A kind of preparation method of dextran/nano gold-silver alloy composite

A technology of dextran and nano-gold, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of high temperature, slow reaction speed, and difficult silver nanoparticles, etc., and reach the particle size Uniformity, good antibacterial effect, simple operation steps

Active Publication Date: 2020-12-29
ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, cyclodextrin, chitosan, cellulose, pullulan, dextran, sodium alginate and their derivatives have been used as reducing agents and stabilizers to synthesize gold nanoparticles greenly in aqueous solution, but using dextran It is not easy to reduce silver nitrate with sugar to prepare silver nanoparticles. For example, the common silver mirror reaction needs to be carried out under alkaline conditions. The reaction speed of direct reduction of silver nitrate by dextran is slow and requires high temperature conditions.

Method used

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  • A kind of preparation method of dextran/nano gold-silver alloy composite
  • A kind of preparation method of dextran/nano gold-silver alloy composite
  • A kind of preparation method of dextran/nano gold-silver alloy composite

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Effect test

Embodiment 1

[0034] A preparation method of dextran / nano gold-silver alloy composite, comprising the following steps:

[0035] (1) Seal and dissolve dextran (2-10 mg / mL) in water, continuously stir and quickly add 0.5-1.0 times the volume of chloroauric acid solution dropwise, then use high-power microwave heating to obtain dextran reduction prepared by rapid reaction Gold nano-seeds with smaller particles; the mass ratio of dextran and chloroauric acid used is 100:1-20:1, the microwave power is above 800W, and the reaction time is within 2 minutes; the amount of dextran used in the reaction is far more than that of gold The amount of ions used is because dextran not only participates in the reaction as a reducing agent, but also acts as a stabilizer by being adsorbed on the surface of nanoparticles. Dextran is preferably dextran with a molecular weight of 7W; microwave heating is mainly due to its The heating is uniform and fast, and nano-seeds with smaller particle size and uniformity ca...

Embodiment 2

[0040] Dextran (8 mg / mL) was sealed and dissolved in 100 mL of water, and chloroauric acid solution (equal volume 0.1 mg / mL) was added dropwise rapidly with continuous stirring, and then heated with high-power microwave (1000W) for two minutes to obtain gold nano-seeds / dextran solution; after the gained gold nano-seed / dextran solution is cooled to room temperature, add silver nitrate solution, the mol ratio of gold-silver ion is 1:1, seal after mixing evenly, heat and stir at 70 ℃ for 20 minutes, The dextran / nano gold-silver alloy composite solution is obtained, and then filtered, centrifuged, dispersed, dialyzed and freeze-dried to obtain polysaccharide gold-silver alloy nanoparticles. The ultraviolet absorption peaks of the synthesized gold-silver alloy nanoparticles in aqueous solution are as follows: figure 1 As shown, there is a single peak, and there is no single absorption peak of gold or silver nanoparticles, indicating that the nano-alloy particles were successfully ...

Embodiment 3

[0042] Dextran (6 mg / mL) was sealed and dissolved in water, and chloroauric acid solution (equal volume 0.1 mg / mL) was added dropwise rapidly with continuous stirring, and then heated with high-power microwave (1000W) for two minutes to obtain gold nano-seeds / glucose polysaccharide solution; after cooling the obtained gold nano seed / dextran solution to room temperature, add silver nitrate solution, the molar ratio of gold and silver ions is 1:5, seal it after mixing evenly, and heat and stir at 70°C for 25 minutes to obtain glucose The polysaccharide / nano gold-silver alloy complex solution was then filtered, centrifuged, dispersed, dialyzed and freeze-dried to obtain the polysaccharide fund-silver nanoparticle alloy. The ultraviolet absorption peaks of the synthesized gold-silver alloy nanoparticles in aqueous solution are as follows: image 3As shown, there is also a single peak, indicating the successful synthesis of nano-alloy particles. The morphology of the alloy particl...

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Abstract

The invention relates to a preparation method of a glucan / nanogold-silver alloy compound. Gold nanoseed / glucan is adopted as seeds to prepare into the glucan / nanogold-silver alloy compound throughsynthesis. According to the preparation method of the glucan / nanogold-silver alloy compound provided by the invention, the gold nano particles are adopted as the seeds and can provide attachment points for the growth of silver nano particles, so that the required reaction temperature is greatly reduced, and the reaction time is reduced; and the synthesized gold-silver alloy compound is uniform inparticle size, so that the antimicrobial activity of nano silver is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of green preparation of nano-alloy materials, and in particular relates to a dextran / nano-gold-silver alloy compound with antibacterial activity and a preparation method thereof. Background technique [0002] In recent years, nano-sized functional nanoparticles and polymer assemblies have remarkable efficacy in the construction of nanomaterials, and have attracted widespread attention. Among them, the antibacterial activity of silver nanoparticles is good, and has a broad spectrum, and has a good inhibitory effect on different bacterial species, and silver nanoparticles are non-antibiotic bactericides, which will not produce drug resistance, so silver nanoparticles Widely used in clinical antibacterial field. In particular, the synthesis of nanomaterials using the special structure and properties of polysaccharides has become an emerging research topic in the field of nanomaterial preparation, which has att...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00B82Y30/00
CPCB22F9/24B22F2009/245B82Y30/00B82Y40/00
Inventor 贾学伟许春平俞金伟姜宇孙懿岩
Owner ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
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