Huperzine A sustained release microspheres as well as preparation method and application thereof
A technology of huperzine A and slow-release microspheres, which is applied in the direction of block delivery, can solve the problems of unsatisfactory release effect, incomplete drug release, poor patient compliance, etc., and achieve excellent compressibility, fluidity and breathability The effect of good resistance and good powder properties
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Embodiment 1
[0039] The huperzine A sustained-release microspheres provided in this example are prepared by the following method:
[0040] According to the composition of the prescription shown in Table 1, a certain amount of huperzine A (theoretical drug loading accounts for 0.4% of the dry weight of the skeleton material), the skeleton material ethylcellulose (EC45) and poloxamer (F127), were dissolved in In 200ml of 80% v / v ethanol aqueous solution, the drug solution is prepared; wherein the concentration of the skeleton material ethylcellulose is 5% w / v, and the concentration of the skeleton material poloxamer is 0.20% w / v and 0.25% respectively w / v, 0.5% w / v.
[0041] The obtained drug solution was uniformly fed into UPPS to prepare huperzine A sustained-release microspheres, and three kinds of huperzine A sustained-release microspheres with different F127 contents were obtained. The instrument parameters used are: liquid supply rate 8ml / min, rotating disc rotation speed 9000rpm, vor...
Embodiment 2
[0045] The huperzine A sustained-release microspheres provided in this example are prepared by the following method:
[0046] According to the prescription composition shown in table 2, a certain amount of huperzine A (theoretical drug loading accounts for 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt% of the dry weight of the skeleton material respectively), the skeleton material ethyl fiber (EC45) and poloxamer 127 (F127), dissolved in 100ml of 80% v / v ethanol aqueous solution, to prepare a drug solution; wherein the concentration of the skeleton material ethylcellulose is 5% w / v, the skeleton material poloxamer The concentration of Loxamer 127 was 0.25% w / v.
[0047] The obtained drug solution was uniformly fed into UPPS to prepare huperzine A sustained-release microspheres, and four kinds of huperzine A sustained-release microspheres with different drug loadings were obtained. Wherein the instrument parameter used is identical with embodiment 1.
[0048] Table 2 contains the composition o...
Embodiment 3
[0051] The huperzine A sustained-release microspheres provided in this example are prepared by the following method:
[0052] According to the composition of the prescription shown in Table 3, a certain amount of huperzine A (theoretical drug loading accounts for 0.4wt% of the dry weight of the framework material) and the framework material are dissolved in 100ml of 80% v / v ethanol aqueous solution to prepare Drug solution; wherein the concentration of framework material A is 5% w / v, and the concentration of framework material B is 0.25% w / v.
[0053] The obtained drug solution was uniformly fed into UPPS to prepare huperzine A sustained-release microspheres, and four kinds of huperzine A sustained-release microspheres with different compositions were obtained. Wherein the instrument parameter used is identical with embodiment 1.
[0054] The prescription composition of table 3 huperzine A sustained-release microspheres
[0055] prescription
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