Novel application of glycosyl modified polyphenol compounds
A polyphenolic compound and glycosyl modification technology, which is applied in the direction of effective components of hydroxyl compounds, drug combinations, anti-toxins, etc., can solve the problem that the pathogenesis of pulmonary fibrosis is not completely clear, the disease cannot be fundamentally treated, and the treatment effect is not good, etc. problems, achieve good lung protective function, good anti-oxidation effect, reduce oxidative stress and inflammatory response
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0048] Example 1 Preparation of glycosyl-modified polyphenolic compounds (R=H)
[0049] Take 1.8D-xylose, 9.4g pyrogallic acid, heat to 130°C to melt, stir and react for 24h, purify and separate to obtain 4.0g of glycosyl-modified polyphenol compound (R=H), the yield is 87.0%.
Embodiment 2
[0050] Example 2 Preparation of glycosyl-modified polyphenolic compounds (R=CH 3 )
[0051] Take 3.8g of the glycosyl-modified polyphenol compound (R=H) prepared in Example 1, add 20ml of ethanol, then add 1.4g of anhydrous potassium carbonate and 8.6g of methyl iodide, stir and react at 60°C for 5h, purify and separate to obtain glycosyl-modified 4.0g of polyphenolic compounds (R=CH 3 ), yield 86.4%.
Embodiment 3
[0053] The in vivo experimental process of the glycosyl-modified polyphenol compound obtained in Example 1 of the present invention for treating lung injury in mice caused by acute paraquat poisoning includes the following steps:
[0054] 42 Kunming mice were randomly divided into blank control group, model group (paraquat 300mg / kg), positive control group (paraquat 300mg / kg+vitamin C100mg / kg), low-dose treatment group (paraquat group 300mg / kg+sugar Glycosyl-modified polyphenol compound 200mg / kg), medium-dose treatment group (paraquat group 300mg / kg+glycosyl-modified polyphenol compound 400mg / kg), high-dose treatment group (paraquat group 300mg / kg+glycosyl-modified polyphenol compound 800mg / kg). The paraquat stock solution was diluted with distilled water, administered orally, and the positive control group was intraperitoneally injected with vitamin C injection 24 hours after exposure. Saline solution, the blank control group and the model group were orally gavaged with the...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com