Stannous sulfide nanosheet based drug delivery system and preparation method thereof
A technology of stannous sulfide and drug delivery system, applied in the field of tumor treatment, can solve the problem of high price of black phosphorus, and achieve the effects of high clinical value, good light absorption, and simple preparation
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Embodiment 1
[0039] A preparation method of a drug delivery system based on stannous sulfide nanosheets, comprising the following steps:
[0040] (1) After the stannous sulfide block was ground for 30 minutes, it was dispersed in isopropanol to obtain a dispersion with a concentration of 1 mg / mL; the above-mentioned dispersion was ultrasonicated for 5 hours by a probe, and the probe power of the ultrasonic probe was 360w , the temperature of the probe is maintained at 5-20°C during the ultrasonic process, and when the temperature rises during the period, an ice pack is used to cool down; then the dispersion is ultrasonicated in a water bath for 10 hours to obtain the ultrasonic dispersion, and the water bath ultrasonic Keep the temperature at 15-25°C. When the temperature of the water bath rises, change the water to ensure that the temperature of the water bath is within the range of 15-25°C; after centrifuging the ultrasonic dispersion, centrifuge at a speed of 5000 rpm for 0.5 h, take th...
Embodiment 2
[0045] A preparation method of a drug delivery system based on stannous sulfide nanosheets, comprising the following steps:
[0046] (1) After the stannous sulfide block was ground for 40 minutes, it was dispersed in nitrogen-methylpyrrolidone to obtain a dispersion with a concentration of 1 mg / mL; the above-mentioned dispersion was ultrasonicated for 6 hours by a probe, and the probe power of the ultrasonic probe was 360w, the temperature of the probe is maintained at 10-15°C during the ultrasonic process, and when the temperature rises during the period, use an ice pack to cool down; then the dispersion liquid is ultrasonicated in a water bath for 12 hours to obtain the ultrasonic dispersion liquid, and the water bath ultrasonic Keep the temperature of the water bath at 15-25°C. When the temperature of the water bath rises, change the water to ensure that the temperature of the water bath is within the range of 15-25°C; centrifuge the ultrasonically dispersed liquid at a spee...
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