Cough and asthma relieving solution preparation for aerosol inhalation and preparation method of cough and asthma relieving solution preparation

A technology for atomization inhalation and Kechuanning, which is applied in the field of formulations, can solve the problems of no suitable dosage form, few products, and no use of atomized inhalation preparations, and achieves the effects of comparative treatment effect and easy treatment effect.

Pending Publication Date: 2021-08-13
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are relatively few products on the market for nebulized inhalation solution preparations, mainly imported products
Kechuanning is an oral dosage form, and there is no clinical application of nebulized inhalation preparations.
At the same time, traditional Chinese medicine has a good curative effect on upper respiratory tract infection, but there is no suitable dosage form to make it more effective.

Method used

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  • Cough and asthma relieving solution preparation for aerosol inhalation and preparation method of cough and asthma relieving solution preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of the active ingredient of Kechuanning:

[0031] 26.8g ephedra, 13.4g gypsum, 26.6g bitter almond, 13.4g platycodon, 13.4g centipede, 13.4g poppy shell, 26.6g licorice

[0032] The above seven flavors and gypsum are crushed into fine powder, decocted with water for 1 hour, filtered, and the filtrate is used for later use; the dregs and other six flavors such as ephedra are decocted twice, and the pH value is adjusted to 5.0 with hydrochloric acid after adding water each time, 1.5 hours each time, Filtrate, combine the filtrates, add the above standby medicinal liquid, concentrate to a clear paste, let it cool, add ethanol to make the alcohol content reach 70%, refrigerate and stand for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 3 times the amount Add water, adjust the pH to 5.0, heat to boil, refrigerate, stand still for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to ma...

Embodiment 2

[0040] (1) Preparation of the active ingredient of Kechuanning:

[0041] 67g ephedra, 33.5g gypsum, 66.5g bitter almond, 33.5g platycodon, 33.5g centipede, 33.5g poppy shell, 66.5g licorice

[0042] The above seven flavors and gypsum are crushed into fine powder, decocted with water for 1 hour, filtered, and the filtrate is used for later use; the dregs and other six flavors such as ephedra are decocted twice, and the pH value is adjusted to 5.0 with hydrochloric acid after adding water each time, 1.5 hours each time, Filtrate, combine the filtrates, add the above standby medicinal liquid, concentrate to a clear paste, let it cool, add ethanol to make the alcohol content reach 75%, refrigerate and stand for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 4 times the amount Add water, adjust the pH to 5.0, heat to boil, refrigerate, stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the a...

Embodiment 3

[0050] (1) Preparation of the active ingredient of Kechuanning:

[0051] Ephedra 53.6g, Gypsum 26.8g, Bitter Almond 53.2g, Campanulaceae 26.8g, Baibu 26.8g, Poppy Shell 26.8g, Licorice 53.2g

[0052] The above seven flavors and gypsum are crushed into fine powder, decocted with water for 1 hour, filtered, and the filtrate is used for later use; the dregs and other six flavors such as ephedra are decocted twice, and the pH value is adjusted to 5.0 with hydrochloric acid after adding water each time, 1.5 hours each time, Filtrate, combine the filtrates, add the above standby medicinal liquid, concentrate to a clear paste, let it cool, add ethanol to make the alcohol content reach 75%, refrigerate and stand for 48 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add 2 times the amount Add water, adjust the pH to 7.0, heat to boil, refrigerate, stand for 48 hours, filter, concentrate the filtrate to an appropriate amount, add ethanol to make the ...

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Abstract

The invention relates to a cough and asthma relieving solution preparation for aerosol inhalation, and belongs to the field of pharmaceutics. The cough and asthma relieving solution preparation comprises (1) a cough and asthma relieving effective component; and (2) an isotonic agent and a solvent. According to the present invention, the prepared solution preparation makes up the blank in the domestic market at present, the prepared solution preparation is specially designed for patients for aerosol inhalation, the prepared solution preparation for aerosol inhalation is directly inhaled into the respiratory system in an atomized form after being atomized by an ultrasonic atomizer or an air compression type atomizer, and the use process is convenient and fast. Compared with cough and asthma relieving oral liquid, the cough and asthmarelieving solution preparation for aerosol inhalation is different in administration route, small in dosage, quick in effect taking, high in safety and capable of better playing a role in treating chronic cough, and asthma caused by excessive phlegm.

Description

technical field [0001] The invention relates to a solution preparation for nebulized inhalation of Kechuanning and a preparation method thereof, belonging to the field of pharmacy. Background technique [0002] Kechuanning is a classic Chinese patent medicine. Its main ingredients are ephedra, gypsum, bitter almond, platycodon grandiflorum, basil, poppy shell, licorice, etc. It has the effect of dredging lung qi, relieving cough and relieving asthma. For chronic cough, phlegm wheezing with phlegm-heat syndrome, symptoms include frequent cough, yellow phlegm, shortness of breath and chest tightness. Existing Kechuanning preparations include tablets, capsules, oral liquids and the like. Because of its clear curative effect and long history of medication, it is a typical representative of traditional Chinese medicine for Xuanfei Qingre. [0003] The traditional oral dosage form has a large dosage and cannot directly act on the patient site. It needs to enter the circulatory s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K9/72A61K9/08A61K47/02A61K47/26A61K47/10A61P11/14A61P11/00A61P11/06A61P11/10
CPCA61K9/0078A61K9/08A61K33/06A61K36/17A61K36/346A61K36/484A61K36/66A61K36/736A61K36/904A61K47/02A61K47/10A61K47/26A61P11/00A61P11/06A61P11/10A61P11/14A61K2300/00
Inventor 张保献李艳英
Owner BEIJING INCREASEPHARM CORP LTD
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