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Solution preparation for atomization inhalation of children Kechuanling and preparation method of solution preparation

A technology for atomized inhalation and infantile cough and asthma, applied in the field of pharmacy, can solve the problems of no suitable dosage form, few products, and no use of atomized inhalation preparations, so as to increase compliance, reduce dosage, and improve safety Effect

Inactive Publication Date: 2018-03-09
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
However, Kechuanling for children is an oral dosage form, and there is no clinical application of nebulized inhalation preparations.
At the same time, traditional Chinese medicine has a good effect on upper respiratory tract infection, bronchitis, pneumonia, etc., but because there is no suitable dosage form, it can better exert its effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of active ingredients of Kechuanling for children:

[0032] Ephedra 3.75g, honeysuckle 37.5g, bitter almond 18.75g, isatis root 37.5g, gypsum 56.25g, licorice 18.75g, melon wilt 18.75g

[0033] Weigh the Qiwei medicine according to the above weight parts, add bitter almond, gypsum, isatis root, licorice, melon wilt, add 8 times the amount of water to decoct for 1 hour, filter; Combine the filtrates, let stand, take the supernatant, concentrate to an appropriate amount, add ethanol to make the alcohol content 70%, stir well, let stand, refrigerate for 12 hours, take the supernatant, filter, and recover the ethanol from the filtrate until it has no alcohol smell, Add ethanol again to make the alcohol content to 75%, stir well, let it stand, refrigerate for 12 hours, take the supernatant, filter, recover the ethanol from the filtrate until it has no alcohol smell, add an appropriate amount of water for injection, stir well, refrigerate for 24 hours, take th...

Embodiment 2

[0041] (1) Preparation of active ingredients of Kechuanling for children:

[0042] Ephedra 6.25g, honeysuckle 62.5g, bitter almond 31.25g, isatis root 62.5g, gypsum 93.75g, licorice 31.25g, melon wilt 31.25g

[0043] Weigh the seven herbs according to the above parts by weight, add bitter almonds, gypsum, isatis root, licorice, and melon wilt, add 10 times the amount of water to decoct for 1 hour, filter; Combine the filtrates, let stand, take the supernatant, concentrate to an appropriate amount, add ethanol to make the alcohol content 75%, stir well, let stand, refrigerate for 12 hours, take the supernatant, filter, and recover the ethanol from the filtrate until it has no alcohol smell, Add ethanol again to make the alcohol content 85%, stir well, let it stand, refrigerate for 12 hours, take the supernatant, filter, recover the ethanol from the filtrate until it has no alcohol smell, add an appropriate amount of water for injection, stir well, refrigerate for 36 hours, take...

Embodiment 3

[0051] (1) Preparation of active ingredients of Kechuanling for children:

[0052] Ephedra 2.5g, honeysuckle 25g, bitter almond 12.5g, Radix Radix 25g, gypsum 37.5g, licorice 12.5g, melon wilt 12.5g

[0053] Weigh the seven herbs according to the above parts by weight, add bitter almonds, gypsum, isatis root, licorice, and melon wilt, add 12 times the amount of water to decoct for 1 hour, filter; Combine the filtrate, let it stand still, take the supernatant, concentrate to an appropriate amount, add ethanol to make the alcohol content 80%, stir well, let it stand, refrigerate for 12 hours, take the supernatant, filter, and recover the ethanol from the filtrate until it has no alcohol smell, Add ethanol again to make the alcohol content 85%, stir well, let it stand, refrigerate for 12 hours, take the supernatant, filter, recover the ethanol from the filtrate until it has no alcohol smell, add an appropriate amount of water for injection, stir well, refrigerate for 48 hours, ta...

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Abstract

The invention relates to a solution preparation for the atomization inhalation of the children Kechuanling, which belongs to the field of science of preparation. The solution preparation for the atomization inhalation of the children Kechuanling is prepared from (1) children Kechuanling active ingredients; and (2) an isotonic agent and a solvent. The solution preparation prepared by the inventionfills the gap of the domestic market at present; and moreover, the solution preparation prepared by the invention is designed particularly for an atomization inhalation patient; the prepared atomization inhalation solution preparation is atomized by virtue of an ultrasonic atomizer or an air compression-type atomizer and is directly inhaled into a respiratory system in a mist form, the use processis convenient, compared with children Kechuanling oral liquid, an administration route is different, the use dosage is reduced, the solution preparation can take effect quickly, the safety is improved, and an effect for treating the upper respiratory infection, trachitis, lung, cough and the like can be better played.

Description

technical field [0001] The invention relates to a solution preparation for nebulization and inhalation of Kechuanling for children and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Pediatric Kechuanling is a classic Chinese patent medicine. Its main ingredients are ephedrine and chlorogenic acid. For the treatment of upper respiratory tract infection, bronchitis, pneumonia, cough and other diseases. The existing Kechuanling preparations for children include granules, tablets, oral liquids and the like. Because of its clear curative effect, it is welcomed by both doctors and patients. It is a typical representative of traditional Chinese medicine for Xuanfei and heat clearing. [0003] The traditional oral dosage form has a large dosage and cannot directly act on the affected part. It needs to act on the affected part through the first-pass effect of the liver, which has a slow onset of action and increases the distribution ...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K9/72A61K47/02A61K47/26A61P11/00A61P31/00A61P11/14A61K33/06
CPCA61K9/0043A61K9/0078A61K9/08A61K33/06A61K36/17A61K36/195A61K36/315A61K36/355A61K36/428A61K36/484A61K36/736A61K47/02A61K47/26A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张保献李艳英
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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