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A Mechanical Perfusion System for Preservation of Isolated Hearts

A heart and mechanical technology, applied in the field of medical devices, can solve the problems of increasing the risk of rejection and infection, limiting the scope of material collection, and not being able to solve the problems of heart and myocardial injury well, so as to prevent ischemia-reperfusion injury, Prolonging the storage time in vitro and solving the effect of insufficient source of heart donors

Active Publication Date: 2019-08-02
嘉兴莱普晟医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned method and perfusion system still need to use blood-containing perfusate for perfusion, because the blood needs to come from a donor, which also limits the scope of sampling
At the same time, the use of blood-containing perfusate increases the risk of rejection and the risk of infection
Moreover, the above-mentioned organ care system cannot well solve the myocardial injury caused by ischemia-reperfusion during the preservation process of the heart.

Method used

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  • A Mechanical Perfusion System for Preservation of Isolated Hearts
  • A Mechanical Perfusion System for Preservation of Isolated Hearts
  • A Mechanical Perfusion System for Preservation of Isolated Hearts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 The composition and connection method of the mechanical perfusion system for heart preservation

[0032] Such as figure 1 As shown, the central processing unit module 1 is connected to the peristaltic pump 7, and the output power of the peristaltic pump is controlled by the control module 20. Further, the peristaltic pump 7 is connected to the cardiac perfusate storage 6, and the cardiac perfusate storage 6 is connected to the cardiac storage via the input conduit 14. The heart storage device 8 is connected to the heart storage device 8, and an opening is provided in the heart storage device 8, and the input catheter 14 can enter the inside of the heart storage device and be connected with the heart preserved in vitro. The peristaltic pump 7 controls the perfusion pressure and flow rate of the perfusate through the change of the output power. The inner wall of the cardiac perfusate reservoir is provided with a cold and heat regulating tube, and the cold and...

Embodiment 2

[0033] Example 2 Procurement and perfusion of donor heart

[0034] 1 experimental animal

[0035] 6-10 male Chinese miniature pigs, weighing 30±3Kg. All experimental animals were treated humanely and complied with the "Guidelines for the Management and Use of Experimental Animals" promulgated by the National Institutes of Health of the United States, and the experimental protocol was approved by the relevant experimental animal ethics committee.

[0036] 2. Method

[0037] (1) Experimental animals were fasted for 8 hours before operation. Anesthesia was induced by intramuscular injection of sodium pentobarbital, and body weight was weighed and recorded. The limbs were immobilized, and the right marginal ear vein access was established. Open the upper and lower jaws to expose the throat, use a laryngoscope to provoke the epipharynx, insert a tracheal tube, and connect a ventilator for assisted breathing. The tidal volume is maintained at 15ml / kg, the respiratory rate is mai...

Embodiment 3

[0043] Example 3 Effect of Itoside on Mechanical Perfusion Preserved Heart in Vitro

[0044] Itoside can scavenge free radicals, inhibit lipid peroxidation, and can prevent and repair damage to cells caused by hypoxia, ischemia or reperfusion. In order to explore the effect of iatonin on mechanically perfused isolated hearts, two different cardiac perfusates were designed in this example, and the specific components are as described in Table 1:

[0045] Table 1 Composition of perfusate A and perfusate B (1L)

[0046]

[0047]

[0048] 1. Perfusion method

[0049] 6 male Chinese miniature pigs, weighing 30±3Kg. Randomly divided into two groups, group A and group B, with 3 rats in each group. Group A was perfused with perfusate A, and group B was perfused with perfusate B. For the acquisition and perfusion of the donor heart, refer to Example 2. The donor heart was mechanically perfused for 8 hours in vitro.

[0050] 2. Detection method of heart state

[0051] 2.1 Det...

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Abstract

The present invention provides a mechanical perfusion system for isolated heart preservation. The mechanical perfusion system comprises a central processor module, a power module, a heart storage module, a liquid circulation module and a monitoring module, wherein the liquid circulation module comprises a heart perfusion liquid storage device, and a heart perfusion liquid is stored in the heart perfusion liquid storage device, and contains itoside, an artificial blood, alpha-galactosidase and alpha-N-acetylgalactosidase. The mechanical perfusion system of the present invention can greatly expand the application range of heart cardiac donors, and can well solve the problem that the heart donor sources are insufficient and the isolated heart cannot be stored for a long time.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a mechanical perfusion system for ex vivo heart preservation. Background technique [0002] In the 1960s, South African doctor Christian Barnard (Barnard) successfully performed the first human heart transplant in Cape Town. Heart transplantation is a very effective surgical treatment for uncorrectable heart deformities and end-stage heart disease. With the advancement of surgical techniques, the improvement of myocardial protection methods and the use of new anti-rejection immunosuppressants, heart transplantation has become an effective means of treating end-stage heart disease. With the wide application of heart transplantation technology, the protection of the donor heart is gradually exposed, and the preservation quality of the donor heart directly affects the survival rate of patients after heart transplantation. [0003] At present, in the clinical pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
CPCA01N1/0247
Inventor 李建辉杨子江郑俊
Owner 嘉兴莱普晟医疗科技有限公司
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