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A compound for preventing and treating Candida albicans and its preparation method and application

A technology of Candida albicans and compounds, applied in the field of biomedicine, can solve problems such as narrow antibacterial spectrum, high toxicity and side effects, and drug resistance of Candida albicans, and achieve the effect of promoting development and promoting development

Active Publication Date: 2020-06-12
SOUTH CHINA AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The drugs currently on the market for the treatment of Candida albicans are mainly azoles and polyenes, but these drugs have shortcomings such as narrow antibacterial spectrum and high toxicity to varying degrees; in addition, with the development of antifungal drugs The drug resistance of Candida albicans is becoming more and more prominent due to long-term and large-scale use

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  • A compound for preventing and treating Candida albicans and its preparation method and application
  • A compound for preventing and treating Candida albicans and its preparation method and application
  • A compound for preventing and treating Candida albicans and its preparation method and application

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Embodiment 1

[0029] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments, but the embodiments do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the technical field. Unless otherwise specified, the reagents and materials used in the present invention are commercially available. Example 1 Fermentative extraction of actinomycetes strains and preparation of 3-methyl-N-(2'-phenylethyl) butyramide compound

[0030] The actinomycete strain SCSIOT05 was isolated from the seabed sediments (E94°3364′, S1°4256′) at 4617m in the Indian Ocean, and the 16SrDNA gene sequence analysis confirmed that the strain was Streptomyces olivaceus. The gene sequence was saved to GenBank (accession number MF429815).

[0031] In-frame knockout construction of Streptomyces olivaceus SCSIO T05D△rsdK2 / △xmcP...

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Abstract

The invention belongs to the field of biomedicines and in particular relates to a compound for preventing and controlling candida albicans as well as a preparation method and application thereof. Thecompound provided by the invention is 3-methyl-N-(2'-phenemyl)butyramide; an actinomyces streptomyces olivaceus SCSIO T05deltarsdK2 / deltaxmcP mutant strain is constructed through in-frame deletion; amplified fermentation is carried out through a mutant strain fermentation tank, and bacterium collection and centrifuging are carried out; part of mycelia are subjected to ultrasonic extraction throughacetone and part of supernatant is extracted through butanone; extract is combined according to an HPLC (High Performance Liquid Chromatography) analysis result; the compound is obtained by separating through various column chromatography methods. Compared with the prior art, the compound provided by the invention has the beneficial effects that the technology disclosed by the invention successfully prepares and screens the compound 3-methyl-N-(2'-phenemyl)butyramide which has the effects of inhibiting the adhesion of the candida albicans, the mycelium shape transformation and the pathogenicity; meanwhile, the compound 3-methyl-N-(2'-phenemyl)butyramide has relatively small toxicity, does not influence the growth of the candida albicans and human cells and is hopeful to promote and propelthe development of treatment of novel anti-fungus medicines.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a compound for preventing and treating Candida albicans, a preparation method and application thereof. Background technique [0002] Candida albicans (Candida albicans) is a common conditional pathogen. When the human body's immunity is weakened, it will cause disease, and it will cause superficial and deep infection, and even threaten life. The drugs currently on the market for the treatment of Candida albicans are mainly azoles and polyenes, but these drugs have shortcomings such as narrow antibacterial spectrum and high toxicity to varying degrees; in addition, with the development of antifungal drugs The drug resistance of Candida albicans has become more and more prominent due to the long-term and large-scale use. Therefore, the development of new compounds against Candida albicans has become the first step in the research and development of antifungal drugs. [0003...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C233/05A61P31/10C12P13/02C12R1/58
CPCC07C233/05C12P13/02
Inventor 邓音乐鞠建华蒙丽丽孙长利赵朔孙秀云陈俐
Owner SOUTH CHINA AGRI UNIV
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