Method for detecting nicotine release behavior of snus, and special test instrument thereof

Abstract

The invention belongs to the technical field of smokeless tobacco product test, and specifically relates to a method for detecting a nicotine release behavior of snus, and a special test instrument thereof. Structural transformation is performed on an existing medicine dissolution rate instrument according to the consumption characteristics of bagged snus for adapting to snus test, a in vitro detection method capable of simulating the release behavior of the nicotine of the snus in the oral cavity is provided, and a in vitro simulation test is performed on the nicotine release behavior of thebagged snus in combination with the optical fiber conduction technology, the ultraviolet spectrum analysis technology and the computer data processing technology. The maximum advantages of the methodare that in vitro continuous analysis, real-time analysis and online analysis of the nicotine release behavior of the snus is realized, the repeatability is good, the degree of automation is high, andimportant technical support and scientific evidence are provided for the product design, quality control, risk assessment and policy development of the snus products.

Description

technical field [0001] The invention relates to the technical field of in vitro detection of component release behavior of smokeless tobacco products, in particular to a detection method for nicotine release behavior of buccal cigarettes and a special test instrument bag thereof, which can be used for nicotine components in buccal smokeless tobacco products In vitro continuous on-line real-time qualitative and quantitative detection of release, that is, the release degree (%) and release rate (μg·s) of nicotine components in pouched mouth smokeless tobacco products -1 ) for instant online detection. Background technique [0002] Pouched snus is the processed tobacco wet powder packaged in a moisture-permeable pouch. When consumed, it is placed between the upper lip and gums of the mouth without chewing. The tobacco components are released into the mouth after being dissolved in saliva and absorbed through the oral mucosa. . In recent years, as the world's tobacco control p...

AI Technical Summary

Problems solved by technology

Although this method can achieve the purpose of detecting nicotine release, the supporting liquid film is unstable, and the measurement results fluctuate greatly.

In 2011, Zhang Jie et al. developed a set of in vitro release device capable of simulating the release of nicotine in snus in the oral cavity, and used this device to analyze the release of nicotine and free nicotine in snus. This device is the first set in China The in vitro nicotine release experimental device for oral nicotine can simulate the release behavior and distinguish the difference in nicotine release between different samples, but it is a laboratory equipment with cumbersome operation and is not easy to popularize and apply

[0005] The drug dissolution tester is commonly used testing equipment in the field of pharmaceuticals. It is a special instrument for testing the dissolution data of preparations such as tablets, but it has not been found to be used in other fields, especially the tobacco field.

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