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Enhanced dihydromyricetin soluble complex and preparation method thereof

A dihydromyricetin and compound technology, which is applied in the direction of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of failing to reach the water solubility and stability of dihydromyricetin and other issues, to achieve the effect of enhancing pharmacological effects, strong antioxidant activity, and enhancing curative effect

Inactive Publication Date: 2018-05-11
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another component stevioside (also known as stevioside, CAS registration number 57817-89-7, molecular formula C 38 h 60 o 18 , molecular weight 804.87), then fail to achieve the effect of simultaneously improving the water solubility and stability of dihydromyricetin

Method used

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  • Enhanced dihydromyricetin soluble complex and preparation method thereof
  • Enhanced dihydromyricetin soluble complex and preparation method thereof
  • Enhanced dihydromyricetin soluble complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Put 50mg of dihydromyricetin and 900mg of rebaudioside A in a 100mL round-bottomed flask, add 50mL of absolute ethanol, after fully dissolving, evaporate the absolute ethanol in a 40°C water bath in a rotary vacuum and recover the ethanol to obtain dihydromyricetin and Uniformly dispersed dihydromyricetin complex of rebaudioside A.

Embodiment 2

[0021] Put 20mg of dihydromyricetin and 300mg of rebaudioside A in a 100mL round-bottomed flask, add 30mL of absolute ethanol, after fully dissolving, evaporate the absolute ethanol in a 40°C water bath in a rotating vacuum and recover the ethanol to obtain dihydromyricetin and Uniformly dispersed dihydromyricetin complex of rebaudioside A.

Embodiment 3

[0023] Put 100mg of dihydromyricetin and 3000mg of rebaudioside A in a 100mL round bottom flask, add 70mL of absolute ethanol, after fully dissolving, evaporate the absolute ethanol in a 40°C water bath in a rotary vacuum and recover the ethanol to obtain dihydromyricetin and Uniformly dispersed dihydromyricetin complex of rebaudioside A.

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Abstract

The invention discloses a dihydromyricetin complex with synergistically enhanced pharmacodynamic effects. The dihydromyricetin complex comprises dihydromyricetin as a main drug and is characterized inthat the dihydromyricetin complex comprises rebaudioside A as a drug adjuvant, a mass ratio of the dihydromyricetin main drug to the rebaudioside A drug adjuvant is 1: 15 to 1: 30, and the rebaudioside A (with a CAS register number of 58543-16-1, a molecular formula C44H70O23 and molecular weight of 967.03) has purity of greater than or equal to 98%. In the aqueous solution, the rebaudioside A spontaneously forms micelles to solubilize dihydromyricetin, the solubility of dihydromyricetin is 16.57 mg / ml, the micelle has small particle sizes, a distribution range is uniform, the drug stabilityis good, the dihydromyricetin absorption after oral administration is observably improved, the oral bioavailability is improved, the rebaudioside A has activity to resist diabetes and diminish inflammation and the dihydromyricetin complex has good synergistic pharmacological activity. A preparation method of the dihydromyricetin complex has simple processes, is suitable for large-scale industrialproduction and has good economical efficiency.

Description

technical field [0001] The invention relates to a soluble compound of dihydromyricetin, in particular to a soluble compound of dihydromyricetin with the effect of synergistically enhancing drug efficacy and a preparation method thereof. Background technique [0002] Dihydromyricetin (Dihydromyricetin, CAS No. 27200-12-0) is a polyphenolic hydroxyl dihydroflavonol widely present in natural plants, also known as snake grapevine and dihydromyricetin, belonging to flavonoids , Dihydromyricetin has various pharmacological activities such as prevention and treatment of cardiovascular diseases, anti-tumor, anti-oxidation, etc., has good medicinal value, and has great potential for development. The latest research shows that because dihydromyricetin has a wide range of pharmacological activities such as significant anti-oxidation, anti-inflammation, and free radical scavenging, it has broad application prospects in the treatment of diabetes and its complications, such as diabetic ke...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/704A61K47/26A61K9/107A61P3/10A61P25/00A61P27/02
CPCA61K47/26A61K9/1075A61K31/352A61K31/704A61K2300/00
Inventor 吴祥根侯玉真汝绍刚金宏
Owner QINGDAO UNIV OF SCI & TECH
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