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Macromolecular polymer hydrogel composite Medpor ocular prosthesis holder and preparation method thereof

A technology of high molecular polymers and prosthetic eye sockets, applied in eye implants, coatings, medical science, etc., can solve problems such as exposure and eye socket infection, reduce eye socket exposure, be easy to store, and have a wide range of raw material sources Effect

Active Publication Date: 2018-11-23
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to overcome the technical problems of insufficient vascularization of the Medpor prosthetic eye socket in the background technology that lead to eye socket infection and exposure, the purpose of the present invention is to provide a polymer hydrogel composite Medpor prosthetic eye socket and its preparation method, which can promote rapid vascularization. change

Method used

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  • Macromolecular polymer hydrogel composite Medpor ocular prosthesis holder and preparation method thereof
  • Macromolecular polymer hydrogel composite Medpor ocular prosthesis holder and preparation method thereof
  • Macromolecular polymer hydrogel composite Medpor ocular prosthesis holder and preparation method thereof

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Embodiment 1

[0048] 1) Treat the inner surface of the porous frame of the Medpor prosthetic eye seat with plasma surface, and set aside. The Medpor prosthetic eye socket porous scaffold in the embodiment is a high-density porous polyethylene prosthetic eye socket commonly used in clinic (Medpor, Porex Surgical Inc, Newnan, GA, USA).

[0049] In this embodiment, the plasma processor DT-1 is used to modify the inner surface of the high-density porous polyethylene eye socket with oxygen plasma in the air, introduce oxygen-containing polar groups, and improve the hydrophilicity of the material. The method is to put the Medpor porous scaffold into a petri dish, put it into a vacuum chamber, place it at a distance of 3cm from the electrode, and use a high-frequency power supply to discharge it for 20 minutes under a working pressure of 20Pa to obtain a Medpor eye socket with a modified inner surface. , and its scanning electron micrograph is shown in figure 2 shown.

[0050] 2) First take 5ml...

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Abstract

The invention discloses a macromolecular polymer hydrogel composite Medpor ocular prosthesis holder and a preparation method thereof. The ocular prosthesis holder is provided with a porous structure with inner pore channel completely penetrating, wherein the porosity is 50 to 85 percent, an inner diameter of the pore channel is 150 to 800 micrometers, and the wall of the pores is modified by adopting hydrogel. The preparation method comprises the following steps: (1) modifying an inner surface of the Medpor ocular prosthesis holder; (2) preparing a macromolecular polymer suspension solution; and (3) under the ngative pressure condition, guiding a macromolecular polymer into the inner surface-modified Medpor ocular prosthesis holder, cross-linking by using a cross-linking agent, thus obtaining the needed hydrogel composite porous ocular prosthesis holder. The ocular prosthesis holder has a bionic extracellular matrix, so that the biological compatibility of the material can be improved,the viscosity and proliferation of the angiogenesis cells can be promoted, the rapid vascularization of the ocular prosthesis holder can be promoted, the complication of the ocular prosthesis holderafter the implanting operation such as exposure and infection of the ocular prosthesis holder can be reduced, and the application value is good.

Description

technical field [0001] The invention relates to a Medpor prosthetic eye seat in medical biomaterials and a preparation method thereof, in particular to a high molecular polymer hydrogel composite Medpor prosthetic eye seat and a preparation method thereof. Background technique [0002] Enucleation is currently the ultimate surgical treatment for absolute glaucoma, severe ocular rupture, and intraocular malignant tumors. Heavy mental and psychological burden. Selecting eye seat implantation to make up for the loss of orbital content and wearing a suitable eye prosthesis is an ideal treatment plan to repair the loss of the eyeball and restore the appearance of the face. [0003] At present, the clinically used eye socket materials mainly include hydroxyapatite (HA), high-density polyethylene (Medpor), methyl methacrylate (PMMA) and aluminum oxide, among which HA eye socket and Medpor eye socket are the most widely used. widely. The HA eye socket is made of natural coral cal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/34A61L27/54A61L27/56A61F2/14C08F8/36C08F8/38C08F110/02
CPCA61F2/14A61L27/16A61L27/34A61L27/54A61L27/56A61L2300/45A61L2430/16C08F8/36C08F8/38C08L23/06C08L89/00C08F110/02
Inventor 王嫦君叶娟金凯叶昕
Owner ZHEJIANG UNIV
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