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Climbazole microcapsule and hair care composition comprising surfactant and climbazole

A technology of Climbazole and hair care, applied in the field of Climbazole composition, can solve the problems of no loading of Climbazole, poor release, no examples of using Climbazole, etc.

Active Publication Date: 2018-07-31
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We have now found that this type of particle presents a double problem: low climbazole inclusion due to its capsular structure and poor release of climbazole from the particle
There is no disclosure on how to load the melamine-formaldehyde sachets of Climbazole, and no examples of the use of Climbazole

Method used

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  • Climbazole microcapsule and hair care composition comprising surfactant and climbazole
  • Climbazole microcapsule and hair care composition comprising surfactant and climbazole
  • Climbazole microcapsule and hair care composition comprising surfactant and climbazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] The selection of embodiment 1-solvent

[0145] The manufacturer of AD (climbazole tested) states in their published literature: " AD[…] has good compatibility with fragrance oils and other common hair care ingredients and is soluble in alcohols, glycols, surfactants and certain fragrance oils.”

[0146] A number of fragrance components, fragrance blends, and oils considered safe for use on the scalp were screened for their ability to dissolve climbazole. Since emulsion polymerization also encapsulates solvents, highly efficient solvents are required to achieve high loading of climimazole into microcapsules.

[0147] We found that many of the oils and fragrances tested were not effective at dissolving clomidazole at the rates tested, in particular: ethyl cinnamate, anethole, coconut oil, eucalyptus oil and propylene glycol failed to dissolve clomiprazole at any of the rates tested Bazole.

[0148] On the basis of this screening work, β-ionone (solvent to climbazol...

Embodiment 2- 3

[0149] Embodiment 2-melamine formaldehyde microcapsule synthesis

[0150] A large number of melamine formaldehyde encapsulates were synthesized using the following method, which encapsulated the preferred cimembazole in the oil solution from Example 1. The materials used in the encapsulation are given in Table 1.

[0151] Table 1 - Materials used

[0152]

[0153] In a 300 ml reaction vessel, 19.5 g of formalin (37% by weight formaldehyde in water) were added to 44 g of water. The pH was adjusted to 8.9 using 5% sodium carbonate. 10 g of melamine was added thereto along with 0.64 g of sodium chloride and stirred at room temperature for 10 minutes. The resulting solution was heated to 62°C and stirred until clear. This yielded a prepolymer of 23.2% by weight trimethylolmelamine in water.

[0154] Will 4g AD was pre-dissolved in solvent, in this case β-ionone (20 g) in a 5:1 weight ratio.

[0155] In a second 300ml reaction vessel, 108.9g of water was added and he...

Embodiment 3

[0157] Embodiment 3-inhibition zone test

[0158] Materials used: Model sebum analog consisting of 77% Captex 8000 (tricaprylyl) (Abitec) and 23% squalene (Aldrich)

[0159] Culture preparation

[0160] 1. Prepare an inoculum by adding a platinum loopful of culture from an agar plate subculture of Malassezia furfur to sterile tryptone in a bottle. The culture was stirred for about 1 hour, then allowed to settle for about 20 minutes.

[0161] 2. Carefully remove the supernatant to another sterile bottle and adjust the optical density represented by McFarland Unit to 2.0 (approximately 1.2E06cfu / ml).

[0162] 3. Prepare the inoculum from the original culture preparation by making a 1 / 4 dilution (eg, 2 ml culture to 6 ml tryptone).

[0163] Table 2 - Test Solutions

[0164]

[0165] Perfume 1 is a model perfume composed of equal parts of top fragrance, middle fragrance and tail fragrance, and its composition is: 11.3% by weight of 2-(1,1-dimethylethyl)-cyclohexanol 1-a...

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Abstract

A core shell microcapsule wherein the liquid core of the microcapsule comprises solvent and climbazole dissolved in the solvent in a weight ratio of at most 8:1, preferably at most 5:1, solvent: climbazole. Also a process to manufacture the core shell microcapsule comprising the steps of: a) Dissolving climbazole in solvent to form an oil phase; b) Mixing the oil phase with an oil soluble first component of a shell forming polymerization system; c) Dispersing the mixture from step b in an aqueous phase which either contains, or has added to it, a water soluble second component of a shell forming polymerization system; d) Forming microcapsules by reaction of the first and second components of the polymerization system to encapsulate the climbazole dissolved in the solvent; and e) Optionallyseparating the formed microcapsules from the aqueous phase. Also a hair care composition comprising surfactant and at least 0.1 wt% of a core shell microcapsule comprising a polymer shell and a corecomprising climbazole and solvent wherein the climbazole is dissolved in the solvent in a weight ratio of at most 8:1, preferably at most 5:1 solvent.

Description

technical field [0001] The present invention relates to microcapsules comprising climbazole, a process for the preparation of microcapsules comprising climbazole and anti-dandruff hair care compositions, in particular comprising a surfactant and climbazole as anti-dandruff active Compositions. Background technique [0002] Climbazole is a racemate composed of equimolar amounts of (R)- and (S)-climbazole, and its IUPAC name is (RS)-1-(4-chlorophenoxy)-1- Imidazol-1-yl-3,3-dimethylbutan-2-one, CAS number 38083-17-19. It is a topically applied antifungal agent used to treat fungal skin infections in humans. It can be included in over-the-counter anti-dandruff shampoo preparations and skin treatment compositions to treat dandruff and eczema where fungal infections are the cause. [0003] At a level of 1% by weight inclusion into an anti-dandruff shampoo composition comprising a detersive surfactant, it has been shown that only about 0.05% by weight of the included Climbazole ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q5/00A61K8/35A61K8/73A61K8/81A61K8/87A61K8/11A61K8/49A61K8/92A61K9/00A61K9/51
CPCA61K8/35A61K8/4946A61Q5/006A61K8/922A61K9/0014A61K47/08A61K9/06A61K47/44A61K9/5015A61K2800/412A61K2800/56A61K8/11A61K8/731A61K8/84A61K2800/624A61P17/00A61P31/10
Inventor P·弗古森A·M·古尔斯布拉C·C·琼斯D·R·A·梅亚林G·P·穆尔克林A·P·帕克
Owner UNILEVER IP HLDG BV
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