Wearable mouse brain stimulation ultrasonic transducer

Abstract

The invention relates to a wearable mouse brain stimulation ultrasonic transducer. The wearable mouse brain stimulation ultrasonic transducer comprises a circulator and a piezoelectric array element;a backing block is embedded in the circulator; the piezoelectric array element is connected with the backing block; the piezoelectric array element includes a piezoelectric material layer; one side surface of the piezoelectric material layer has a concave surface, and the shape of the concave surface matches the outer contour shape of a mouse brain skull; an outer electrode is arranged on the concave surface; an inner electrode is arranged on the other side surface of the piezoelectric material layer; an installation hole for installation of an SMA interface is formed in the backing block; theouter electrode is electrically connected to a threaded electrode of the SAM interface; and the inner electrode is connected to a central electrode of the SAM interface. In the technical scheme, thetransducer can achieve focusing by using the concave surface, a large amount of energy is projected to a small area to achieve nerve stimulation; MRI is the highest monitoring method for biological tissue resolution in the prior art, the mouse brain is small, MRI detection can be performed during ultrasonic stimulation so as to achieve a similar real-time detection effect.

Description

technical field [0001] The invention relates to the field of transducers, in particular to a wearable ultrasonic transducer for brain stimulation of mice. Background technique [0002] Neurostimulation methods provide a powerful tool for the study of brain function, and are especially helpful for neurological and psychiatric treatment research. Electrical, optical, magnetic, and acoustic modulation methods have been used for neural stimulation. Deep brain stimulation (DBS) and optogenetics are classic and effective stimulation methods, but these invasive methods have their drawbacks. Transcranial direct electrical stimulation (tDCS) and transcranial magnetic stimulation (TMS) are widely used non-invasive brain stimulation methods, but they cannot achieve high-resolution stimulation in deep brain tissue. Recent studies have shown that ultrasound, as an effective means of non-invasive neurostimulation, can effectively modulate the neural activity of neurons, rodents, monkeys...

AI Technical Summary

Problems solved by technology

[0003] Low frequency (<1MHz) ultrasound is better because it penetrates the skull effectively, but does not provide a smaller focal area

High-frequency ultrasound can provide a smaller focal area, but the attenuation of high-frequency ultrasound is relatively strong, and the penetration depth may be limited. Especially if the skull is not removed, it may not be possible to treat deep brain tissue within a safe power range. achieve neurostimulatory effect

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