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A neuroglioma protein marker and a purpose therefor

A glioma, protein technology, applied in the field of protein markers

Inactive Publication Date: 2018-08-31
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, imaging information does not provide valuable diagnostic clues earlier in the disease

Method used

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  • A neuroglioma protein marker and a purpose therefor
  • A neuroglioma protein marker and a purpose therefor
  • A neuroglioma protein marker and a purpose therefor

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Embodiment 1

[0045] Embodiment 1: Establishment of glioma rat model

[0046] In the present invention, glioma cell C6 was injected into the right caudate nucleus of rats to simulate the pathophysiological state of glioma. The present invention collects the urine of glioma rats in the early stage (2 days, 6 days after operation) and middle and late stage (10 days, 13 days after operation). Using this animal model to simulate glioma has important guiding significance for clinical early diagnosis, treatment and prognosis of glioma.

[0047] 1. Materials and reagents

[0048] 1) Instrument: Rat urine collection tube: purchased from BD Company. Thermo orbitrap fusion lumos mass spectrometer: purchased from Thermo Fisher Scientific; Thermo EASY-Nlc1200 high-performance liquid chromatography: purchased from ThermoFisher Scientific; MillliQ RG ultrapure water system: purchased from Millipore; C18 reversed-phase analytical column (RP column ,0.1×150mm,3μm, ): purchased from Michrom Bioresource...

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Abstract

The invention relates to a neuroglioma protein marker and a purpose therefor. The invention relates to the utilization of human neuroglioma differential protein obtained by a rat model in which the right side caudate nucleus of the rat is injected with neuroglioma cells and mass spectrometry as a latent neuroglioma marker for the purpose of early stage diagnosis, and condition monitoring. The marker includes: a glutamyl amino peptidase, an amino-peptidase N, a glutathione synthetase, neutral and alkaline amino acid transportation protein, calmodulin, a solute carrier household 7 member 13, a gamma-glutamyl transpeptidase 1, an organic anion transportation carrier family, a glutamic acid-cysteine ligase regulation subunit, an EH structural domain protein 1, a cystathionine gamma-lyase, a quinone oxidoreductase and the like. The selection of the more simple, faster, and more noninvasive method for diagnosing the neuroglioma is provided.

Description

technical field [0001] The invention relates to clinical medicine, in particular to human glioma-related protein markers. Specifically, the present invention relates to the use of protein markers related to the diagnosis and disease monitoring of human glioma obtained by using a rat glioma model and mass spectrometry analysis. Background technique [0002] Urine proteomics is of great significance in disease research. Markers are measurable changes associated with physiological and pathophysiological states. Urine is not regulated by homeostasis mechanisms and can reflect various early changes, so it is a good place to look for early biomarkers of diseases (see Youhe G. Can urine be the gold mine for biomarker discovery? Sci China Life Sci 2013; 43) . [0003] While the central nervous system is metabolizing at a high speed, it will metabolize the metabolites produced in the direction of decreasing the steady-state level. Metabolic waste products can be excreted into the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/68G01N33/57407G01N33/57488G01N2800/28G01N2800/56
Inventor 高友鹤倪艳颖张繁霜
Owner BEIJING NORMAL UNIVERSITY
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