts by weight of keratin, 92 parts by weight of N,N-dimethylformamide; in step b, 30 parts by weight of hollow nano-keratin fibers, 92 ...

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Abstract

The invention discloses a magnetic nano-fiber drug carrier and a preparation method thereof. The nano-fiber drug carrier is prepared by the following steps: a, mixing keratin and N,N-dimethylformamideand electrostatic-spinning, to obtain hollow nano keratin fibers; b, immerging in water solution of FeCl3.6H2O, FeCl2.4H2O, and organosilane, to obtain fiber dispersion liquid; c, after vacuumizing the liquid, adding hydrogen peroxide and sodium hydroxide water solution, and forming a colloid; and d, filtering, washing, and drying, to obtain the magnetic nano-fiber drug carrier. Through forming asilicon dioxide / Fe3O4 gel network in pore channels of the hollow nano keratin fibers, the magnetic nano-fiber drug carrier has the stable drug loading performance, and is large in drug loading capacity. The prepared nano-fiber drug carrier has a magnetic feature, and is capable of effectively realizing drug orientation and targeted administration.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to the preparation of drug carriers, in particular to a magnetic nanofiber drug carrier and a preparation method. Background technique [0002] In general administration, due to metabolism and degradation, the concentration of ordinary drugs acting on the lesion is too small, and the solubility of the drug in the water phase is low during injection administration, which affects the effect of the drug on the target site. The way to solve this kind of problem is to develop a suitable drug carrier, so that the function of the drug no longer depends only on the properties of the drug itself, but through the carrier to change the distribution of the drug in the body and deliver the drug to the target organ. [0003] At present, nanoparticles are widely concerned due to their unique advantages. Nanoparticles can be targeted through surface modification or the use of special materials, whi...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/02A61K47/04A61K47/42A61K41/00D06M11/49D06M11/79D06M101/12
CPCD06M11/49A61K9/0009A61K9/70A61K41/00A61K47/02A61K47/42D06M11/79D06M2101/12
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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