Glucose-sensitive type full interpenetrating network hydrogel and preparation method thereof
A glucose-sensitive, interpenetrating network technology, applied in the field of glucose-sensitive hydrogel and its preparation, can solve the problems of reducing PBA pKa, low pKa, low reproducibility, etc., and achieves improved response intensity and response rate, and mild reaction conditions. , the preparation method is simple
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[0037] The invention relates to a hydrogel sensitive to glucose under physiological conditions, and a method for preparing a temperature-sensitive hydrogel with mild reaction conditions and simple synthesis route. Glucose-sensitive fully interpenetrating network hydrogels based on PBA were synthesized through the interpenetration of networks formed by acrylamidophenylboronic acid (AAPBA)-based polymers and chitosan (CS). AAPBA, amides and the third monomer undergo free radical polymerization in the CS solution containing the first cross-linking agent, accelerator and initiator, and at the same time CS is cross-linked under the action of the second cross-linking agent. Glucose concentration-responsive hydrogels.
[0038]Among them, amides can be acrylamide (AM) or methacrylamide (MAm); the third monomer can be dimethylacrylamide (DMAA), dimethyl ethyl methacrylate (DMAEMA) or N-isopropyl base acrylamide (NIPAM); the first crosslinking agent is a diene crosslinking agent, such ...
Embodiment 1
[0052] The meaning of the data in brackets in Example 1 is marked in detail, and the meanings in brackets of each substance in other examples are the same as those in Example 1.
[0053] Example 1: Preparation of P(AAPBA-DMAA-AM) / CS-GA fully interpenetrating network hydrogel
[0054] (1) Dissolve 0.2 g of CS with a molecular weight of 300,000 in 10 ml of water to prepare a 2% CS solution.
[0055] (2) Pipette 1ml of CS solution, accurately weigh AAPBA: 0.096g (mole percent: 6%), AM: 0.156g (mole percent: 26%) and DMAA: 0.6ml (mole percent: 68%), crosslinking agent MBA : 4.14mg (0.5% of the mass sum of the three monomers) was placed in the solution, pipetted with a pipette and TEMED: 10ul, magnetically stirred for 10min until the solution was uniform, and at the same time, 0.5ml of freshly prepared APS solution (40mg / ml ) (2.4% of the mass sum of the three monomers), 10ul of GA solution, continued to stir for 20min, took out the magnet, and left it at room temperature for 24h ...
Embodiment 2
[0059] Example 2: Preparation of P(AAPBA-DMAA) / CS-GA fully interpenetrating network hydrogel
[0060] (1) Dissolve 0.2 g of CS with a molecular weight of 300,000 in 10 ml of water to prepare a 2% CS solution.
[0061] (2) Pipette 1ml of CS solution, accurately weigh AAPBA: 0.096g (5%) and DMAA: 1.0ml (95%), cross-linking agent MBA: 0.0106mg (1%) in the solution, pipette Take TEMED: 10ul, magnetically stir for 10min until the solution is uniform, add freshly prepared APS solution 0.2ml (40mg / ml) (0.75%), GA solution 10ul, continue stirring for 20min, take out the magnet, and stand at room temperature for cross-linking reaction .
[0062] (3) The prepared hydrogel was divided into small pieces, placed in distilled water to remove monomers, and the water was changed every 6 hours. After 48 hours, the samples were freeze-dried for subsequent related performance tests.
[0063] (4) Put a small piece of dry sample in PBS buffer solution (pH=7.3) to achieve equilibrium, and then pl...
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