Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of oral pharmaceutical preparation with sustained release effect and preparation method thereof

A pharmaceutical preparation and oral cavity technology, which is applied in the field of pharmaceutical preparation, can solve the problem that oral bactericidal drugs cannot obtain the ideal slow-release effect, and achieve the effect of inhibiting the growth of oral bacteria and prolonging the release time

Active Publication Date: 2021-06-18
GUANGZHOU LIBY
View PDF9 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cyclodextrin and ethyl cellulose are the most commonly used drug-encapsulating carriers. Although they are widely used, they cannot actually achieve the desired sustained-release effect for oral antiseptic drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of oral pharmaceutical preparation with sustained release effect and preparation method thereof
  • A kind of oral pharmaceutical preparation with sustained release effect and preparation method thereof
  • A kind of oral pharmaceutical preparation with sustained release effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The preparation method of above-mentioned oral pharmaceutical preparation, comprises the following steps:

[0045] The ethanol solvent is used to dissolve and disperse 5-20 parts of the controlled-release agent, 60-90 parts of the forming agent and 5-20 parts of the bactericidal drug to obtain a sample stock solution with a mass fraction of 5%-20%.

[0046] And through the spray dryer, the parameters are set as follows:

[0047] Injection rate 10-40mL / min, air volume 50-70m 3 / h, atomization air pressure 0.1-0.2Mpa, air inlet temperature 140-160°C, needle pass frequency 60S, and powder particles were prepared.

Embodiment 1

[0050] A preparation method of an oral pharmaceutical preparation with sustained-release effect, comprising the following process steps:

[0051] Add 10 parts of cetylpyridinium chloride, 30 parts of triacetyl-β-cyclodextrin, 50 parts of ethyl cellulose, and 10 parts of stearic acid into the beaker, and add 75% ethanol solution, heat and stir at 40°C until Mix evenly to obtain a sample stock solution with a mass fraction of 10%, and pass it through a spray dryer. The parameters are set as follows: sample injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

Embodiment 2

[0053] A preparation method of an oral pharmaceutical preparation with sustained-release effect, comprising the following process steps:

[0054] Add 15 parts of cetylpyridinium chloride, 75 parts of ethyl cellulose, and 10 parts of stearic acid into a beaker, and add 75% ethanol solution, heat at 40°C and stir until evenly mixed to obtain a sample with a mass fraction of 10% Stock solution, and through the spray dryer, the parameters are set as follows: injection rate 10mL / min, air volume 60m 3 / h, atomization air pressure 0.1Mpa, air inlet temperature 140°C, needle pass frequency 60S, and powder particles with a particle size of 5 μm were prepared.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses an oral medicine preparation with sustained release effect, which can be released continuously within 8 hours, and still has effective antibacterial effect within 8 hours. In terms of parts by mass, the pharmaceutical preparation includes 5-20 parts of the controlled-release agent, 60-90 parts of the forming agent, and 5-20 parts of the bactericidal drug. The present invention unexpectedly finds that the release time of the cationic fungicide can be prolonged by adding an appropriate release-controlling agent to prevent the loss of the drug caused by the early "burst release" of the drug, and the amount of the drug released in the first hour can be reduced to 1 / 6 times, ensuring Subsequent sustained release of drug. The slow-release effect of the drug in the oral pharmaceutical preparation can inhibit the growth of oral bacteria for a longer period of time, that is, achieve a long-term antibacterial effect.

Description

technical field [0001] The invention relates to an oral pharmaceutical preparation, which belongs to the technical field of medicine preparation, in particular to an oral pharmaceutical preparation with sustained release effect and a preparation method thereof. Background technique [0002] Modern medical research believes that the existence of bacteria is a prerequisite for the occurrence of oral diseases, and the pathogenicity of bacteria mainly depends on the existence of oral biofilm, that is, dental plaque. Dental plaque is a major factor in the inflammatory response of teeth and surrounding tissues, leading to two of the most common diseases of the oral cavity: dental caries and periodontal disease. Dental plaque has a complex bacterial group structure, its deep texture is dense, oxygen is scarce, and the acid formed is not easily diluted by saliva. Once the bacteria form a biofilm, the bacteria will gain a strong resistance that free bacteria do not have. [0003] Dr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/12A61K47/14A61K9/16A61K31/44A61K31/155A61K31/14A61P1/02A61P31/04A61P31/02A61K8/36A61K8/37A61K8/49A61K8/43A61K8/41A61Q11/00A61Q17/00
CPCA61K8/361A61K8/37A61K8/375A61K8/416A61K8/43A61K8/4926A61K9/1617A61K31/14A61K31/155A61K31/44A61Q11/00A61Q17/005
Inventor 陈伟才易丹李淑钰刘亚军
Owner GUANGZHOU LIBY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com