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A kind of preparation method of zinc-containing antibacterial gel

A kind of technology of gel and zinc compound, applied in the field of preparation of zinc-containing antibacterial gel

Active Publication Date: 2021-09-14
XIAN HUIPU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The antibacterial gel made of zinc as a single factor has no application in the field of gynecological sterilization and anti-inflammation and dermatology.

Method used

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  • A kind of preparation method of zinc-containing antibacterial gel
  • A kind of preparation method of zinc-containing antibacterial gel
  • A kind of preparation method of zinc-containing antibacterial gel

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preparation example Construction

[0021] Zinc is a kind of inorganic antibacterial element, because its security is good, bactericidal spectrum, photothermal stability are good etc. many advantages, the gel that the present invention develops is the antibacterial gel of main component with zinc oxide, (zinc oxide is antibacterial to Both Gram-negative and Gram-positive bacteria have strong antibacterial activity). A preparation method for zinc-containing antibacterial gel, comprising the following steps:

[0022] Step 1: select a zinc-containing compound and white carbon black in a certain weight ratio, mix them uniformly, calcinate at high temperature for 2 hours, and sieve after cooling to obtain Si-Zn powder. Among them, the weight ratio of zinc-containing compounds to white carbon black is controlled at (7-25):10, and zinc-containing compounds include Zn-(CH3COO)2, Zn-(CH3COO)2·2H2O, ZnSO4, ZnSO4·6H2O, ZnSO4· One or any combination of 7H2O, ZnO, ZnCO3ZnCl2, Zn(OH)2 Zn(NO3)2·6H2O to obtain Si-Zn powder wit...

Embodiment 1

[0031] A preparation method of zinc-containing antibacterial gel:

[0032] Step 1, the preparation of Si-Zn powder, weigh 68 grams of Zn(CH3COO)2 2H2O, 32 grams of white carbon black (SiO2), after fully mixing, calcining at a high temperature of 500 ° C for 2 hours, after natural cooling, the powder over 200 mesh / inch 2 Sieve and mix to obtain Si-Zn powder, measure the zinc content (about 35%), and determine the consumption of Si-Zn powder when preparing the gel.

[0033] Step 2, the preparation of zinc-containing antibacterial gel, take carbomer 8.5g, purified water 483g, 15% KOH 8.5g, 50% PEG50g, menthyl lactate 1g, propylene glycol 20g, Si-Zn powder 12g, mix and homogenize treatment to obtain zinc-containing antibacterial gel. The prepared zinc-containing antibacterial gel contains 0.62% of zinc, 1.45% of carbomer, 0.17% of menthyl lactate, 3.4% of propylene glycol and 4.3% of PEG. Adding PEG can also enhance the fineness and stability of the colloid.

Embodiment 2

[0035] A preparation method of zinc-containing antibacterial gel:

[0036] Step 1, the preparation of Si-Zn powder, weigh zinc oxide (ZnO) 250g, white carbon black (SiO 2 ) 320g, after fully mixing, calcined at high temperature 500°C for 2 hours, after natural cooling, the powder is over 200 mesh / inch 2 Sieve and mix to obtain Si-Zn powder, and determine the zinc content (about 36%).

[0037] Step 2, the preparation of zinc-containing antibacterial gel, take carbomer 1.45g, purified water 74.2g, 15% KOH 1.4g, Si-Zn powder 2.9g, menthyl lactate 0.1g, propylene glycol 5g, glycerol 15g, Homogeneous treatment after mixing to obtain zinc-containing antibacterial gel. Adding glycerol can also improve colloid fusion performance.

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Abstract

The invention discloses a preparation method of zinc-containing antibacterial gel, which comprises the following steps: step 1, selecting a zinc-containing compound and white carbon black in a certain weight ratio, mixing them evenly, calcining at high temperature for 2 hours, and sieving after cooling to obtain Si ‑Zn powder; step 2, mix carbomer, purified water, KOH, menthyl lactate, propylene glycol, Si‑Zn powder in proportion, and obtain zinc-containing antibacterial gel after homogenization. The present invention uses the Si-Zn compound calcined at a high temperature as the zinc-containing antibacterial gel with a single antibacterial factor, and the prepared antibacterial gel has the characteristics of inorganic antibacterial agents: bactericidal spectrum, heat resistance, safety, durability, and no drug resistance, etc. Combining the unique non-toxic, non-migrating, ultraviolet absorption and scattering capabilities of zinc oxide, the antibacterial gel of the present invention has good colloidal stability, no change in antibacterial performance, and thermal and chemical stability after being stored at 54°C and exposed to sunlight for two months. high sex.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of zinc-containing antibacterial gel. Background technique [0002] Zinc, silver, and copper are all inorganic antibacterial agents, which have the advantages of bactericidal spectrum, high efficiency, heat resistance, safety, durability, and no drug resistance. They have been widely valued and used in medical treatment, daily chemicals, coatings, Textile finishing, plastics and other fields. Zinc and its compounds have high thermal and chemical stability, and have the ability to absorb and scatter ultraviolet radiation. About the antibacterial mechanism of zinc and its compound, its saying is a lot, generally agrees at present, has the following several viewpoints: 1. the catalysis of light can produce active oxygen (·O 2 - ,·OH, 1 o 2 ) It can oxidize with most organic matter, thereby killing or inhibiting the growth and reproduct...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K33/30A61K47/32A61P31/02A61P31/04A61P17/00
CPCA61K9/0014A61K9/06A61K33/30A61K47/32A61P15/00A61P17/00A61P31/02A61P31/04
Inventor 吴晓军
Owner XIAN HUIPU BIOTECH CO LTD
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