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Non-invasive near-infrared optically-controlled nano-material for repairing damaged nerves

A fluorescent nanomaterial and near-infrared light technology, which is applied in the field of non-invasive near-infrared light-controlled nanomaterials, can solve problems such as not being widely used, and achieve the advantages of avoiding side reactions, improving flexibility, and improving tissue penetration. Effect

Active Publication Date: 2018-10-23
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current UCNPs are mostly used in medical imaging, biosensing, photothermal therapy, photodynamic therapy and other fields. Using them to target tumor cells has not been widely used in the field of neuroregenerative medicine.

Method used

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  • Non-invasive near-infrared optically-controlled nano-material for repairing damaged nerves
  • Non-invasive near-infrared optically-controlled nano-material for repairing damaged nerves
  • Non-invasive near-infrared optically-controlled nano-material for repairing damaged nerves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1NaYF 4 :Yb 3+ ,Er 3+ Synthesis of nanoparticles

[0039] take Y 2 o 3 and CF 3 Put COOH in a round-bottomed flask with a molar ratio of 1:6, add 50mL of pure water, stir to dissolve and distribute evenly, heat up to 120°C, and condense and reflux for 2 hours from the generation of condensed water. After the reflux, the reaction solution was lowered to room temperature, and the insoluble impurities were filtered out with a Buchner funnel. After collecting and filtering, the clear solution was placed on a heating plate to dry most of the water, and then dried in a 140°C oven to form a powder.

[0040] In addition, according to the above method, using Yb 2 o 3 and Er 2 o 3 Replace Y in the above steps 2 o 3 , to synthesize Yb(CF 3 COO) 3 and Er(CF 3 COO) 3 .

[0041] Take Y(CF 3 COO) 3 (0.695mmol), Yb (CF 3 COO) 3 (0.030mmol), and Er(CF 3 COO) 3 (0.010mmol), (CF 3 COO)Na (4mmol) was placed in a 100mL three-necked flask, and 20mL oleic acid a...

Embodiment 2

[0042] The preparation of embodiment 2Glu-UCNP

[0043] The glutamic acid (Glu) modifier was modified onto the UCNPs prepared in Example 1 by the carboxyl substitution method. Dissolve 60mgGlu in 15mL of deionized water and stir for 30min to disperse evenly. Then at 45°C, 40 mg of UCNP prepared in Example 1 were slowly added dropwise, the solution changed from a clear solution to a milky white suspension, and the stirring was continued for 8 hours. After the reaction was completed, it was lowered to room temperature, and the reaction solution was left to stand for 1 hour, and then separated with a separatory funnel, and the lower layer of the aqueous phase was washed with ethanol and water at 14,800 rpm, and redispersed with pure water after washing three times to obtain glutinous rice Amino acid-modified UCNPs, hereinafter referred to as Glu-UCNP.

Embodiment 3

[0045] Polyglutamic acid-modified UCNPs (pGlu-UCNP) were prepared according to the method in Example 2, except that 60 mg Glu in Example 2 was replaced with 60 mg pGlu.

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PUM

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Abstract

The invention relates to a non-invasive near-infrared optically-controlled nano-material for repairing damaged nerves. The non-invasive near-infrared optically-controlled nano-material converts near-infrared light into visible light and / or ultraviolet light. The non-invasive near-infrared optically-controlled nano-material is an up-converting fluorescent nano-material. The invention discloses newuse of the up-converting fluorescent nano-material. In a repairing process of neurons, electrical stimulation does not need to be applied to the neurons, animals do not need to be surgically implantedwith invasive fibers, and near-infrared light with high tissue penetrability is used for stimulating the up-converting fluorescent nano-material in organisms; the converted up-converting fluorescencecan activate photosensitive ion channel protein on the neuronal cell membrane, stimulate the neuronal cells to produce membrane potential changes and enhance the stimulation of the neural circuits, thus repairing the damaged neurons.

Description

technical field [0001] The invention relates to the field of nerve regenerative medicine, in particular to a non-invasive near-infrared light-controlled nanometer material for repairing damaged nerves. Background technique [0002] Optogenetics technology is a brand-new technology produced after the combination of genetics technology and light control technology. Optogenetics technology transforms recipient cells into relevant genes through genetic engineering, and uses light control methods to select and open recipient cells to achieve optical control of cells. Activate or inhibit specific cells by light to clarify their functions, and manipulate the activities of individual types of nerve cells to regulate the functions of related nerve cells, which can help researchers conduct in vivo studies of specific tissue cells and further analyze these cells under pathological and physiological conditions Changes in the biological functions of neurons, and with the help of it, the...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P25/00C09K11/85C09K11/02
CPCA61K41/00A61P25/00C09K11/025C09K11/7773
Inventor 刘坚刘耀波李晨曦黄振晖严俊吉喆
Owner SUZHOU UNIV
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