Colchicine coating eluting stent and preparation method thereof

A technology of colchicine and stent-eluting, applied in the field of medical devices, can solve the problems of inability to effectively improve the inflammatory response at the vascular injury site, no anti-inflammatory effect, etc., to prevent excessive proliferation of vascular smooth muscle cells, good biocompatibility, Unleash an even, controllable effect

Inactive Publication Date: 2018-12-07
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most drugs are selected to inhibit the proliferation and migration of vascular smooth muscle cells, such as paclitaxel and rapamycin, etc. However, these drugs have no anti-inflammatory effect and cannot effectively improve the inflammatory response at the vascular injury

Method used

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  • Colchicine coating eluting stent and preparation method thereof
  • Colchicine coating eluting stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The colchicine drug-eluting stent of this embodiment includes a stent, a polymer coating coated on the stent, and colchicine loaded on the polymer coating.

[0023] Colchicine is encapsulated in polymer microspheres to achieve the purpose of stable and sustained drug release.

[0024] The polymer microspheres wrapped with colchicine particles have a particle size of 0.01-2 microns.

[0025] The weight ratio of colchicine to polymer coating is 0.5.

[0026] The drug content per square millimeter of the stent surface is 0.1 micrograms.

[0027] Base materials for stents include stainless steel, cobalt alloys, magnesium alloys, and other biocompatible materials.

[0028] The polymer is selected from degradable polymers.

[0029] The degradable polymer is selected from the group consisting of cellulose, polysaccharides, chitin, chitosan or derivatives thereof, polyhydroxyalkyl alcohol esters, poly-beta malates, polyalpha-hydroxyesters, polycaprolactones, Polycyanoacryla...

Embodiment 2

[0039] The colchicine drug-eluting stent of this embodiment includes a stent, a polymer coating coated on the stent, and colchicine loaded on the polymer coating.

[0040] Colchicine is encapsulated in polymer microspheres to achieve the purpose of stable and sustained drug release.

[0041] The particle size of the polymer microspheres wrapped with colchicine particles is 2-10 microns.

[0042] The weight ratio of colchicine to polymer coating was 1.25.

[0043] The drug content per square millimeter of the stent surface is 10 micrograms.

[0044] The base material of the stent includes stainless steel, cobalt alloy, magnesium alloy and other materials with good biocompatibility;

[0045] The polymer is selected from degradable polymers.

[0046] The degradable polymer is selected from the group consisting of cellulose, polysaccharides, chitin, chitosan or derivatives thereof, polyhydroxyalkyl alcohol esters, poly-beta malates, polyalpha-hydroxyesters, polycaprolactones, ...

Embodiment 3

[0056] The colchicine drug-eluting stent of this embodiment includes a stent, a polymer coating coated on the stent, and colchicine loaded on the polymer coating.

[0057] Colchicine is encapsulated in polymer microspheres to achieve the purpose of stable and sustained drug release.

[0058] The particle size of the polymer microspheres wrapped with colchicine particles is 10-50 microns.

[0059] The weight ratio of colchicine to polymer coating is 2.

[0060] The drug content per square millimeter of the stent surface is 20 micrograms.

[0061] The base material of the stent includes stainless steel, cobalt alloy, magnesium alloy and other materials with good biocompatibility;

[0062]The polymer is selected from degradable polymers.

[0063] The degradable polymer is selected from the group consisting of cellulose, polysaccharides, chitin, chitosan or derivatives thereof, polyhydroxyalkyl alcohol esters, poly-beta malates, polyalpha-hydroxyesters, polycaprolactones, Poly...

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Abstract

The invention provides a colchicine coating eluting stent and a preparation method thereof. The colchicine coating eluting stent is characterized by comprising a stent, a polymer coating and colchicine, wherein the polymer coating is coated on the stent; the colchicine is loaded in the polymer coating; the colchicine in the coating is wrapped in the polymer coating in a form of microsphere. The colchicine coating eluting stent provided by the invention has excellent biocompatibility; colchicine release is uniform and controllable; the inflammatory response caused by the stent implanted into alocal part can be obviously restrained; the excessive multiplication of smooth muscle cells of blood vessels and in-stent restenosis can be prevented; the colchicine coating eluting stent is suitablefor clinical application.

Description

technical field [0001] The invention relates to a colchicine-coated elution stent, and also relates to a method for preparing the colchicine-coated elution stent, which belongs to the field of medical devices. Background technique [0002] One of the main complications after coronary stent implantation is in-stent restenosis. Vascular injury and local inflammatory response after stenting cause the proliferation and migration of vascular smooth muscle cells, resulting in vascular intimal hyperplasia and restenosis. At present, most drugs are selected to inhibit the proliferation and migration of vascular smooth muscle cells, such as paclitaxel and rapamycin, etc. However, these drugs have no anti-inflammatory effect and cannot effectively improve the inflammatory response at the vascular injury. Contents of the invention [0003] The object of the present invention is to provide a colchicine-coated eluting stent and a preparation method thereof, so as to solve the above pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14
CPCA61L31/10A61L31/148A61L31/16A61L2300/204A61L2300/416A61L2300/604A61L2300/606
Inventor 沈成兴陈昱金贤
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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