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Biological cellulose skin repair material and preparation method thereof

A biological cellulose and skin repair technology, applied in the field of medical materials, can solve the problems of complex preparation process and difficult control of the structure of the material itself, achieve good biocompatibility, promote adhesion and proliferation speed, and the preparation method is simple and easy Effect

Pending Publication Date: 2018-02-27
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problems in the prior art that the preparation process of biocellulose skin repair materials is complicated and the structure of the material itself is difficult to control, and to provide a biocellulose skin repair material that is easy to prepare and easy to regulate the structure of the material itself and its Preparation

Method used

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  • Biological cellulose skin repair material and preparation method thereof
  • Biological cellulose skin repair material and preparation method thereof
  • Biological cellulose skin repair material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] A preparation method of biocellulose skin repair material, the specific steps are as follows:

[0050] (1) prepare bacterial strain culture fluid;

[0051] The different components are mixed evenly to obtain the strain culture solution, wherein the content of glucose in the strain culture solution is 2wt%, the content of peptone is 0.3wt%, the content of yeast extract is 0.5wt%, and the content of citric acid is 0.05wt%. The content of disodium hydrogen phosphate is 0.02wt%, the content of potassium dihydrogen phosphate is 0.1wt%, and the balance is water;

[0052] (2) preparation of culture emulsion and bacterial liquid;

[0053] After carrying out homogeneous emulsification of 50 parts by weight of strain culture solution, 6 parts of peanut oil, 15 parts of polysorbate and 5 parts of gelatin, medical oxygen is passed into the emulsion at a speed of 0.1L / min, and maintained In 30 minutes, the culture emulsion with a pH value of 5 was obtained;

[0054] The refrigera...

Embodiment 2

[0062] A preparation method of biocellulose skin repair material, the specific steps are as follows:

[0063] (1) prepare bacterial strain culture fluid;

[0064] The different components are mixed evenly to obtain the strain culture solution, wherein the content of glucose in the strain culture solution is 3wt%, the content of peptone is 0.10wt%, the content of yeast extract is 0.05wt%, and the content of citric acid is 0.09wt%. The content of disodium hydrogen phosphate is 0.05wt%, the content of potassium dihydrogen phosphate is 0.01wt%, and the balance is water;

[0065] (2) preparation of culture emulsion and bacterial liquid;

[0066] After carrying out homogeneous emulsification of 52 parts by weight of strain culture solution, 5 parts of coconut oil, 3 parts of sucrose fatty acid ester and 22 parts of sodium alginate, medical air is passed into the emulsion at a speed of 1L / min , and maintained for 30 minutes to obtain a cultured emulsion with a pH value of 7;

[00...

Embodiment 3

[0075] A preparation method of biocellulose skin repair material, the specific steps are as follows:

[0076] (1) prepare bacterial strain culture fluid;

[0077] The different components are mixed evenly to obtain the strain culture solution, wherein the content of glucose in the strain culture solution is 4wt%, the content of peptone is 0.4wt%, the content of yeast extract is 0.15wt%, and the content of citric acid is 0.1wt%. The content of disodium hydrogen phosphate is 0.02wt%, the content of potassium dihydrogen phosphate is 0.08wt%, and the balance is water;

[0078] (2) preparation of culture emulsion and bacterial liquid;

[0079] After carrying out homogeneous emulsification of 56 parts by weight of strain culture solution, 9 parts of soybean oil, 5 parts of hydrogenated lecithin and 21 parts of chitosan, medical oxygen is passed into the emulsion at a speed of 0.2L / min , and maintained for 30 minutes to obtain a cultured emulsion with a pH value of 5;

[0080] Tha...

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Abstract

The invention relates to a biological cellulose skin repair material and a preparation method thereof. The preparation method is characterized in that a bacterial solution is added in a culture emulsion, is uniformly dispersed and is then subjected to static culture to obtain the biological cellulose skin repair material, wherein the bacterial solution is a system by which a bacterial strain is dispersed in water; the culture emulsion is an oil-in-water emulsion; an aqueous phase is a bacterial strain culture solution; the bacterial strain means a microorganism capable of biologically synthesizing cellulose nano fibers. The biological cellulose skin repair material and the preparation method thereof provided by the invention have the benefits that the preparation method is simple and easyto implement, convenient to operate and low in cost; the self structure of the material in the preparation process is easily regulated and controlled; the biological cellulose skin repair material prepared finally has the advantages of being good in biocompatibility, excellent in mechanical property and optimal in water-absorbing capacity and water holding capacity; the moisture volatilization canbe reduced, a wet state is kept, external bacteria is effectively blocked, the adhesion and the proliferation rate of cells are promoted, the cells are guided into the interior of the material, and the vascularization of surrounding tissues is accelerated; therefore, the skin wound repair is significantly accelerated.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a biological cellulose skin repair material and a preparation method thereof. Background technique [0002] Injury to the skin is one of the oldest and most common ailments faced by clinicians. Currently, the most clinically used artificial skin substitute is autologous epidermis, but autologous sources are limited and easily cause secondary damage. Therefore, skin repair materials that can simulate the structure of natural skin tissue are currently a hot topic in the research of skin tissue repair. [0003] Biocellulose (also known as bacterial cellulose, Baterial Cellulose BC) is a kind of exopolysaccharide secreted in vitro by microorganisms under mild conditions by metabolizing sugar sources, and is a form of cellulose in nature. Biocellulose has good biocompatibility, high tensile strength and elastic modulus, and good air permeability, water absorption and wat...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/20A61L27/56A61L27/60B82Y40/00B82Y5/00B82Y30/00A61L15/28A61L15/42
CPCA61L15/28A61L15/425A61L27/20A61L27/56A61L27/60B82Y5/00B82Y30/00B82Y40/00A61L2400/12C08L1/02
Inventor 李喆
Owner JIAXING UNIV
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