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Trollius chinensis solution preparation for aerosol inhalation and preparation method thereof

A technology of atomized inhalation and nasturtium, applied in the field of pharmaceuticals, can solve the problems of no suitable dosage form, few products, and no use of atomized inhalation preparations, etc., and achieve the effect of easy and comparative therapeutic effect

Pending Publication Date: 2021-08-06
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
And Trollius is an oral dosage form, and there is no clinical application of nebulized inhalation preparations.
At the same time, traditional Chinese medicine has a good effect on upper respiratory tract infection, tonsillitis, pharyngitis, etc., but because there is no suitable dosage form, it can better exert its effect

Method used

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  • Trollius chinensis solution preparation for aerosol inhalation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of active ingredients of Trollus chinensis:

[0032] Add 90g of nasturtium herb, add 10 times the amount of water, decoct 3 times, 1.5h each time, combine the filtrate, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol concentration reach 45%, refrigerate the alcohol precipitation liquid for 36h, take it up Clear liquid, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add appropriate amount of water and stir evenly, boil and refrigerate for 24 hours, take the supernatant and concentrate to an appropriate amount, add ethanol again to make the alcohol concentration reach 75%. Refrigerate for 36 hours, take the supernatant, put it at room temperature, add activated carbon to stir and absorb for 30 minutes, filter, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add an appropriate amount of water and mix well, boil and refrigerate for 24 hours, t...

Embodiment 2

[0040] (1) Preparation of active ingredients of Trollus chinensis:

[0041] Add 225g of nasturtium herb, add 12 times the amount of water, decoct 3 times, 1.5h each time, combine the filtrate, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol concentration reach 50%, refrigerate the alcohol precipitation liquid for 36h, take it up For the supernatant, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add an appropriate amount of water, stir evenly, boil and refrigerate for 24 hours, take the supernatant and concentrate to an appropriate amount, add ethanol again to make the alcohol concentration reach 80%. Refrigerate for 36 hours, take the supernatant, put it at room temperature, add activated carbon to stir and absorb for 30 minutes, filter, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add an appropriate amount of water and mix well, boil and refrigerate for 36 ...

Embodiment 3

[0049] (1) Preparation of active ingredients of Trollus chinensis:

[0050] Add 315g of nasturtium herb, add 15 times the amount of water, decoct 3 times, 1.5h each time, combine the filtrate, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the alcohol concentration reach 55%, refrigerate the alcohol precipitation liquid for 36h, take it up For the supernatant, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add an appropriate amount of water, stir evenly, boil and refrigerate for 24 hours, take the supernatant and concentrate to an appropriate amount, add ethanol again to make the alcohol concentration reach 85%. Refrigerate for 36 hours, take the supernatant, put it at room temperature, add activated carbon to stir and absorb for 30 minutes, filter, recover ethanol until it has no alcohol smell, concentrate to an appropriate amount, add an appropriate amount of water and mix well, boil and refrigerate for 36 ...

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Abstract

The invention relates to a trollius chinensis solution preparation for aerosol inhalation, and belongs to the field of pharmaceutics. The solution preparation for aerosol inhalation with heat-clearing and cough-relieving functions in children comprises (1) active ingredients of trollius chinensis; and (2) an isotonic agent and a solvent. The solution preparation of the present invention fills the gaps in the domestic market at present. The solution preparation of the present invention is designed for aerosol inhalation in patients. The solution preparation for aerosol inhalation is directly inhaled into the respiratory system in the form of atomization after being atomized by an ultrasonic atomizer or an air compression type atomizer, so that the solution preparation is convenient in use. Compared with trollius chinensis oral liquid, the trollius chinensis solution preparation has different administration routes, lower dosage, quick response and higher safety, and can play a better role in treating upper respiratory infection, acute tonsillitis, pharyngitis, etc.

Description

[0001] This invention is a divisional application of the Chinese invention patent application with the application number 201610759643.3 and the application date on August 30, 2016, and the invention title is "a solution preparation for nebulis inhalation of nasturtium and its preparation method". Incorporated herein by reference. technical field [0002] The invention relates to a solution preparation for atomized inhalation of nasturtium lotus and a preparation method thereof, belonging to the field of pharmacy. Background technique [0003] Trollius is the dried flower of Trollius chinensis Bunge (Trollius chinensis Bunge), a plant of the Ranunculaceae family. "Compendium of Materia Medica Supplements" states that it is "bitter in taste, cold in nature, and non-toxic", and can "cure mouth sores, swollen throat, feverish teeth, ear pain, eye pain, improve eyesight, and relieve miasma." There are 25 species of Trollaceae plants, distributed in the northern temperate zone a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/12A61K36/71A61P11/00A61P11/04A61K133/00
CPCA61K9/0078A61K9/12A61K36/71A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P11/00A61P11/04
Inventor 张保献李艳英
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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