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Instant matched chitosan freeze-dried powder

A technology of chitin polysaccharide and freeze-dried powder, which is used in freeze-dried transportation, powder transportation, pharmaceutical formulations, etc., can solve the problems of unstable chemical properties, loss of biological characteristics, and inability to store for a long time, so as to prevent plant transfer, Reduce collagen fiber source, prevent and adhesion effect

Inactive Publication Date: 2018-11-06
JIANGSU HAIERZI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it can be prepared and used now, easy to use and has a long storage period, which solves the problem of unstable physical, mechanical and chemical properties of carboxymethyl chitosan aqueous solution, long-term storage solution degradation and loss of its biological characteristics, and solves the problem that it cannot be stored for a long time

Method used

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  • Instant matched chitosan freeze-dried powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The ready-to-mix chitosan freeze-dried powder includes a double-chamber bag; the double-chamber bag is divided into a solid chamber A and a liquid chamber B;

[0030] Each raw material component and its mass fraction in solid state chamber A and liquid state chamber B are:

[0031] Solid state chamber A:

[0032] Carboxymethyl chitosan freeze-dried powder 0.5%;

[0033] Liquid chamber B:

[0034] Sodium chloride 0.9%;

[0035] Adjust pH to 5.0 with phosphate buffer;

[0036] The balance of water for injection.

[0037] The solid chamber A and the liquid chamber B in the double-chamber bag are arranged side by side, and the connection between the solid chamber A and the liquid chamber B is provided with a virtual welding joint; The reinforcement port 2 and the liquid outlet 1, and the liquid addition port 3 communicated with the liquid chamber B.

[0038] The using method of described double chamber bag is as follows:

[0039] Step 1) Add raw material components a...

Embodiment 2

[0042] The ready-to-mix chitosan freeze-dried powder includes a double-chamber bag; the double-chamber bag is divided into a solid chamber A and a liquid chamber B;

[0043] Each raw material component and its mass fraction in solid state chamber A and liquid state chamber B are:

[0044] Solid state chamber A:

[0045] Carboxymethyl chitosan freeze-dried powder 5.0%;

[0046] Liquid chamber B:

[0047] Sodium chloride 0.8%;

[0048] Adjust pH to 6.5 with phosphate buffer;

[0049] The balance of water for injection.

[0050] The solid chamber A and the liquid chamber B in the double-chamber bag are arranged side by side, and the connection between the solid chamber A and the liquid chamber B is provided with a virtual welding joint; The reinforcement port 2 and the liquid outlet 1, and the liquid addition port 3 communicated with the liquid chamber B.

[0051] The using method of described double chamber bag is as follows:

[0052] Step 1) Add raw material components a...

Embodiment 3

[0055] The ready-to-mix chitosan freeze-dried powder is characterized in that: it includes a double-chamber bag; the double-chamber bag is divided into a solid chamber A and a liquid chamber B;

[0056] Each raw material component and its mass fraction in solid state chamber A and liquid state chamber B are:

[0057] Solid state chamber A:

[0058] Carboxymethyl chitosan freeze-dried powder 0.4%;

[0059] Liquid chamber B:

[0060] Glycine 3.5%;

[0061] Adjust pH to 7.0 with phosphate buffer;

[0062] The balance of water for injection.

[0063] The solid chamber A and the liquid chamber B in the double-chamber bag are arranged side by side, and the connection between the solid chamber A and the liquid chamber B is provided with a virtual welding joint; The reinforcement port 2 and the liquid outlet 1, and the liquid addition port 3 communicated with the liquid chamber B.

[0064] The using method of described double chamber bag is as follows:

[0065] Step 1) Add raw ...

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Abstract

The invention discloses instant matched chitosan freeze-dried powder. The instant matched medical biomaterial used for stopping bleeding, preventing adhesion and controlling cancer cell metastasis applied in perioperative period uses carboxymethyl chitosan freeze-dried powder as a main raw material, water for injection as a carrier and sodium chloride or glycine for osmotic pressure regulation asexcipient, and uses phosphate buffer to adjust pH to prepare a balanced salt solution. In the field of tumor surgery, the freeze-dried powder can prevent implantation metastasis caused by tumor cellsscattered in the human body endometrium during tumor surgery. The freeze-dried powder is non-toxic, non-irritant and non-sensitized to human body, and has good biodegradability and good effects of stopping bleeding, resisting microorganism, preventing adhesion and controlling implantation metastasis of cancer cells.

Description

technical field [0001] The invention relates to a ready-to-mix chitosan freeze-dried powder, which is a ready-to-mix medical hemostasis, anti-adhesion, and control cancer cell transfer biological material used in the perioperative period, and belongs to the category of biological drugs or medical device dressings. Background technique [0002] Clinically applied biomaterials for hemostasis, antibacterial, and anti-adhesion throughout the perioperative period of surgery. The main polymer compounds are: carboxymethyl cellulose, sodium hyaluronate, alginate dressing and chitosan biomaterials. But the only positively charged natural polymer among these materials is chitosan. Because bacteria and other pathogenic microorganisms, cancer cells, red blood cells and platelets have a certain amount of negative charge on the surface, it has good clinical effects of hemostasis, anti-inflammatory, antibacterial, control of cancer cell implantation and metastasis, promotion of wound heal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L31/16A61L31/04A61L31/14A61K9/19A61K31/722A61P35/04A61P35/00
CPCA61K9/19A61K31/722A61L26/0023A61L26/0061A61L26/0066A61L31/042A61L31/14A61L31/16A61L2300/232A61L2300/402A61L2300/404A61L2300/412A61L2400/04A61P35/00A61P35/04C08L5/08
Inventor 胡军胡梦
Owner JIANGSU HAIERZI BIOTECH CO LTD
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