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Method for preparing ranitidine hydrochloride capsules

A technology of ranitidine hydrochloride and capsules, which is applied in the field of preparation and production of ranitidine hydrochloride capsules, can solve the problems of short storage time, toxic and side effects of auxiliary materials, weak stability, etc. The intake of excipients, the effect of a wide range of applications

Inactive Publication Date: 2018-07-06
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Ranitidine hydrochloride is extremely deliquescent, and after absorbing moisture, the color becomes darker and the content decreases
Ranitidine hydrochloride preparations that have been on the market include capsules, ordinary tablets, injections, effervescent granules, chewable tablets, effervescent tablets, oral liquids, syrups, etc. Among them, ranitidine hydrochloride capsules often need to be filled At least 4 kinds of auxiliary materials such as agent, lubricant, disintegrant, binder, etc., such as 11 kinds of auxiliary materials such as bismuth potassium citrate, chitosan, and sodium alginate used in CN201010211284.0; CN200910158241.8 first needs Butyl ester plastids were prepared, and 4 kinds of auxiliary materials such as egg yolk lecithin, cholesterol, and sodium glycocholate were added. Studies have shown that the auxiliary materials themselves have toxic and side effects, the incompatibility between the auxiliary materials and the main drug, and the impurities in the auxiliary materials will also affect the drug. safety impact
Due to different excipients, the capsules have the defects of short storage time and weak stability

Method used

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  • Method for preparing ranitidine hydrochloride capsules
  • Method for preparing ranitidine hydrochloride capsules
  • Method for preparing ranitidine hydrochloride capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 5.0g ranitidine hydrochloride and 5.0g tapioca starch, grind them in a mortar respectively, and pass through an 80-mesh sieve to obtain a uniform powder, mix tapioca starch and ranitidine hydrochloride powder, grind for 30min, and after grinding for 10min, Put it in a microwave oven, heat it with 700W microwave for 5min, and microwave it twice to get a uniform medicinal powder, put the medicinal powder into No. 0 hydroxypropyl starch capsules, and fill each capsule with 50mg medicinal powder to prepare 100 capsules.

Embodiment 2

[0018] Weigh 1.0 g of ranitidine hydrochloride and 5.0 g of tapioca starch, grind them in a mortar respectively, and pass through an 80-mesh sieve to obtain a uniform powder, mix tapioca starch and ranitidine hydrochloride powder, and grind for 30 minutes, and after grinding for 10 minutes, Put it in a microwave oven, heat it with 700W microwave for 5min, and microwave it twice to get a uniform medicinal powder, put the medicinal powder into No. 0 hydroxypropyl starch capsules, and fill each capsule with 50mg medicinal powder to prepare 100 capsules.

Embodiment 3

[0020] Take by weighing 1.0g ranitidine hydrochloride, 10.0g tapioca starch and potato starch mixture, put into mortar respectively and grind, cross 80 mesh sieves, obtain uniform powder, mix tapioca starch and ranitidine hydrochloride powder, grind 30min, After grinding for 10 minutes, put it into a microwave oven, heat it with 1200W microwave for 5 minutes, and microwave it twice to obtain a uniform medicinal powder. Put the medicinal powder into No. 0 hydroxypropyl starch capsules, and fill each capsule with 50 mg of medicinal powder to prepare 100 capsules.

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PUM

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Abstract

The invention discloses a method for preparing ranitidine hydrochloride capsules. Each capsule contains 10-20 parts of a bulk drug and 10-100 parts of starch. 10-20 parts by weight of the bulk drug and 10-100 parts by weight of the starch are mixed and ground in a mortar, microwave heating is carried out several times during the mixing and grinding, and capsules are filled with the obtained mixedranitidine hydrochloride drug powder to prepare the ranitidine hydrochloride capsules. The ranitidine hydrochloride capsules only adopt the single-component starch auxiliary material under above technologic conditions, so the ranitidine hydrochloride capsules have a good stability in influence factor experiments prescribed in pharmacopeia.

Description

technical field [0001] The invention relates to a preparation method of capsules, in particular to a preparation and production method of ranitidine hydrochloride capsules. Background technique [0002] Ranitidine hydrochloride is very easy to deliquesce, and after absorbing moisture, the color will become darker and the content will decrease. Ranitidine hydrochloride preparations that have been on the market include capsules, ordinary tablets, injections, effervescent granules, chewable tablets, effervescent tablets, oral liquids, syrups, etc. Among them, ranitidine hydrochloride capsules often need to be filled At least 4 kinds of auxiliary materials such as agent, lubricant, disintegrant, binder, etc., such as 11 kinds of auxiliary materials such as bismuth potassium citrate, chitosan, and sodium alginate used in CN201010211284.0; CN200910158241.8 first needs Butyl ester plastids were prepared, and 4 kinds of auxiliary materials such as egg yolk lecithin, cholesterol, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/341
CPCA61K9/4816A61K9/4833A61K9/4866A61K31/341
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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