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Cellulose-based sustained release type fat-soluble vitamin tablet and preparation method thereof

A fat-soluble vitamin, based slow-release technology, applied in the field of cellulose-based slow-release fat-soluble vitamin tablets and its preparation, can solve the problems of fat-soluble vitamins such as poor solubility, low bioavailability, and frequent taking, and achieve biological Degradation is easy to modify, good biocompatibility, and fast biodegradation

Inactive Publication Date: 2018-03-02
刘滨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a cellulose-based slow-release fat-soluble vitamin for the problems of poor solubility, poor stability, low bioavailability, frequent consumption, and inconvenience to users. Tablet and its preparation method

Method used

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  • Cellulose-based sustained release type fat-soluble vitamin tablet and preparation method thereof

Examples

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Effect test

example 1

[0019] Take 100g of cellulose, add 400mL of 10% sodium hydroxide solution, stir at 30°C for 20min at 300r / min, then add 10g of hexadecane bromide, keep it warm for 3h, cool to room temperature and filter to obtain the filter residue , wash the filter residue with deionized water until the washing liquid is neutral, then transfer it to a drying oven, and dry it to constant weight at 105°C to obtain hexadecyloxycellulose. Take 50g of hexadecyloxycellulose, 20g Ethyl cellulose and 10g of lactose were put into a grinder and ground, passed through a 100-mesh sieve to obtain a composite powder. Take 1g of the composite powder, add 4g of the compound powder to a 50% ethanol solution, stir at 200r / min for 30min, and then Add 100mg of fat-soluble vitamins, mix evenly, place in a drying oven, dry at 50°C for 1 hour, then put into a kneader to granulate, pass through a 24-mesh sieve for granulation, and then mix with 0.1g magnesium stearate evenly Put it in a tablet machine, and press it...

example 2

[0021] Take 150g of cellulose, add it to 600mL of 10% sodium hydroxide solution, stir at 32°C at 350r / min for 25min, then add 15g of hexadecane bromide, keep it warm for 4h, cool to room temperature and filter to obtain the filter residue , wash the filter residue with deionized water until the washing liquid is neutral, then transfer it to a drying oven, and dry it to a constant weight at 107°C to obtain hexadecyloxycellulose. Take 55g of hexadecyloxycellulose, 25g Ethyl cellulose and 20g lactose were put into a grinder and ground, and passed through a 100-mesh sieve to obtain a composite powder. Take 1g of the composite powder, add 6g of the composite powder to a 63% ethanol solution, stir at 250r / min for 35min, and then Add 150mg of fat-soluble vitamins, mix evenly, place in a drying oven, dry at 55°C for 2 hours, then put into a kneader to granulate, pass through a 24-mesh sieve for granulation, and then mix with 0.15g magnesium stearate evenly Put it in a tablet machine, ...

example 3

[0023] Take 200g of cellulose, add 800mL of 10% sodium hydroxide solution, stir at 35°C at 400r / min for 30min, then add 20g of hexadecane bromide, keep it warm for 5h, cool to room temperature and filter to obtain the filter residue , wash the filter residue with deionized water until the washing liquid is neutral, then transfer it to a drying oven, and dry it to constant weight at 110°C to obtain hexadecyloxycellulose. Take 60g of hexadecyloxycellulose, 30g Ethyl cellulose, 30g lactose, grind in grinder, cross 100 mesh sieves, get composite powder, get 2g composite powder, add 8g mass fraction and be in 75% ethanol solution, stir 40min with 300r / min, then Add 200mg of fat-soluble vitamins, mix evenly, place in a drying oven, dry at 60°C for 3 hours, then put into a kneader to granulate, pass through a 24-mesh sieve for granulation, and then mix with 0.2g magnesium stearate evenly Put it in a tablet machine, and press it into tablets to obtain cellulose-based slow-release fat-...

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Abstract

The invention relates to a cellulose-based sustained release type fat-soluble vitamin tablet and a preparation method thereof, and belongs to the technical field of food healthcare. Natural plant celluloses are used to prepare an amphiphilic cellulose micelle capable of spontaneously forming a shell-core structure in an aqueous system, the amphiphilic cellulose micelle has a good stability, can greatly improve the dispersibility or solubility of hydrophobic substances in the aqueous system, and has certain sustained release and targeting delivery functions, and hexadecyloxy cellulose which gradually absorbs water to form a drug release skeleton, ethyl cellulose which meets water to form a retardant layer and lactose which is rapidly dissolved to form drug release small holes in the sustained release system interact with each other to control the release of vitamins in order to achieve the purposes of sustained release and targeted taking of fat-soluble vitamins, and nutrition and foodenhancement.

Description

technical field [0001] The invention relates to a cellulose-based sustained-release fat-soluble vitamin tablet and a preparation method thereof, belonging to the technical field of food health care. Background technique [0002] Vitamins are a type of trace organic substances that humans and animals must obtain from food to maintain normal physiological functions, and play an important role in the growth, metabolism, and development of the human body. Vitamins are a huge family. There are dozens of known vitamins, which can be roughly divided into two categories: fat-soluble and water-soluble. Fat-soluble vitamins mainly include VA, VD, VE and VK. VA and VD are mainly stored in the liver, VE is mainly stored in the adipose tissue in the body, and VK is stored less. They are trace nutrients needed by the human body and play a very important role in the physiological activities of the human body. [0003] Food nutritional fortifiers are natural or synthetic nutrients and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L29/30
CPCA23L29/30A23L33/15A23V2002/00A23V2250/612A23V2250/70
Inventor 刘滨王之霖史玉兰
Owner 刘滨
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