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Pharmaceutical composition containing chemical ablating agent and biologically-active glycosides, and application thereof

A technology of biological activity and composition, applied in the field of prevention and treatment of local diseases related diseases in mammals, can solve the problems of low curative effect and the like, and achieve the effects of convenient preparation, low local irritation and low cost

Pending Publication Date: 2018-10-23
CHENGDU KUACHANG SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, absolute ethanol still shows very low efficacy against liver tumors larger than 5 cm in diameter

Method used

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  • Pharmaceutical composition containing chemical ablating agent and biologically-active glycosides, and application thereof
  • Pharmaceutical composition containing chemical ablating agent and biologically-active glycosides, and application thereof
  • Pharmaceutical composition containing chemical ablating agent and biologically-active glycosides, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0190] Embodiment 1: the preparation of composition

[0191] 1. Preparation of liquid preparations

[0192]Using the aforementioned preparation method, the composition of the part of the pharmaceutical composition solution of the present invention prepared in this embodiment is listed in Table 2. The excipients therein include vehicles, and unless otherwise specified, all vehicles contain water for injection. The pharmaceutical composition solutions are all stored for more than 2 hours after preparation and used again.

[0193] Table 2

[0194]

[0195] *: The vehicle is an aqueous solution containing 25% ethanol, 15% PEG300 and 15% propylene glycol.

[0196] Specifically, for example, based on the final 100ml composition solution volume, at room temperature, measure the corresponding chemical ablative agent (such as methylene blue or / and quinine dihydrochloride) and active glycoside dry powder according to the amount shown in Table 2 and The dry powder of other optiona...

Embodiment 2

[0205] Example 2: Synergy Research

[0206] 1. In vitro combined activity research

[0207] In this experiment, a human hepatoma cell line (HepG2) was first selected, and a negative control group (normal saline as the negative control) and a drug group were set up, and the tumor cell inhibitory activity of the drug was determined by CCK8 colorimetry. The test solution is the aqueous solution of the given concentration of the test drug, and the experimental conditions and steps are carried out according to the instructions of the cck-8 kit (Nippon Dojin Chemical). Colorimetric selection of 490nm wavelength on the enzyme-linked immunoassay instrument to measure the light absorption value of each well (A 490 ), record the results, draw the cell growth curve with the time as the abscissa and the absorbance value as the ordinate. The inhibitory rate of the drug to tumor cell growth was calculated according to the formula, and the results of the test are listed in Table 3.

[020...

Embodiment 3

[0219] Embodiment 3: super effective activity research

[0220] Activity is actually a relative concept. Within the scope of the present invention, the term "activity" refers to the property of a substance showing a certain therapeutic effect, the term "effective activity" refers to the property of a substance having a therapeutic effect equivalent to existing clinical drugs, and the term "super-effective activity" "Refers to the property that a substance has significantly higher therapeutic effects compared with existing clinical drugs. Taking existing clinical anti-tumor chemotherapeutic drugs (such as 5-fluorouracil) as an example, their tumor-inhibiting rate in the tumor-bearing nude mouse test is 45-75%. This is the curative effect of existing clinical drugs. Hyperpotent activity requires significantly higher therapeutic effects, eg, >75% tumor inhibition in tumor-bearing nude mice.

[0221] Within the scope of the present invention, the terms "activity condition", "ef...

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Abstract

The invention relates to a pharmaceutical composition containing a chemical ablating agent and biologically-active glycosides, and application of the pharmaceutical composition to preparation of drugsused for preventing and treating diseases related to local lesions of mammals.

Description

technical field [0001] The present invention relates to a pharmaceutical composition comprising a chemical ablative agent and an active glycoside, the use of the composition in the preparation of medicines for preventing and treating diseases related to local lesions in mammals, and the method of administering the composition in situ on local lesions A method for preventing and treating local lesion-related diseases in mammals. Background technique [0002] For the treatment of diseases related to local lesions in mammals, especially intractable diseases, such as malignant tumors, intractable inflammation, intractable microbial infections, intractable skin diseases, etc., still mainly rely on such as surgery, chemotherapy and radiotherapy. [0003] Classical chemotherapy is usually carried out by delivering specific and effective chemotherapies against the local lesion pathogen. Classical chemotherapy drugs (such as cytotoxic drugs) are mainly transported to the lesion site...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5415A61K31/49A61K31/616A61K31/60A61K31/7034A61K36/258A61K31/675A61K31/7048A61K33/26A61K33/34A61K31/737A61K31/519A61K33/08A61K33/44A61K45/06A61P35/00
CPCA61K45/06A61K31/49A61K31/519A61K31/5415A61K31/60A61K31/616A61K31/675A61K31/7034A61K31/7048A61K31/737A61K33/08A61K33/26A61K33/34A61K33/44A61K36/258A61K2300/00
Inventor 邹方霖卢星邹礼常王建霞王艺羲
Owner CHENGDU KUACHANG SCI & TECH CO LTD
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