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Temperature-sensing gold nano cage and preparation method and application thereof, drug-loaded temperature-sensing gold nano cage and preparation method thereof

A gold nano-cage and nano-cage technology are applied in the fields of temperature-sensitive gold nano-cages and preparation, drug-loaded temperature-sensitive gold nano-cages and preparation fields, which can solve the problems of inability to cure tumors, lack of targeting, uneven thermal distribution, etc. In vivo clearance, improved stability, high reproducibility

Active Publication Date: 2018-05-15
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the uneven heat distribution inside the tumor, a single photothermal therapy is not enough to kill all tumor cells, resulting in incomplete tumor ablation and tumor recurrence, while single drug chemotherapy has no targeting, and side effects are large, and it cannot cure the tumor

Method used

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  • Temperature-sensing gold nano cage and preparation method and application thereof, drug-loaded temperature-sensing gold nano cage and preparation method thereof
  • Temperature-sensing gold nano cage and preparation method and application thereof, drug-loaded temperature-sensing gold nano cage and preparation method thereof
  • Temperature-sensing gold nano cage and preparation method and application thereof, drug-loaded temperature-sensing gold nano cage and preparation method thereof

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preparation example Construction

[0043] According to the second aspect of the present invention, the present invention provides the preparation method of the above-mentioned temperature-sensitive gold nanocages, comprising the following steps: first mixing the temperature-sensitive liposomes with the gold nanocages, so that the temperature-sensitive liposomes are coated on the gold nanocages The outer surface of the thermosensitive gold nanocage is made;

[0044] Preferably, the mass ratio of thermosensitive liposomes and gold nanocages is (45-60): 1, preferably (48-52): 1;

[0045] Preferably, the temperature-sensitive liposome is coated on the outer surface of the gold nanocage by ultrasonic dispersion, so as to obtain the temperature-sensitive gold nanocage.

[0046] In the present invention, a typical but non-limiting preparation method of temperature-sensitive gold nanocages includes the following steps: firstly, gold nanocages are dispersed in a solution, and then temperature-sensitive liposomes are add...

Embodiment 1

[0077] This embodiment provides a temperature-sensitive gold nanocage, comprising a hollow porous gold nanocage with a particle size of 70nm, and the outside of the gold nanocage is coated with a temperature-sensitive liposome layer with a thickness of 3nm, the temperature-sensitive liposome layer Consisting of (1,2 distearoylcholine-sn-glycerol-3-phosphoethanolamine-maleimide)-polyethylene glycol, dipalmitoylphosphatidylcholine, dimyristoylphosphatidylcholine Alkali and cholesterol, the mass ratio of the four is 8:1:3:5.

Embodiment 2

[0079] This embodiment provides a temperature-sensitive gold nanocage. The difference between this embodiment and Example 1 is that the thickness of the temperature-sensitive liposome layer is 8nm, and the temperature-sensitive liposome layer is composed of (1,2 dihard Esterylcholine-sn-glycerol-3-phosphoethanolamine-maleimide)-polyethylene glycol, dipalmitoylphosphatidylcholine, dimyristoylphosphatidylcholine and cholesterol, The mass ratio of the four is 12:2:1:7.

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Abstract

The invention provides a temperature-sensing gold nano cage and a preparation method and an application thereof, a drug-loaded temperature-sensing gold nano cage and a preparation method thereof, which belong to the technical field of a drug carrier. The gold nano cage is in a hollow porous structure, an external surface of the gold nano cage is coated with a temperature-sensing liposome, the problem that a single photo-thermal treatment in the prior art cannot kill all the tumor cells, single medicine chemotherapy does not have targeting performance, and side effect is large, by taking the gold nano cage as a drug carrier and an optothermal agent, the medicine can realize high-efficiency targeting transmission in body and photo-thermal treatment on tumors; the external surface of the goldnano cage is coated with the temperature-sensing liposome, the photo-thermal conversion performance of the gold nano cage is used, temperature of the temperature-sensing liposome is increased to phase-transition temperature, and the medicine can be rapidly released, so that the photo-thermal-medicine combined high-efficiency controllable malignant tumor treatment effect can be achieved.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to a temperature-sensitive gold nanocage and its preparation method and application, a drug-loaded temperature-sensitive gold nanocage and its preparation method. Background technique [0002] At present, malignant tumors are still one of the major diseases that threaten human life and health, and the incidence of cancer worldwide is on the rise. The treatment of malignant tumors has always been a difficulty in research at home and abroad. The methods of clinical treatment of cancer include surgery, radiation therapy, photothermia and drug chemotherapy. Photothermal therapy has attracted widespread attention due to its ability to significantly improve the anti-tumor effect of drugs. Its principle is to use targeting technology to gather photothermal agents with high photothermal conversion efficiency near the tumor tissue, and convert the photothermal agent under the irradiati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/127A61P35/00
CPCA61K9/127A61K41/0028A61K41/0052A61K2300/00
Inventor 蔡林涛韩志群梁锐晶郑明彬刘陈立
Owner SHENZHEN INST OF ADVANCED TECH
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