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Biological tendon repair material and preparation method thereof

A repair material and biological technology, applied in tissue regeneration, medical science, prosthesis, etc., to achieve high tensile strength, avoid excessive tension, and ensure structural safety

Active Publication Date: 2021-02-02
BEIJING BIOSIS HEALING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above-mentioned technical problems, the present invention provides a biological tendon repair material, which is prepared from extracellular matrix treated with immunogen removal without delamination, and the material has a first region and a second region. A surface is not only conducive to cell infiltration of defective tissue and complete tissue repair, but also allows the stress on the repair material to be evenly distributed to avoid excessive local stress; in addition, it has a relatively high suture retention force, which can As the second surface of the suture area of ​​the repair material, it can ensure the strength of the repair material while facilitating the repair of defective tissue

Method used

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  • Biological tendon repair material and preparation method thereof
  • Biological tendon repair material and preparation method thereof
  • Biological tendon repair material and preparation method thereof

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Embodiment Construction

[0051] The present invention will be further described in detail below in conjunction with the examples, but the embodiments of the present invention are not limited thereto.

[0052] Preliminary processing of biological tissue material. The small intestine was taken and divided, and the submucosa tissue material of the small intestine was peeled off, washed and then filtered dry. When taking it, measure the filtered small intestine with a volume measuring device such as a measuring cylinder. When taking other biological tissues, the extracellular matrix must also be stripped first and preliminarily cleaned. Preliminary treatment can also include virus inactivation, for example, using a virus inactivating solution, such as peracetic acid-ethanol solution, soaking the small intestinal submucosa tissue material for virus inactivation, and this process can be carried out in a stainless steel bucket using peracetic acid-ethanol solution . Wherein, the concentration of peracetic...

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Abstract

The invention provides a biological tendon repairing material and a preparation method thereof. The biological tendon repairing material comprises an extracellular matrix body subjected to immunogen removal, wherein the extracellular matrix body consists of one or more layers and comprises a first surface and a second surface; the first surface comprises a first area and a second area; the mechanical strength of the first area is lower than that the second area. During preparation of an extracellular matrix subjected to immunogen removal, layering is avoided. As the biological tendon repairingmaterial is provided with the surface which consists of the first area and the second area, cellular infiltration of defective tissues is facilitated, tissue repairing is accomplished, stress born bythe repairing material can be uniformly distributed, and local stress cannot be excessively large. Besides, the surface has a high suture retention force and can serve as the second surface of a suture area of the repairing material, and the strength of the repairing material can be guaranteed while repairing of the defective tissues is facilitated.

Description

technical field [0001] The invention relates to a biological tendon repair material and a preparation method thereof. Specifically, it relates to an extracellular matrix bioremediation material after immunogen removal treatment. The biomaterial is suitable for tendon repair, especially for rotator cuff repair. Background technique [0002] The degradable biorepair material made of extracellular matrix is ​​a kind of good tissue repair material. The extracellular matrix is ​​made of allogeneic or heterogeneous tissues using decellularization technology to remove all components that can cause immune rejection of the host, and to obtain a completely preserved extracellular matrix and three-dimensional scaffold structure. When the extracellular matrix is ​​used to repair defective tissue, host cells grow on the extracellular matrix, secrete new extracellular matrix components, and form their own tissue, thereby completing the repair and reconstruction of the defective tissue. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/40A61L27/58
CPCA61L27/3633A61L27/3662A61L27/3691A61L27/58A61L2430/10A61L2430/40
Inventor 赵博王洪权夏磊磊赵延瑞费福垒李学军张晋辉
Owner BEIJING BIOSIS HEALING BIOLOGICAL TECH
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