One-step method preparation process of treatment type drug resistant AIDS (acquired immunodeficiency syndrome) autologous plasma virus inactivated vaccine

Abstract

The invention relates to a one-step method preparation process of treatment type drug resistant AIDS (acquired immunodeficiency syndrome) autologous plasma virus inactivated vaccine. Through blood collection, plasma separation and plasma virus inactivation, the vaccine is directly prepared; then, intravenous vaccination is performed; the whole process is completed in a sealed disposable consumable; the pollution risk in the preparation process can be effectively avoided; the vaccine preparation safety is ensured. The preparation process is simple; the cost is low; the inoculation procedure canalso be simplified; the technical requirements of large-dose (600 to 800ml) plasma virus inactivated vaccine inoculation are met. More importantly, the virus strain of the inactivated vaccine is froma patient self; the plasma is also from the patient self; the obvious safety, effectiveness and feasibility are realized. The principle of medical ethics is conformed; the problem of animal model lack of AIDS vaccine development can also be solved. The vaccine is applicable to the continuous treatment of AIDS patients with drug resistance and treatment failure, initial and conventional treatmenton AIDS patients without drug resistance, and emergent blockade treatment on occupational exposure persons.

Description

technical field [0001] The invention relates to a preparation process of plasma virus inactivated vaccine, in particular to a one-step preparation process of therapeutic drug-resistant AIDS autologous plasma virus inactivated vaccine. It is applicable to the prevention and treatment of AIDS, especially the treatment of HIV drug resistance and treatment failure patients. Background technique [0002] AIDS is a new special health problem and public health problem that mankind is facing. It is also a hot spot and problem that the whole world is paying attention to. Since its discovery in 1981, the catastrophic harm to human beings has been known all over the world for 36 years. According to figures released by the World Health Organization, AIDS has caused more than 35 million deaths so far. In 2016, there were still 36.7 million HIV-infected people in the world, about 1.8 million newly-infected people, and 1 million people died of AIDS that year. Although countries have inv...

AI Technical Summary

Problems solved by technology

The main reason is that the existing research and development ideas and conceptual design have not yet found a path and specific method that can overcome the characteristics related to HIV itself, as well as the pathogenic mechanism of HIV and the characteristics of the human body's immune response to HIV

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