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Hemostatic material as well as preparation method and application thereof

A hemostatic material, a technology in any direction, applied in application, medical science, surgery and other directions, can solve the problems of wasting rescue hemostasis time, poor adhesion of hemostatic powder, complicated preparation process, etc., to improve hemostasis effect and improve effective coagulation factor. The effect of concentration, rapid degradation and absorption

Active Publication Date: 2018-02-27
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current hemostatic powder has problems such as poor adhesion, relatively dense, complicated preparation process, etc., and it needs to be prepared in advance, which wastes a lot of time for rescue and hemostasis

Method used

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  • Hemostatic material as well as preparation method and application thereof
  • Hemostatic material as well as preparation method and application thereof
  • Hemostatic material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0046] The first embodiment of the present invention provides a hemostatic material. The hemostatic material includes nanofiber clusters, and the nanofiber clusters have an interlaced structure formed by overlapping short nanofibers; the nanofiber clusters are derived from cross-linked nanofiber materials.

[0047] Wherein, the crosslinked nanofiber material can be obtained by performing crosslinking modification on the nanofiber material.

[0048] The hemostatic material can be obtained by shearing the cross-linked nanofibrous material. Short nanofibers can be formed at the same time after shearing, so that the nanofiber cluster has an interlaced structure formed by a plurality of short nanofibers overlapped with each other.

[0049] The hemostatic material provided in this embodiment is macroscopically powdery or granular, and can be applied to wounds by spraying or sprinkling, and is especially suitable for lacunar wounds or small wounds.

[0050]

[0051]The nanofibrou...

no. 2 approach

[0069] The second embodiment of the present invention provides a method for preparing a hemostatic material, comprising the following steps:

[0070] Electrospinning step: preparing the nanofiber material by electrospinning;

[0071] Crosslinking step: performing crosslinking treatment on the nanofiber material in the presence of a crosslinking agent to obtain a crosslinked nanofiber material;

[0072] Shearing step: performing shearing treatment on the cross-linked nanofibrous material;

[0073] Sieving step: sieving the formed body.

[0074] The "cross-linking" and "cross-linking modification" described herein have the same or similar meanings, and in the process of "cross-linking", some characteristics of "modification" can be attached. For the sake of simplicity, in the present invention, Use "cross-linked" instead of "cross-linked modification".

[0075]

[0076] In the electrospinning step, the fiber raw material is prepared in advance, and the fiber raw material is...

no. 3 approach

[0105] The third embodiment of the present invention also provides a hemostatic product, including: the hemostatic material according to the first embodiment of the present invention, or the hemostatic material prepared by the method for preparing the hemostatic material according to the second embodiment of the present invention.

[0106] The hemostatic product of the present invention can be used for hemostasis and repair when tissue oozes, capillary hemorrhage, arteriole hemorrhage, and lacunar ooze, and / or, for hemostasis and repair of burns, wounds, and surgical wounds. application prospects. In the case of hemostasis and repair when the cavity is oozing, it can be applied to the oozing of the cavity and other parts with the help of auxiliary equipment, or the doctor can use this product in combination with other commercially available products based on experience , such as hemostatic sponge, hemostatic gauze and other products, so as to achieve better hemostasis effect. ...

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Abstract

The invention provides a hemostatic material as well as a preparation method and application thereof. The hemostatic material is prepared from nanofiber clusters; the nanofiber clusters are derived from a crosslinked nanofiber material and have dimensions within a range of 5mu m to 500mu m in any direction of a three-dimensional space by taking a geometric center of the nanofiber clusters as a starting point; and / or, the dimensions, represented by a median particle size D50, of the nanofiber clusters in the hemostatic material are in a range of 100mu m to 500mu m; the nanofiber clusters respectively have a porous structure, and the nanofiber clusters respectively have a staggered structure formed by overlapping multiple short nanofibers; the diameters of the short nanofibers are in a rangeof 1nm to 1000nm, and the lengths of the short nanofibers are1000mu m or less; the porosity of the hemostatic material is 50-90%. The hemostatic material provided by the invention has excellent tissue adhesion property and a remarkable hemostatic effect; the excellent tissue adhesion property can enable the material to closely adhere to a wound surface during hemostasis, so that the material is prevented from being washed away by blood, the hemostatic effect is significantly improved, and the mutual fusion process of the material and tissues is promoted.

Description

technical field [0001] The invention relates to a hemostatic material and its preparation method and application, belonging to the field of biomedical materials. Background technique [0002] Biomedical materials are a class of high-tech materials developed in the past 30 years, among which hemostatic materials have gradually attracted the attention of the medical community with the increase in accidents such as traffic accidents, severe burns, and major disasters. With the rapid development of modern science and technology, the research on hemostatic materials has made very rapid progress, and various new hemostatic materials have emerged continuously, and their performance has also been greatly improved. Currently, commonly used local hemostatic materials include fibrin glue, thrombin powder, gelatin sponge, collagen sponge, chitosan sponge, oxidized cellulose, microfibrillar collagen, alginate fiber, zeolite, cyanoacrylate, plant polysaccharide powder Wait. Biomedical h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/00A61L24/04
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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