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Leech capsule

A technology of leeches and capsules, which is applied in the fields of capsule transportation, medical raw materials derived from leeches/worms, blood diseases, etc., and can solve the problems of low dissolution rate of hirudin

Inactive Publication Date: 2018-04-06
广西鹿帅仁生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a leech capsule, which can solve the problem of low hirudin dissolution rate when the leech pulverized components in the existing leech capsule are taken orally by the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1——leech capsule

[0020] It is prepared by a process comprising the following steps:

[0021] A. Do not feed the freshly caught leech, and make it drain the feces in its body;

[0022] B. the leech processed through A step is put into concentration and is soaked in the salt water of 0.3wt%, pulls out after it dies, dries, and blows off the impurity on the leech surface body by blowing;

[0023] C. Crush the leech obtained by drying in step B and put it into ethanol with a concentration of 50%, and seal and soak it; one month before the seal soak, put it in the ultrasonic power of 40W every day, the ultrasonic frequency is 20KHz, and the ultrasonic temperature is 25°C Under the condition of sonication for 20min;

[0024] D. Concentrate and dry the obtained substance through sealing and soaking in step C, and remove the ethanol component contained therein;

[0025] E. Mix the material obtained in step D with sodium fructose diphosphate and starch, and pass ...

Embodiment 2

[0027] Embodiment 2——leech capsule

[0028] It is prepared by a process comprising the following steps:

[0029] A. Do not feed the freshly caught leech, and make it drain the feces in its body;

[0030] B. put the leech processed through step A into a concentration of 0.5 wt% and soak it in salt water, take it out after it dies, dry, and blow off the impurities on the leech surface by blowing;

[0031] C. Crush the leech obtained by drying in step B and put it into ethanol with a concentration of 60%, and seal and soak it; one month before the seal soak, apply it every day at an ultrasonic power of 50W, an ultrasonic frequency of 30KHz, and an ultrasonic temperature of 45°C Under the condition of sonication for 40min;

[0032] D. Concentrate and dry the obtained substance through sealing and soaking in step C, and remove the ethanol component contained therein;

[0033] E. Mix the material obtained in step D with sodium fructose diphosphate and starch, and pass through a 2...

Embodiment 3

[0035] Embodiment 3 - leech capsule

[0036] It is prepared by a process comprising the following steps:

[0037] A. Do not feed the freshly caught leech, and make it drain the feces in its body;

[0038] B. put the leech processed through step A into concentration and soak in salt water of 0.4 wt%, pull out after it dies, dry, and blow off the impurities on the surface of the leech by blowing;

[0039] C. Crush the leech obtained by drying in step B and put it into ethanol with a concentration of 55%, and seal and soak it; one month before sealing and soaking, apply ultrasonic power to it every day at 46W, ultrasonic frequency at 26KHz, and ultrasonic temperature at 35°C Under the condition of sonication for 30min;

[0040] D. Concentrate and dry the obtained substance through sealing and soaking in step C, and remove the ethanol component contained therein;

[0041] E. Mix the material obtained in step D with sodium fructose diphosphate and starch, and pass through a 18-m...

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PUM

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Abstract

The invention relates to a leech capsule, and belongs to the technical field of leech deep processing. The preparation method comprises the following steps: removing excrements in leeches, soaking leeches in brine, after leeches die, fishing out leeches, blowing off impurities on the surface of leeches; grinding dried leeches, soaking grinded leeches in ethanol, carrying out sealed soaking; aftersealed soaking, concentrating and drying obtained substance to remove ethanol in the substance; mixing the substance with fructose sodium diphosphate and starch, sieving the mixture by a sieve with asize of 10-20 meshes, drying the mixture at a temperature of 30 to 45 DEG C, carrying out granulation and sterilization, and finally filling granules into capsules. At first, leeches are soaked in brine to change the tension force of the surface cells of leeches, then leeches are grinded, soaked in ethanol, concentrated, and dried so that hirudin is dissolved or to be dissolved, and the problem that the dissolution rate of hirudin in grinded leeches of a conventional oral leech capsule is low is solved.

Description

technical field [0001] The invention relates to the technical field of deep processing of leeches, in particular to a leech capsule. Background technique [0002] Leeches, commonly known as leeches, belong to the family Hirudidae. Leeches mainly contain the following components: ① fresh leech saliva contains various anticoagulant components, such as hirudin, hirudin-PA, heparin, antithrombotic factor, etc.; the 64 amino acid polypeptide components also have anticoagulant effect; Hirudin is the most important active substance of the drug, is a specific inhibitor of thrombin, and is a single-chain polypeptide composed of 65 or 66 amino acid residues; hirudin has three varieties, referred to as HV1, HV2, and HV3, all of which have anti Thrombin activity; ②Enzymes and enzyme inhibitors: fresh leech contains a variety of enzymes and enzyme inhibitors, such as glyceryl sphingomyelin lyase, propionylcholinesterase, lipase, cholesterol lipase, allosteric enzyme anti Trypsin active...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K9/48A61P15/00A61P29/00A61P7/02
CPCA61K35/62A61K9/48
Inventor 覃春花覃海南
Owner 广西鹿帅仁生物科技有限公司
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