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Multifunctional nano-carrier for tumor photo-thermal synergistic treatment and ultrasound imaging and preparation method thereof

A nanocarrier and ultrasonic imaging technology, applied in the field of nanomaterials, can solve problems such as inflammation, tumor metastasis, and inability to completely eradicate tumor tissue, and achieve the effects of reducing injury, being beneficial to clinical use, and improving utilization.

Active Publication Date: 2018-10-19
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Current studies have found that single use of photothermal therapy can lead to heat resistance in cells, and if the laser power is increased or repeated irradiation will lead to risks such as inflammation and tumor metastasis
And the single use of photothermal therapy cannot completely eradicate the deep tumor tissue, so it is necessary to combine photothermal therapy with other treatment methods

Method used

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  • Multifunctional nano-carrier for tumor photo-thermal synergistic treatment and ultrasound imaging and preparation method thereof
  • Multifunctional nano-carrier for tumor photo-thermal synergistic treatment and ultrasound imaging and preparation method thereof
  • Multifunctional nano-carrier for tumor photo-thermal synergistic treatment and ultrasound imaging and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] This embodiment prepares blank nanocarriers as follows:

[0044] (1) first prepare soluble polypyrrole:

[0045] Weigh 6.6684g of sodium bis(2-ethylhexyl)sulfosuccinate (NaDEHS) into 90mL of deionized water, place in an ice-water bath and stir to dissolve. After it was completely dissolved, 2.769 mL of pyrrole monomer was added to the system, and after stirring for 5 minutes, 10 mL of ammonium persulfate solution (containing 2.282 g of ammonium persulfate) was added to it, and the whole system was reacted in an ice-water bath for 20 h. After the reaction finishes, centrifugation obtains soluble polypyrrole [(Py) 3 + (DEHS) - ] x ;

[0046] (2) Weigh 100 mg of soluble polypyrrole and dissolve in 4 mL of dichloromethane solution, and stir at room temperature until uniformly mixed;

[0047] (3) Weigh 1.2g of polyvinylpyrrolidone (PVP) and dissolve it in 20mL of deionized water as a surfactant solution, and add the solution obtained in step (2) into the PVP solution t...

Embodiment 2

[0051] In this embodiment, nanocarriers loaded with phase change materials are prepared as follows:

[0052] (1) prepare soluble polypyrrole by the method same as embodiment 1;

[0053] (2) Weigh 100mg of soluble polypyrrole and 50mg of menthol and dissolve in 4mL of dichloromethane solution, stir at room temperature until uniformly mixed;

[0054] (3) Weigh 1.2g of polyvinylpyrrolidone (PVP) and dissolve it in 20mL of deionized water as a surfactant solution, and add the solution obtained in step (2) into the PVP solution to obtain a mixed solution;

[0055] (4) Use an ultrasonic cell pulverizer to ultrasonicate the mixed solution intermittently for 3 minutes under the condition of an ice-water bath, so that the oil phase and the water phase are not separated, and obtain nanoparticles with good solubility; then stir at room temperature for 4 hours to volatilize the dichloromethane, obtaining an aqueous dispersion of nanocarriers;

[0056] (5) Centrifuge the aqueous dispersi...

Embodiment 3

[0063] This embodiment prepares drug-loaded nanocarriers as follows:

[0064] (1) prepare soluble polypyrrole by the method same as embodiment 1;

[0065] (2) Weigh 100 mg of soluble polypyrrole and 50 mg of menthol and dissolve in 4 mL of dichloromethane solution, weigh 100 mg of diclofenac and dissolve in 800 μL of dimethyl sulfoxide (DMSO), add it to dichloromethane, and stir at room temperature to mix evenly;

[0066] (3) Weigh 1.2g of polyvinylpyrrolidone (PVP) and dissolve it in 20mL of deionized water as a surfactant solution, and add the above solution into the PVP solution to obtain a mixed solution;

[0067] (4) Use an ultrasonic cell pulverizer to ultrasonicate the mixed solution intermittently for 3 minutes under the condition of an ice-water bath, so that the oil phase and the water phase are not separated, and obtain nanoparticles with good solubility; then stir at room temperature for 4 hours to volatilize the dichloromethane, obtaining an aqueous dispersion o...

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Abstract

The invention discloses a multifunctional nano-carrier for tumor photo-thermal synergistic treatment and ultrasonic imaging and a preparation method thereof. The multifunctional nano-carrier is characterized in that the nano-carrier is of a core-shell structure and takes soluble polypyrrole as a shell structure, and a core is filled with a phase-change material and a small-molecule inhibitor drug.The nano-carrier has the functions of ultrasound contrast diagnosis and photo-thermal synergistic treatment at the same time, the contrast ratio and the definition of an ultrasound image are enhancedby bubbles generated by phase change of the carried phase-change material under the external stimulation, the released drug reduces the level of thermostable protein in cancer cells through a seriesof cascade functions, so that the sensitivity of the cancer cells to heat is remarkably improved, and the effect of photo-thermal treatment is enhanced.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and in particular relates to a multifunctional nanocarrier for tumor photothermal synergistic therapy and ultrasonic imaging and a preparation method. Background technique [0002] According to the statistics of the World Health Organization, the number of new cancer cases is on the rise every year, and cancer has become one of the major diseases that seriously affect human health and threaten human life. In cancer treatment, the main treatment methods include surgery, radiation therapy, and chemotherapy. However, it is found in clinical practice that these methods have certain limitations, making the final treatment effect unsatisfactory. Therefore, it is of great practical significance to develop a new treatment method that is safe, efficient and has few side effects. Studies have found that using the near-infrared light region (650nm-950nm) as the excitation light can not only obtain a ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/22A61K9/51A61K31/196A61K47/34A61P35/00
CPCA61K9/5146A61K31/196A61K41/0052A61K49/225A61P35/00A61K2300/00
Inventor 查正宝周俊红马艳缪昭华
Owner HEFEI UNIV OF TECH
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