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Metal phthalocyanine and application thereof in fields of photothermal materials and photothermal therapy

A metal phthalocyanine and metal technology, which is applied in the field of photothermal agents and photothermal therapy drugs, can solve the problems of limited and unseen photothermal therapy application research, and achieve the goal of broadening applications, good photothermal effect, and high photothermal effect Effect

Active Publication Date: 2018-04-17
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in terms of cancer treatment, the research on phthalocyanine is currently limited to photodynamic therapy (PDT), and there is no application research on it as photothermal therapy.

Method used

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  • Metal phthalocyanine and application thereof in fields of photothermal materials and photothermal therapy
  • Metal phthalocyanine and application thereof in fields of photothermal materials and photothermal therapy
  • Metal phthalocyanine and application thereof in fields of photothermal materials and photothermal therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Synthesis of tetracarboxyl substituted cobalt phthalocyanine complexes with the following structure

[0053] in:

[0054] (1) prepare the phthalonitrile derivative of following formula of structure:

[0055]

[0056] With 3-nitrophthalonitrile (20mmol) and p-hydroxybenzoic acid (20-70mmol, preferably 60mmol) as reactants, dimethyl sulfoxide (40-200mL, preferably 140mL) as solvent, in potassium carbonate ( In the presence of 30-90 mmol, preferably 80 mmol) and nitrogen protection, the reaction was stirred at room temperature to 60°C (preferably 60°C) for 24-72 hours, and monitored by thin-layer chromatography. After the reaction, the reaction solution was poured into ice water, and part of the pale yellow precipitate was precipitated, filtered, and the filter residue was collected, and the filtrate was washed with CHCl 3 Extraction, and then back extract the extract with water, CHCl 3 The extract was rotary evaporated and dried under vacuum at room temperature ...

Embodiment 2

[0066] Synthesis of tetracarboxyl substituted nickel phthalocyanine complexes with the following structure

[0067] in:

[0068] Preparation of tetrasubstituted carboxyl nickel phthalocyanine complex: with the phthalonitrile derivative (2mmol) described in the above-mentioned Example 1 (1) as the reactant, n-amyl alcohol (20-34mL, preferably 30mL) as the solvent, add Nickel chloride (1~4mmol, preferably 2mmol), with 1,8-diazabicyclo[5.4.0]undec-7-ene (0.4~1.2mL, preferably 0.6mL) as catalyst, 130~150 Stir the reaction at ℃ for 12-48 hours, monitor the end point of the reaction by thin-layer chromatography, and generate the corresponding nickel phthalocyanine complex. After the reaction, evaporate to dryness, dissolve with a small amount of DMF, pass through a silica gel column, remove yellow impurities with ethyl acetate, collect the target band with DMF / acetic acid (20 / 1), and evaporate to dryness. Add a small amount of DMF to dissolve, add water to precipitate, and dry...

Embodiment 3

[0071] Using manganese chloride instead of copper chloride in Example 1, the corresponding tetracarboxy substituted manganese phthalocyanine complex can be obtained.

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PUM

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Abstract

The invention discloses a metal phthalocyanine and application thereof in the fields of photothermal materials and photothermal therapy. Irradiated by near-infrared laser, a solution containing the metal phthalocyanine disclosed by the invention has a remarkable photothermic effect, capable of implementing photothermal therapy, and the metal phthalocyanine can be used as a photothermal material orto prepare medicines with the effect of photothermal therapy, and is of great significance for the development of multifunctional phototherapeutic medicines.

Description

technical field [0001] The invention belongs to the field of photothermal agents and photothermal therapeutic drugs, and specifically relates to three types of cobalt phthalocyanine, nickel phthalocyanine and manganese phthalocyanine complexes and applications thereof. Background technique [0002] With the development of science and technology, new tumor treatment methods continue to emerge. Among them, photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted extensive attention and research due to their high selectivity to tumor tissue, small trauma, and low toxicity and side effects. [0003] PDT kills cancer cells by using photosensitizers to generate reactive oxygen species (Reactive oxygen species, ROS) under light. According to the type of ROS and the way of production, PDT can be divided into two mechanisms: type I and type II. In the type I mechanism, the excited-state photosensitizer directly undergoes electron transfer with biomolecules to genera...

Claims

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Application Information

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IPC IPC(8): C07D487/22A61K41/00A61P35/00
CPCA61K41/0076C07D487/22
Inventor 黄剑东彭小慧汤吉林
Owner FUZHOU UNIV
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