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A kind of kudzu root gel ointment, its preparation method and application

A technology of multi-branch fog water kudzu and kudzu gel ointment, applied in the field of medicine, can solve the problems of poor treatment effect, small adhesive force, large adhesive force and the like

Active Publication Date: 2020-07-10
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing gel ointments have low adhesion and cannot always adhere to the skin, resulting in poor therapeutic effect; and some have too much adhesion, which makes the skin uncomfortable when removed.

Method used

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  • A kind of kudzu root gel ointment, its preparation method and application
  • A kind of kudzu root gel ointment, its preparation method and application
  • A kind of kudzu root gel ointment, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1 Preparation of Kudzu puerariae extract

[0076] 1. Petroleum ether extraction

[0077] Soak the pulverized kudzu (500g) in 8 times the amount (volume) of petroleum ether, and extract by heating and refluxing for 2 times, 1 hour each time; the filtered residue evaporates the petroleum ether to obtain petroleum ether extraction. Multi-branch fog water kudzu, spare;

[0078] In the embodiment of the present invention, except for 8 times of the amount of petroleum ether soaked in the water kudzu, other 6-10 times the amount of petroleum ether is suitable for the present invention; the petroleum ether extraction times are at least 2 times, preferably 2-3 times. In the embodiment, 2 times are used; except for 1h, other times such as 0.5-2h / time are applicable to the present invention.

[0079] 2. Ethanol extraction

[0080] Add 8 times the amount of 70% (v / v) ethanol to petroleum ether to extract respectively, and extract under reflux for 3 times, 1 hour each tim...

Embodiment 2

[0085] Example 2 Screening of types of framework materials

[0086] Mix sodium polyacrylate, carbomer 980, polyvinyl alcohol, and carboxymethyl cellulose with distilled water, respectively, to prepare three parts of 1% swelling solution; then add 0.2% cross-linking agent aluminum glycol, hydroxide The aluminum hydrates were mixed uniformly respectively; then the viscosity was measured by NDJ-8S rotational viscometer to judge the respective cross-linking speed and cross-linking degree. The measurement results are shown in Table 1.

[0087] Table 1 The average viscosity measurement results of different adhesives after adding different cross-linking agents respectively

[0088] group rotor, speed Average viscosity mPa.s 1% sodium polyacrylate 4#, 6r / min 38000 1% sodium polyacrylate + aluminum glycerol 0.4g 4#, 6r / min 21600 1% sodium polyacrylate + aluminum hydroxide 0.4g 4#, 6r / min 37600 1% Carbomer 980 2#, 6r / min 3090 1% Carbom...

Embodiment 3

[0090] Example 3 Screening of types of framework materials

[0091] Carbomer 980, sodium polyacrylate, and carbomer 980 and sodium polyacrylate were used in combination with the cross-linking agent aluminum glycerol for cross-linking, respectively, and then the viscosity was measured. The dosage and measurement results are shown in Table 2.

[0092] Table 2 Measurement results of average viscosity of carbomer 980, sodium polyacrylate, carbomer and sodium polyacrylate cross-linking with aluminum glycerol

[0093]

[0094] The measurement results in Table 2 show that the cross-linked product of carbomer and sodium polyacrylate can be used as the matrix of gel ointment. Carbomer has good water absorption and is easy to disperse in water. Under the action of trivalent aluminum ions, it can cross-link with sodium polyacrylate. The viscosity rises rapidly after joining. Compared with single use of carbomer or sodium polyacrylate, the combination of sodium polyacrylate and carbom...

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Abstract

The invention discloses a pouzolzia zeylanica var. microphylla gel ointment, a preparation method and an application thereof. The pouzolzia zeylanica var. microphylla gel ointment is prepared by a medical pouzolzia zeylanica var. microphylla extract product used for treating supurative skin infection and medical auxiliary materials, which comprises a backing layer, a medical matrix layer and a cover layer, the medical matrix layer is composed of a medical pouzolzia zeylanica var. microphylla extract product and a matrix, and the matrix comprises a frame material, a cross-linking agent, a humectant, a filler, and distilled water. The gel ointment can avoid the disadvantages that for achieving treatment effect, according to a traditional administration mode of pouzolzia zeylanica var. microphylla, plasma concentration is increased, drugs dose is large, medication time is long, medical concentration at an affected part cannot be partially increased, and stimulation and allergy can be easily generated; the pouzolzia zeylanica var. microphylla gel ointment has the advantages of large drug loading, long drug effect, little irritation on skin, usage is convenient, and drug usage compliance for patients, and provides a novel administration dosage form for clinical application of pouzolzia zeylanica var. microphylla.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine extract gel ointment and a preparation method and application thereof, in particular to a traditional Chinese medicine gel ointment for treating purulent skin infection, a preparation method and an application thereof, and belongs to the technical field of medicine. Background technique [0002] As a new type of transdermal drug delivery preparation, the composition and structural characteristics of gel ointment determine that it has some unique advantages: it is based on water-soluble polymer materials, and has less allergic irritation to the skin; It has good compatibility, affinity and air permeability, and feels comfortable when it is attached to the skin; it has a large drug load, which is suitable for the characteristics of large dosage of traditional Chinese medicine; no organic solvent is used in the production process, which meets environmental protection requirements; the dosage is accur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/32A61K36/185A61P17/02A61P31/04
CPCA61K9/7053A61K9/7061A61K36/185A61K2236/333A61K2236/39
Inventor 郭丽冰陈求芳陶曙红陈艳芬
Owner GUANGDONG PHARMA UNIV
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