Children lung-clearing phlegm-eliminating solution preparation for atomization inhalation and preparation method of children lung-clearing phlegm-eliminating solution

A technology for clearing the lungs, removing phlegm, and atomizing inhalation, applied in the field of formulations, can solve the problems of few products, no dosage forms, and no use of atomized inhalation preparations, and achieves reduced dosage, improved safety, and increased compliance. Effect

Inactive Publication Date: 2018-03-09
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
However, Qingfei Huatan is an oral dosage form for children, and there is no clinical application of nebulized inhalation preparations.
At the same time, traditional Chinese medicine has a good effect on cough caused by wind-heat invading the lungs in children, but because there is no suitable dosage form, it can better exert its effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of active ingredients for clearing lung and resolving phlegm in children:

[0031] Ephedra 27g, Peucedanum 67.5g, Scutellaria baicalensis 67.5g, fried perilla seeds 67.5g, gypsum 202.5g, fried bitter almonds 67.5g, Tinglizi 83.7g, Zhuru 67.5g

[0032] Gypsum plus 8 times the amount of prescription medicinal materials, decocted in water for 1 hour, then added ephedra and other remaining Qiwei medicinal materials, among which Tinglizi was decocted, decocted twice, each time for 1 hour, filtered, the filtrates were combined, concentrated to a clear paste, and concentrated Add ethanol to the liquid to make the alcohol concentration reach 70%, shake well, refrigerate, filter, and recover the ethanol to an appropriate amount from the filtrate; add ethanol again to make the alcohol concentration reach 80%, stir well, refrigerate, filter, add activated carbon to the filtrate for adsorption, and store at room temperature Stir, filter, recover ethanol until there ...

Embodiment 2

[0040] (1) Preparation of active ingredients for clearing lung and resolving phlegm in children:

[0041] Ephedra 54g, Peucedanum 135g, Scutellaria baicalensis 135g, fried perilla seeds 135g, gypsum 405g, fried bitter almonds 135g, Tinglizi 167.4g, Zhuru 135g

[0042] Gypsum plus 8 times the amount of prescription medicinal materials, decocted in water for 1 hour, then added ephedra and other remaining Qiwei medicinal materials, among which Tinglizi was decocted, decocted twice, each time for 1 hour, filtered, the filtrates were combined, concentrated to a clear paste, and concentrated Add ethanol to the liquid to make the alcohol concentration reach 70%, shake well, refrigerate, filter, and recover the ethanol to an appropriate amount from the filtrate; add ethanol again to make the alcohol concentration reach 85%, stir well, refrigerate, filter, add activated carbon to the filtrate, and stir at room temperature , filter, recover ethanol until there is no alcohol smell, add w...

Embodiment 3

[0050] (1) Preparation of active ingredients for clearing lung and resolving phlegm in children:

[0051] Ephedra 81g, Peucedanum 202.5g, Scutellaria baicalensis 202.5g, fried perilla seed 202.5g, gypsum 607.5g, fried bitter almond 202.5g, Tinglizi 251.1g, Zhuru 202.5g

[0052] Gypsum plus 8 times the amount of prescription medicinal materials, decocted in water for 1 hour, then added ephedra and other remaining Qiwei medicinal materials, among which Tinglizi was decocted, decocted twice, each time for 1 hour, filtered, the filtrates were combined, concentrated to a clear paste, and concentrated Add ethanol to the liquid to make the alcohol concentration reach 70%, shake well, refrigerate, filter, and recover the ethanol to an appropriate amount from the filtrate; add ethanol again to make the alcohol concentration reach 90%, stir well, refrigerate, filter, add activated carbon to the filtrate, and stir at room temperature , filter, recover ethanol until there is no alcohol sm...

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PUM

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Abstract

The invention relates to a children lung-clearing phlegm-eliminating solution preparation for the atomization inhalation, which belongs to the field of science of preparation. The children lung-clearing phlegm-eliminating solution preparation is prepared from (1) children lung-clearing phlegm-eliminating active ingredients; and (2) an isotonic agent and a solvent. The solution preparation preparedby the invention fills the gap of the domestic market at present; and moreover, the solution preparation prepared by the invention is designed particularly for an atomization inhalation patient; theprepared atomization inhalation solution preparation is atomized by virtue of an ultrasonic atomizer or an air compression-type atomizer and is directly inhaled into a respiratory system in a mist form, the use process is convenient, compared with children lung-clearing phlegm-eliminating oral liquid, an administration route is different, the use dosage is reduced, the solution preparation can take effect quickly, the safety is improved, and an effect for treating cough caused by the wind-heat affecting lung can be better played.

Description

technical field [0001] The invention relates to a solution preparation for clearing the lungs and resolving phlegm in children by atomization inhalation and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Clearing the lungs and resolving phlegm in children is a classic prescription. In the prescription, ephedra and Qianhu are the king medicines. Ephedrine hydrochloride and pseudoephedrine hydrochloride are the main active ingredients of ephedra. Baicalin is the main active ingredient of Scutellaria baicalensis, amygdalin is the main active ingredient of bitter almond, clearing away heat and resolving phlegm in children, relieving cough and relieving asthma . It is used for cough caused by wind-heat invading the lung in children. Symptoms include shortness of breath, coughing with phlegm and wheezing, and scratching in the throat. The existing Qingfei Huatan Oral Liquid for Children has a good effect, a high cure rate, and hig...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/72A61K9/08A61K47/02A61K47/26A61P11/00A61P11/10A61K33/06
CPCA61K9/0078A61K9/08A61K33/06A61K36/17A61K36/23A61K36/31A61K36/535A61K36/539A61K36/736A61K36/899A61K47/02A61K47/26A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张保献李艳英
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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