Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Acid-sensitive iron carbide nanometer material, preparation method and applications thereof

A technology of nanomaterials and iron carbide, which is applied in the field of nanomaterials and biomedicine to achieve the effects of convenient timely diagnosis, strong acid sensitivity, and strong imaging effect

Inactive Publication Date: 2018-04-13
ZHEJIANG UNIV OF TECH
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Tumor has become one of the diseases that seriously threaten human health in the world. In 2012, there were about 14.1 million new cancer cases worldwide and 8.2 million cancer deaths. Tumors often have greater side effects on normal tissues at the same time, therefore, there is an urgent need to develop new technologies that can selectively treat tumors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Acid-sensitive iron carbide nanometer material, preparation method and applications thereof
  • Acid-sensitive iron carbide nanometer material, preparation method and applications thereof
  • Acid-sensitive iron carbide nanometer material, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 2.6g octadecylamine, 0.06mmolNH 4 Br and 0.5mL oleylamine were added to the four-neck flask, and vacuumized for 1h under magnetic stirring; the temperature was raised to 140°C and kept for 60min, and then 0.5mL Fe(CO) 5 Inject into the reaction solution and keep at 180°C for 30 minutes; after the reaction is completed and the temperature is lowered to room temperature, the product is poured out, and the product is washed 3 times with a mixed solvent with a volume ratio of n-hexane and ethanol of 1:3, and the centrifugation speed is 10000r / min. Put it in 4mL of n-hexane for later use; take 10mL of octadecene and put it into a four-necked flask, vacuumize it at 90°C for 1h under magnetic stirring, and fill it with argon atmosphere; inject the n-hexane solution in step C into the four-necked flask, at 100°C Keep it for 1h, then continue to heat up at 280°C for 0.5h. After the reaction was completed and cooled down to room temperature, the product was poured out, and...

Embodiment 2

[0044] Weigh about 5mg Fe 2C Dissolve nanoparticles in 5mL chloroform, sonicate for 5min; weigh 10mg polyethylene glycol, dissolve it in 5mL chloroform, sonicate for 5min, slowly drop it into the nanoparticle chloroform solution, sonicate for 30min, spin the needle at 40°C for 1.5h, add 30mL pH4. 0 buffer solution, take 1.5mL at each time point, centrifuge at 12000r / min to take 1mL supernatant and put it in a glass bottle, and measure the iron ion concentration.

[0045] image 3 It can be seen that at pH 4.0, the iron release rate reached 69.05% after 4 hours, and the release rate was very fast.

Embodiment 3

[0047] Weigh about 5mg Fe 2 C Dissolve nanoparticles in 5mL chloroform, sonicate for 5min; weigh 10mg polyethylene glycol, dissolve in 5mL chloroform, sonicate for 5min, slowly drop it into the nanoparticle chloroform solution, sonicate for 30min, spin the needle at 40°C for 1.5h, add 30mL pH6. 5 buffer solution, take 1.5mL at each time point, centrifuge at 12000r / min to take 1mL supernatant and put it in a glass bottle, and measure the iron ion concentration.

[0048] Figure 4 It can be seen that at pH 6.5, the iron release rate is 6.3% after 4 hours, indicating that the iron release rate is very small in the neutral range, and it can be used as an acid-sensitive response material.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
sizeaaaaaaaaaa
sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses an acid-sensitive iron carbide nanomaterial, which is characterized in that the iron carbide nanomaterial is a core-shell structure consisting of an outer layer and an inner layer, the outer layer is Fe3O4, and the inner layer is FexC, wherein X=1- 3. Iron carbide nanomaterials are obtained by thermally decomposing carbonyl iron at high temperature under the induction of halogen. The iron carbide provided by the present invention has stronger acid sensitivity than other materials such as ferroferric oxide. Iron carbide nanoparticles release ferrous ions in tumor cells, and undergo disproportionation reaction with H2O2 to generate hydroxyl radicals to kill tumor cells. Tumor cells; iron carbide nanomaterials have a stronger T2 imaging effect than other nanomaterials such as ferric oxide 128mM‑1s‑1, which is convenient for timely diagnosis during treatment and improves the effect of tumor treatment.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials and biomedicine, and specifically relates to an acid-sensitive iron carbide nanomaterial and its preparation method and application. The acid-sensitive iron carbide nanomaterial has T 2 Magnetic resonance imaging capabilities. Background technique [0002] Tumor has become one of the diseases that seriously threaten human health in the world. In 2012, there were about 14.1 million new cancer cases worldwide, and the number of cancer deaths reached 8.2 million. Tumors often have side effects on normal tissues. Therefore, it is urgent to develop new technologies that can selectively treat tumors. [0003] Improving the sensitivity and accuracy of diagnosis can help improve the efficiency of subsequent medical treatment. Iron carbide nanomaterials are ideal biomedical materials, and their unique magnetic properties and comprehensive design capabilities can be applied in fields such as cell lo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K47/58A61K47/64A61K33/26A61P35/00
CPCA61K49/1878A61K33/26
Inventor 余靓车声雷高伟良赵帆应耀李涓乔梁郑精武李旺昌
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com