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Ulcerative colitis preventing baicalin-baicalein composition and preparation thereof

A technology of baicalin and baicalein, which is applied in the field of traditional Chinese medicine, and can solve problems such as the reports of no synergy between baicalin and baicalein

Active Publication Date: 2018-11-06
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report on the synergistic effect of baicalin and baicalein on the anti-ulcerative colitis

Method used

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  • Ulcerative colitis preventing baicalin-baicalein composition and preparation thereof
  • Ulcerative colitis preventing baicalin-baicalein composition and preparation thereof
  • Ulcerative colitis preventing baicalin-baicalein composition and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Study on the curative effect of baicalin-baicalein composition on ulcerative colitis model mice

[0019] (1) Experimental animals and groups:

[0020] 80 healthy C57BL / 6 male mice, 6-8 weeks old, weighing 20-25g, were provided by the Experimental Animal Center of Jiangsu University, and the qualification certificate number is SYXK (Su) 2013-0036. Raised in the Experimental Animal Center of Jiangsu University, SPF environment, the temperature of the feeding environment was kept at 20-25°C, the relative humidity was controlled at 50%-60%, and the light and dark alternated every day for 12 hours. The mice were randomly divided into the following eight groups: blank control group, model control group, baicalin group, baicalein group, baicalin-baicalein group (mass ratios were 1:1, 2:1, 4:1, 8:1, respectively). ), 10 per group.

[0021] (2) Experimental plan:

[0022] The mice in the blank control group drank distilled water freely, and the mice in the other gr...

experiment example 2

[0042] Experimental example 2: Preparation of baicalin-baicalein composition tablet

[0043] Weigh 10g of baicalin and 1g of baicalein, add 400g of lactose and starch slurry in an appropriate amount, mix evenly, granulate, sieve and granulate, granulate after drying, add 2g of magnesium stearate, mix evenly, and press into tablets to obtain baicalin- Baicalein composition tablet.

Embodiment 3

[0044] Embodiment 3: the preparation of baicalin-baicalein composition capsule

[0045] Weigh 8g baicalin and 2g baicalein, add 100g lactose, 1g hydroxymethyl starch sodium, appropriate amount of starch slurry, mix evenly, sieve and granulate, dry and granulate, add 1g magnesium stearate, mix evenly and pack into capsules, namely Obtain the baicalin-baicalein composition capsule.

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PUM

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Abstract

The invention discloses an ulcerative colitis preventing baicalin-baicalein composition and a preparation thereof, and belongs to the technical field of traditional Chinese medicines. The compositioncomprises baicalin and baicalein at a mass ratio of 1-10 to 1. According to the invention, a dextran sulphate sodium salt induced ulcerative colitis mice model is adopted, the effect of baicalin-baicalein composition on model mouse is investigated on the aspects of states, pathomorphology and biochemical indicators; experimental results show that compared to baicalin or baicalein used alone, the composition has the good synergistic effect, has the better preventive and therapeutic effect on ulcerative colitis, and can significantly improve symptoms, relieve inflammatory reactions, and promotecolonic mucosal repairing.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a baicalin-baicalein composition for resisting ulcerative colitis and a preparation thereof, that is, a medicine for treating ulcerative colitis by combining baicalin and its aglycone baicalein. Background technique [0002] Ulcerative colitis is a non-specific inflammatory lesion involving the large intestine mucosa and its sublayer whose etiology is not yet fully clarified. The main clinical manifestations are abdominal pain, diarrhea, mucus, pus and blood in the stool, and tenesmus. Its clinical course is long, easy to relapse, and has the risk of potential canceration, seriously affecting people's quality of life, and has been listed by the World Health Organization as one of the modern intractable diseases. At present, there is no radical cure and drugs in Western medicine treatment. Salicylic acid preparations, steroid hormones and immunosuppressants are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61P1/00
CPCA61K31/352A61K31/7048A61P1/00A61K2300/00
Inventor 万瑾毅万靖萱冯颖淑孙竞
Owner JIANGSU UNIV
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