A kind of preparation method of Fenghan Shuangliguai tablets

A kind of wind-cold and Aconitum-making technology, which is applied in the field of medicine, can solve the problems of the clinical application constraints of Aconitum, the burden of liver metabolism of patients, and the narrow range of safe doses, etc., and achieve the effects of inhibition of platelet aggregation rate, easy product quality, and easy clinical application

Active Publication Date: 2021-07-16
黑龙江参鸽药业有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The diester-type alkaloids in Aconitum Aconitum are both medicinal and toxic components. Improper use can lead to serious adverse reactions in patients. Therefore, the clinical application of Aconitum Aconiti is greatly restricted.
Due to the narrow range of safe doses of Aconitum, improper use will lead to serious adverse reactions in patients, so the clinical application of Aconitum is greatly restricted
Aconitum is widely used in medicine because of its functions of restoring yang and resuscitating adverse events, warming the middle and tonifying the kidney, dispelling cold and relieving pain, etc. poisoning and death
There is no research on this
Moreover, the daily dosage of Fenghan Shuangliguai Tablets currently available in the market is large, about 2g per day, which creates a burden on the liver metabolism of patients
In addition, the commercially available Fenghan Shuangliguai Tablets contain the whole powder of Qiwei herbs, which are prone to mildew and bacterial growth during storage, making it difficult to control the quality.

Method used

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  • A kind of preparation method of Fenghan Shuangliguai tablets
  • A kind of preparation method of Fenghan Shuangliguai tablets
  • A kind of preparation method of Fenghan Shuangliguai tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 The preparation method of Fengchi Shuangliguai tablet of the present invention

[0040] Prescription: 81g of maple bark, 40g of safflower, 81g of Qiannianjian, 24g of Zhichuanwu, 81g of Fangfeng, 24g of Zhicaowu, 40g of frankincense, 8g of Zhinuxue, 81g of fungus and 40g of myrrh.

[0041] Preparation:

[0042] Step 1: Add ground maple bark, Qiannianjian, Fangfeng, frankincense and myrrh powder into supercritical CO 2 In the extraction tank, the pressure is 20MPa, the extraction temperature is 50°C, CO 2 The flow rate is 10L / h, the extraction time is 2h, the volatile oil is collected, and the dregs are used for later use;

[0043] Step 2: making Aconitum aconitifolia and Nuxychia chinensis, adding 10 times the amount of 70% ethanol, extracting 3 times, 2 hours each time, combining the extracts, recovering the ethanol, and recovering the liquid medicine and dregs of the ethanol for later use;

[0044] Step 3: Safflower, Aconiti officinale and fungus, and...

Embodiment 2

[0046] Embodiment 2 The preparation method of Fengchi Shuangliguai tablet of the present invention

[0047] Prescription: 81g of maple bark, 40g of safflower, 81g of Qiannianjian, 24g of Zhichuanwu, 81g of Fangfeng, 24g of Zhicaowu, 40g of frankincense, 8g of Zhinuxue, 81g of fungus and 40g of myrrh.

[0048] Preparation:

[0049] Step 1: Add ground maple bark, Qiannianjian, Fangfeng, frankincense and myrrh powder into supercritical CO 2 In the extraction tank, the pressure is 20MPa, the extraction temperature is 50°C, CO 2 The flow rate is 10L / h, the extraction time is 2h, the volatile oil is collected, and the dregs are used for later use;

[0050] Step 2: making Aconitum aconitifolia and Nuxychia chinensis, adding 10 times the amount of 70% ethanol, extracting 3 times, 2 hours each time, combining the extracts, recovering the ethanol, and recovering the liquid medicine and dregs of the ethanol for later use;

[0051] Step 3: Safflower, Aconiti officinale and fungus, an...

Embodiment 3

[0053] Example 3 Extraction of maple bark, millennium, windproof, frankincense and myrrh volatile oil

[0054] Taking the yield of volatile oil as an index, the main factors affecting the extraction effect, such as extraction pressure, extraction temperature, and extraction time, were investigated by orthogonal test method. The factors and level design are shown in Table 1.

[0055] Table 1 Factor level table

[0056]

[0057] Test method: Weigh 81g of maple bark, 81g of Qiannianjian, 81g of Fangfeng, 40g of frankincense and 40g of myrrh, grind them into coarse powder, and extract according to the test method in Table 1.

[0058] Table 2 Orthogonal table for the extraction of volatile oils from maple bark, Qiannianjian, Fangfeng, frankincense and myrrh

[0059]

[0060] Table 3 Variance analysis table of volatile oil yield

[0061]

[0062] From the results in Table 3, it can be seen that the main factor affecting the extraction results is that the extraction pres...

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Abstract

The invention provides a preparation method of Fenghan Shuangliguai Tablets. The preparation method controls the content of alkaloid components of Aconitum aconitum, Aconitum aconitum and Nuxychnium chinensis, has better drug efficacy, can reduce dosage, and is easy to store And easy to carry out quality control. The preparation method comprises the following steps: Step 1: Adding maple bark, Qiannianjian, Fangfeng, frankincense and myrrh powder into supercritical CO 2 In the extraction pool, extract and collect volatile oil, and prepare the dregs for later use; step 2: make Aconitum aconitifolia and Nuxychia chinensis, carry out alcohol extraction, combine the extracts, recover ethanol, and recover the medicinal liquid and dregs for later use; step 3: red Add water to extract the flowers, Aconiti officinalis and fungus, and the above medicinal residues, add water to extract and combine the decoction, filter, concentrate, and obtain a dry extract; step 4: crush the dry extract, add an appropriate amount of starch, mix well, sieve, and spray into The volatile oil is mixed evenly, compressed into tablets, coated with sugar or film, and ready to use.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of Fenghan Shuangliguai tablets. Background technique [0002] Fenghan Shuangliguai Tablets are composed of 81g of maple bark, 40g of safflower, 81g of Qiannianjian, 24g of Zhichuanwu, 81g of Fangfeng, 24g of Zhicaowu, 40g of frankincense, 8g of Zhinuxue, 81g of fungus and 40g of myrrh. The composition of the medicine can dispel wind and cold, promote blood circulation and dredge collaterals. It is used for arthralgia caused by wind-cold blockage and blood stasis blocking collaterals. Symptoms include joint pain, waist and leg pain, cold pain or tingling pain, local chills and aversion to wind, numbness of limbs, and difficulty in flexion and extension. The first part of the 2015 edition of "Chinese Pharmacopoeia" records the standard of Fenghan Shuangguai Tablets. The core weight of the tablet is 0.3g. The preparation method is as follows: the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K36/888A61K9/24A61K47/69A61P19/02A61P29/00
CPCA61K9/209A61K9/2806A61K36/07A61K36/238A61K36/286A61K36/324A61K36/328A61K36/56A61K36/57A61K36/714A61K36/888A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 朱风堂
Owner 黑龙江参鸽药业有限公司
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