Microwave extraction method for cardiovascular traditional Chinese medicine prescription

An extraction method and cardiovascular technology, which is applied in the fields of cardiovascular system diseases, pharmaceutical formulations, solid solvent extraction, etc., can solve the problems of poor thermal stability and achieve the effect of shortening the extraction time

Inactive Publication Date: 2018-08-10
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although commonly used traditional methods such as decoction and reflux extraction can extract active ingredients to varying degrees, they are not suitable for ingredients with poor thermal stability

Method used

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  • Microwave extraction method for cardiovascular traditional Chinese medicine prescription
  • Microwave extraction method for cardiovascular traditional Chinese medicine prescription
  • Microwave extraction method for cardiovascular traditional Chinese medicine prescription

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The present embodiment provides a microwave extraction method of cardiovascular traditional Chinese medicine, comprising the following steps:

[0077] 1) Accurately weigh 40g of coix seed, 12g of orange red, 20g of aconite, and 20g of red ginseng with an electronic analytical balance;

[0078] 2) Put the weighed Chinese herbal medicine into the microwave extractor after cleaning;

[0079] 3) Weigh 800mL of distilled water with an electronic balance, and inject it into the microwave extractor;

[0080] 4) Soak for 30 minutes;

[0081] 5) Set the power of the microwave extractor to 400-1200W, start to extract the compound Chinese medicine, and take a sample every 8 minutes until 40 minutes;

[0082] 6) Cool the extracted samples and put them in the refrigerator for later use.

Embodiment 2

[0084] In this embodiment, by setting up comparative experiments, the influence of microwave power on the concentration of active ingredients in the extract is analyzed. Specifically: under the condition that the soaking time is 30min, the extraction time is 32min, and the number of extractions is 1 time, the power of the microwave extractor in step 5) is respectively set to 400W, 600W, 800W, 1000W, 1200W for extraction. After measuring the concentration of active ingredients in the extract, the effect of microwave power on the concentration of active ingredients in the extract is as follows: figure 1 shown.

[0085] Depend on figure 1 It can be seen that ginsenoside Rg 1 The concentration increases with increasing microwave power. This is because the greater the microwave power and the greater the microwave energy, the faster the liquid in the cell is vaporized into a gaseous state, so that the cell wall and cell membrane are damaged faster and to a greater extent, and the...

Embodiment 3

[0087] In this embodiment, by setting up comparative experiments, the influence of extraction time on the concentration of active ingredients in the extract is analyzed. Specifically: Under the conditions of soaking time of 30 minutes, microwave power of 1200W, and extraction times of 1 time, the extraction was carried out at extraction times of 8 minutes, 16 minutes, 24 minutes, 32 minutes, and 40 minutes, and the active ingredients in the extract were determined after the extraction was completed. concentration, the effect of extraction time on the concentration of active ingredients in the extract is as follows: figure 2 shown.

[0088] The results showed that, on the whole, as the extraction time increased, the ginsenoside Rg in the extract 1 concentration gradually increased. This is because the time of microwave radiation increases, the time for microwave radiation to act on cells increases, the degree of damage to the cell wall increases, and more active ingredients ...

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Abstract

The invention relates to an extraction method of traditional Chinese medicine compound preparations and particularly relates to a microwave extraction method for a cardiovascular traditional Chinese medicine prescription. By utilizing microwaves, liquid water such as cell sap in vegetable cells is rapidly facilitated to change into vapor, so that the pressure in the cells is increased, the cell membranes and cell walls are broken, and the extraction time of the active ingredients can be shortened when the active ingredients are dissolved into the solvent. Compared with the traditional heatingextraction method, the microwave-assisted extraction technology can obviously shorten the extraction time of the active ingredients and has the advantages of being high-efficiency and energy-saving.

Description

technical field [0001] The invention relates to an extraction method of a compound traditional Chinese medicine preparation, in particular to a microwave extraction method of a cardiovascular Chinese medicine prescription. Background technique [0002] In recent years, with the trend of "returning to nature" and the country's strong advocacy of local culture, Chinese medicine has attracted more and more attention. At the same time, traditional Chinese medicine has become a research hotspot for scholars. The extraction of chemical components of traditional Chinese medicine is the premise and key of modern research on traditional Chinese medicine. At present, there are various extraction methods of natural products. Although commonly used traditional methods such as decoction and reflux extraction can extract active ingredients to varying degrees, they are not suitable for ingredients with poor thermal stability. [0003] Microwave is an electromagnetic wave with a waveleng...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P9/00B01D11/02
CPCA61K36/258A61K36/714A61K36/752A61K36/8994A61K2236/331A61P9/00B01D11/02A61K2300/00
Inventor 郑成刘丹彤毛桃嫣
Owner GUANGZHOU UNIVERSITY
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