Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine for inhibiting proliferation of tumor cells

A technology of tumor cell proliferation and drug application in the field of medicine to achieve good biocompatibility and water solubility, strong controllability, and easy industrialization

Inactive Publication Date: 2018-10-19
GUANGXI UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Faith stone, its main form is arsenic trioxide (As 2 o 3 ), arsenic trioxide has been successfully used in the treatment of leukemia and certain malignant tumors in recent decades, and has the potential to be used as a long-term chemotherapy regimen, but its toxic side effects limit its clinical application to a certain extent, and it is necessary to look for tumors with less toxic side effects Therapeutic drugs, making drugs to kill cancer cells and reduce damage to normal cells is a hot problem today

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine for inhibiting proliferation of tumor cells
  • Medicine for inhibiting proliferation of tumor cells
  • Medicine for inhibiting proliferation of tumor cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] A kind of preparation method of dextran arsenite, is to take dextran and arsenic trioxide (or arsenic) as main raw material, take acetic acid as catalyst, synthesize through high temperature and acid-catalyzed reaction; According to the following operation steps:

[0060] (1) Weigh 10.0g dextran, add 10g water to dissolve, and make 50% dextran T10 aqueous solution;

[0061] (2) Weigh 1.0 g of arsenic trioxide after drying;

[0062] (3) adding the weighed arsenic trioxide into the prepared aqueous solution of dextran, and fully stirring to obtain a mixed slurry of arsenic trioxide and dextran;

[0063] (4) Dropping a small amount of sulfuric acid into the arsenic trioxide dextran mixed slurry to adjust pH=4 to obtain the acidified arsenic trioxide dextran mixed slurry;

[0064] (5) Transfer the acidified arsenic trioxide dextran mixed slurry to the autoclave, heat up to 120°C, and keep the constant temperature reaction for 60 minutes;

[0065] (6) After the reaction is...

Embodiment 2

[0074]A kind of preparation method of dextran arsenite, is to take dextran and arsenic trioxide as main raw material, take hydrochloric acid as catalyst, synthesize through high temperature and acid catalysis reaction; According to the following operation steps:

[0075] (1) Take by weighing 10.0g dextran, add 10g water to dissolve, make 50% dextran aqueous solution;

[0076] (2) Weigh 1.0 g of arsenic trioxide after drying;

[0077] (3) adding the weighed arsenic trioxide into the prepared aqueous solution of dextran, and fully stirring to obtain a mixed slurry of arsenic trioxide and dextran;

[0078] (4) Dropping a small amount of hydrochloric acid into the arsenic trioxide dextran mixed slurry to adjust pH=5 to obtain the acidified arsenic trioxide dextran mixed slurry;

[0079] (5) Transfer the acidified arsenic trioxide dextran mixed slurry to the autoclave, heat up to 150°C, and keep the constant temperature reaction for 30 minutes;

[0080] (6) After the reaction is ...

Embodiment 3

[0088] A kind of preparation method of dextran arsenite, is to take dextran and arsenic trioxide as main raw material, take acetic acid as catalyst, synthesize through high temperature and acid catalysis reaction; According to the following operation steps:

[0089] (1) Take by weighing 10.0g dextran, add 10g water to dissolve, make 50% dextran aqueous solution;

[0090] (2) After weighing and grinding, pass through 1.0g letter stone with 120 mesh sieves;

[0091] (3) Add the weighed Xinshi powder into the prepared aqueous solution of dextran, and fully stir to obtain a mixed slurry of Xinshi dextran;

[0092] (4) Drop a small amount of acetic acid into the Xinshi dextran mixed slurry to adjust pH=3 to obtain the acidified Xinshi dextran mixed slurry;

[0093] (5) Transfer the acidified Xinshi dextran mixed slurry to a high-pressure reactor, heat up to 180°C, and keep the constant temperature reaction for 90 minutes;

[0094] (6) After the reaction is completed, filter and i...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Densityaaaaaaaaaa
Specific rotationaaaaaaaaaa
Densityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a medicine for inhibiting proliferation of tumor cells. A chemical name of the medicine is dextran arsenate. A preparation method comprises the following steps of using dextranand arsenic trioxide or dextran and arsenolite as the main raw materials, using hydrochloric acid, sulfuric acid or acetic acid as a catalyst, treating at high temperature, and catalyzing by acid, soas to synthesize the dextran arsenate. The medicine has the advantages that the sources of the reaction raw materials are wide, the operation technology is simple and is easy to implement, the requirement on equipment is low, the controllability is strong, and the industrialization is easy; a large amount of hydroxyl groups in the original structure of dextran is reserved, and the good biocompatibility, water solubility and medicine release property are realized; the medicine has stronger inhibiting function on cells of lymphoma, colon tumors and liver tumors, the characteristics of strongerin-vitro anti-tumor activity and broad-spectrum anti-tumor effect are shown, the toxic and side effects are reduced, and the broad application value is realized.

Description

technical field [0001] The invention relates to medicine, in particular to a medicine for inhibiting tumor cell proliferation. Background technique [0002] Tumor refers to a new organism formed by abnormal clonal proliferation when local tissue cells lose normal regulation of their growth at the gene level under the action of various tumorigenic factors. Can be divided into benign tumors and malignant tumors. Malignant tumors are currently the most serious diseases that endanger human health, and their morbidity and mortality are increasing significantly. At present, the research and treatment of different types of malignant tumors have progressed to varying degrees, but at this stage, the treatment effect is not good and the prognosis is poor, which is an unsolved problem in the field of human medicine. [0003] The current tumor treatment mainly includes surgical treatment, radiotherapy, chemotherapy and gene therapy, etc. Most of them use radiotherapy and chemotherapy ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/36A61P35/00C08B37/02
Inventor 陈山蓝尉冰农光再李怡静李彭勃
Owner GUANGXI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com