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Medicine for treating non-alcoholic fatty liver disease as well as preparation method and detection method of medicine

A non-alcoholic and detection method technology, which is applied in the field of non-alcoholic simple fatty liver and its preparation, and in the field of drugs for the treatment of fatty liver, which can solve the problem of large toxic and side effects and can not effectively relieve liver histological inflammatory lesions , can not fully control the disease and other problems

Active Publication Date: 2018-02-23
于存国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the main clinical treatment methods are divided into three categories: (1) weight control, the disadvantage is that it is difficult to persist, and the progress of the disease cannot be completely controlled; (2) drug treatment, the disadvantage is that most of the alternative drugs such as thiazolidinediones, lowering Lipid drugs and the like cannot effectively alleviate the inflammatory lesions of liver histology, and the toxic and side effects are large, and most of them have hepatotoxicity; (3) Liver transplantation, the disadvantage is that the cost is high and the recurrence rate is high

Method used

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  • Medicine for treating non-alcoholic fatty liver disease as well as preparation method and detection method of medicine
  • Medicine for treating non-alcoholic fatty liver disease as well as preparation method and detection method of medicine
  • Medicine for treating non-alcoholic fatty liver disease as well as preparation method and detection method of medicine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0334] Prescription: Kozi 200g, Toosendan 200g, Gardenia 200g;

[0335] Preparation:

[0336] (1) After drying Ke Zi, Toosendan, and Gardenia in an oven at 40°C for 4 hours, take the dried Ke Zi, Toosendan, and Gardenia, and use an airflow mill for ultrafine grinding. The air pressure of the machine is 1900kPa, and the feed rate is 240r·min -1, the grading frequency is 35Hz, and the pulverization time is 25min to obtain mixed superfine powder;

[0337] (2) Get the mixed superfine powder of Kozi, Fructus Toosendan and Gardenia obtained in step (1), carry out steam distillation and extraction for 8h, extract volatile oil A therefrom, and set aside; the aqueous solution after steam distillation and extraction is filtered, The filtrate is heated and concentrated to obtain extract B, which is set aside; the medicinal residue extracted by steam distillation is kept, set aside;

[0338] (3) Get the medicinal residues after the steam distillation extraction of step (2) gained, add ...

Embodiment 2

[0357] Prescription: Kozi 200g, Toosendan 200g, Gardenia 200g;

[0358] Preparation:

[0359] (1) After drying Ke Zi, Toosendan, and Gardenia in an oven at 40°C for 4 hours, take the dried Ke Zi, Toosendan, and Gardenia, and use an airflow mill for ultrafine grinding. The air pressure of the machine is 1900kPa, and the feed rate is 240r·min -1 , the grading frequency is 35Hz, and the pulverization time is 25min to obtain mixed superfine powder;

[0360] (2) Get the mixed superfine powder of Kozi, Fructus Toosendan and Gardenia obtained in step (1), carry out steam distillation and extraction for 8h, extract volatile oil A therefrom, and set aside; the aqueous solution after steam distillation and extraction is filtered, The filtrate is heated and concentrated to obtain extract B, which is set aside; the medicinal residue extracted by steam distillation is kept, set aside;

[0361] (3) Get the medicinal residues after the steam distillation extraction of step (2) gained, add...

Embodiment 3

[0365] Embodiment 3: Clinical trial research on non-alcoholic simple fatty liver treated by drug capsules of the present invention

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Abstract

The invention discloses a medicine for treating non-alcoholic fatty liver disease, and belongs to the field of traditional Chinese medicines. The medicine is prepared from the following medicinal rawmaterials in parts by weight: 1 part by weight of fructus chebulae, 1 part by weight of szechwan Chinaberry fruits and 1 part by weight of fructus gardeniae. Based upon animal pharmacological experiments and clinical practices, it is proved that the finished product (the medicine) provided by the invention can take an obvious effect on aspects of improving blood biochemical indexes of the non-alcoholic fatty liver disease, recovering normal weight and fatty liver and the like; the finished product provided by the invention, on the basis of the compatibility of traditional Chinese medicines, not only can achieve a relatively good therapeutic effect but also can reduce toxic and side effects. The technique is supported by scientific and technical key-problem tackling plan project of Hebei Province; and the project is named as research on hepatocyte proliferation and apoptosis influence of precancerous lesion of liver cancer, and the project is numbered as 162777242.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines and relates to a medicine for treating fatty liver, in particular to a medicine for treating nonalcoholic simple fatty liver and a preparation method thereof. Background technique [0002] Nonalcoholic fatty liver disease refers to a clinicopathological syndrome characterized by excessive fat deposition in liver cells caused by alcohol and other definite liver damage factors, and acquired metabolic stress closely related to insulin resistance and genetic susceptibility permanent liver damage. Including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH) and related cirrhosis. With the global prevalence of obesity and its related metabolic syndrome, nonalcoholic fatty liver disease has become an important cause of chronic liver disease in developed countries such as Europe and the United States and in wealthy areas of my country. The prevalence of nonalcoholic fatty liver dis...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P1/16G01N30/02G01N30/06G01N30/14
CPCA61K36/185A61K36/58A61K36/744A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/55G01N30/02G01N30/06G01N30/14G01N2030/065G01N2030/146A61K2300/00
Inventor 于存国王静滨刘金英徐扬王志勇吕鸿
Owner 于存国
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