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Exocarpium citri grandis produtive cough atomization inhalation solution preparation and preparation method thereof

A technology of atomized inhalation and orange-red phlegm cough, which is applied in the field of pharmaceuticals, can solve the problems of no suitable dosage form, few products, and no use of atomized inhalation preparations, and achieve the effect of easy and relatively effective treatment

Inactive Publication Date: 2018-03-13
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
The orange red phlegm cough is an oral dosage form, and there is no clinical application of aerosol inhalation preparations.
At the same time, traditional Chinese medicine has a good curative effect on bronchitis, pharyngitis, etc., but because there is no suitable dosage form, it can better exert its effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of the active ingredients of orange red phlegm cough:

[0032] 90g Huajuhong, 9g Mibaibu, 9g Poria, 9g Pinellia, 15g Baiqian, 3g Licorice, 30g Bitter Almond, 6g Schisandra

[0033] Weigh the eight herbs according to the above parts by weight, distill Huajuhong and bitter almonds with water, collect 80ml of the distillate to obtain the medicinal solution I; add water to the medicinal residues together with Mibabu, Poria cocos, Zhipinellia, Baiqian, licorice and Schisandra Decoct twice, 2 hours each time, add 8 times the amount of water for the first time, add 6 times the amount of water for the second time, combine the filtrate, let it stand, take the supernatant, filter, concentrate to an appropriate amount, let it cool, and add ethanol Make the alcohol content 75%, stir well, refrigerate for 24 hours, take the supernatant, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add ethanol to make the alcohol content 80%, st...

Embodiment 2

[0041] (1) Preparation of the active ingredients of orange red phlegm cough:

[0042] 180g Huajuhong, 18g Mibabu, 18g Poria, 18g Zhipinellia, 30g Baiqian, 6g licorice, 60g bitter almond, 12g Schisandra

[0043] Weigh the eight herbs according to the above parts by weight, distill Huajuhong and bitter almonds with water, collect 80ml of the distillate to obtain the medicinal solution I; add water to the medicinal residues together with Mibabu, Poria cocos, Zhipinellia, Baiqian, licorice and Schisandra Decoct twice, 2 hours each time, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, combine the filtrate, let it stand, take the supernatant, filter, concentrate to an appropriate amount, let it cool, and add ethanol Make the alcohol content 80%, stir well, refrigerate for 24 hours, take the supernatant, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add ethanol to make the alcohol content...

Embodiment 3

[0051] (1) Preparation of the active ingredients of orange red phlegm cough:

[0052] 270g of Huajuhong, 27g of Mibaibu, 27g of Poria, 27g of Zhipinellia, 45g of Baiqian, 9g of Licorice, 90g of Bitter Almond, 18g of Schisandra

[0053] Weigh the eight herbs according to the above parts by weight, distill Huajuhong and bitter almonds with water, collect 80ml of the distillate to obtain the medicinal solution I; add water to the medicinal residues together with Mibabu, Poria cocos, Zhipinellia, Baiqian, licorice and Schisandra Decoct twice, 2 hours each time, add 12 times the amount of water for the first time, add 10 times the amount of water for the second time, combine the filtrate, let it stand, take the supernatant, filter, concentrate to an appropriate amount, let it cool, and add ethanol Make the alcohol content 85%, stir well, refrigerate for 24 hours, take the supernatant, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add ethanol t...

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PUM

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Abstract

The invention relates to an exocarpium citri grandis produtive cough atomization inhalation solution preparation, and belongs to the field of pharmaceutical pharmacy, wherein the exocarpium citri grandis produtive cough atomization inhalation solution preparation comprises (1) an exocarpium citri grandis produtive cough effective component, and (2) an isotonic agent and a solvent. According to thepresent invention, the prepared exocarpium citri grandis produtive cough atomization inhalation solution preparation makes up for the gap in the current domestic market, and is specifically designedfor atomization inhalation patients, wherein the exocarpium citri grandis produtive cough atomization inhalation solution preparation is directly inhaled into the respiratory system in an atomized form after the exocarpium citri grandis produtive cough atomization inhalation solution preparation is atomized by an ultrasonic atomizer or an air compression type atomizer, such that the use is convenient; and compared to the exocarpium citri grandis produtive cough liquid, the exocarpium citri grandis produtive cough atomization inhalation solution preparation of the present invention has the different administration route, has advantages of use dose reducing, rapid effect and improved safety, can well treat cough, asthma and excessive phlegm caused by phlegm stagnating lung, common cold, bronchitis and pharyngitis, and can provide other effects.

Description

technical field [0001] The invention relates to a solution preparation for atomized inhalation of orange-red phlegm cough and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] The prescription of Juhong Tanke preparation is evolved on the basis of the classic prescription "Erchen Decoction" in ancient my country. The medication is exquisite and the curative effect is remarkable. Its main ingredient is naringin, which has the effects of regulating qi and resolving phlegm, moistening the lungs and relieving cough. It is used for the treatment of cough, asthma, excessive phlegm caused by turbid phlegm blocking the lung, as well as colds, bronchitis, and pharyngitis. At present, the orange red phlegm and cough series preparations sold in the market include oral liquid, decoction, granules, effervescent tablets, etc. Among them, the orange red phlegm and cough liquid and decoction were already on the market in 1985. After years of cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/72A61K9/08A61K47/69A61P11/14A61P11/10
CPCA61K36/752A61K9/0078A61K9/08A61K36/076A61K36/27A61K36/484A61K36/57A61K36/736A61K36/79A61K36/8888A61K36/904A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 张保献李艳英
Owner BEIJING INCREASEPHARM CORP LTD
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