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Quantitative analysis method for dual adulterated sanqi based on near infrared spectroscopy and stoichiometry

A near-infrared spectroscopy and chemometrics technology, applied in the field of pharmaceutical analysis, can solve problems such as loss, unsatisfactory smoothing and filtering effects, and spectral signal distortion, and achieve the effect of improving accuracy

Inactive Publication Date: 2018-02-16
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Near-infrared spectra of complex samples such as Panax notoginseng are easily affected by test conditions such as temperature, noise and stray light, etc. These factors will reduce the prediction accuracy of the multivariate correction method
The three preprocessing methods of SG smoothing, first-order derivative and second-order derivative all need to determine the window parameters, because the number of windows is too low, the effect of smoothing and filtering noise is not ideal; the number of windows is too high, the smoothing effect becomes better, but it will lose more information, resulting in distortion of the spectral signal

Method used

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  • Quantitative analysis method for dual adulterated sanqi based on near infrared spectroscopy and stoichiometry
  • Quantitative analysis method for dual adulterated sanqi based on near infrared spectroscopy and stoichiometry
  • Quantitative analysis method for dual adulterated sanqi based on near infrared spectroscopy and stoichiometry

Examples

Experimental program
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Effect test

Embodiment 1

[0030] This example is applied to the detection of binary adulterated samples of notoginseng and curcuma, and the quantitative analysis of notoginseng and curcuma in the sample is carried out by using near-infrared spectroscopy and optimal pretreatment combined with PLSR modeling method. The specific steps are as follows:

[0031] 1) Prepare the experimental samples and collect the near-infrared spectra of the samples

[0032] Purchased 25 samples of Panax notoginseng and 28 samples of curcuma in many traditional Chinese medicine stores in Tianjin. The sample was dried at 60° C. for 3 hours in an oven, and then taken out. Grind the dried medicinal materials, pass through a 120-mesh sieve, and store them in a desiccator for future use. The 25 Panax notoginseng samples were classified into three grades of high, medium and low according to the price level. The concentration range of Notoginseng and Curcuma is 0-100%, the interval is 5%, and 3 samples are prepared for each conc...

Embodiment 2

[0047] This example is applied to the detection of binary adulterated data of Panax notoginseng and turmeric. Quantitative analysis of components of Panax notoginseng and turmeric is carried out by using near-infrared spectroscopy and optimal pretreatment combined with PLSR modeling method. The specific steps are as follows:

[0048] 1) Prepare the experimental samples and collect the near-infrared spectra of the samples

[0049] Purchased 25 samples of Panax notoginseng and 28 samples of turmeric in many traditional Chinese medicine stores in Tianjin. The sample was dried at 60° C. for 3 hours in an oven, and then taken out. Grind the dried medicinal materials, pass through a 120-mesh sieve, and store them in a desiccator for future use. The 25 Panax notoginseng samples were classified into three grades of high, medium and low according to the price level. The concentration range of notoginseng and turmeric is 0-100%, the interval is 5%, and 3 samples are prepared for each...

Embodiment 3

[0064] This example is applied to the detection of binary adulterated samples of Panax notoginseng and galangal. The components of Panax notoginseng and galangal are quantitatively analyzed by using near-infrared spectroscopy and optimal pretreatment combined with PLSR modeling method. The specific steps are as follows:

[0065] 1) Prepare the experimental samples and collect the near-infrared spectra of the samples

[0066] Purchased 25 samples of Panax notoginseng and 28 samples of galangal in many traditional Chinese medicine stores in Tianjin. The sample was dried at 60° C. for 3 hours in an oven, and then taken out. Grind the dried medicinal materials, pass through a 120-mesh sieve, and store them in a desiccator for future use. The 25 Panax notoginseng samples were classified into three grades of high, medium and low according to the price level. The concentration range of notoginseng and galangal is 0-100%, the interval is 5%, and 3 samples are prepared for each conc...

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Abstract

The invention relates to a quantitative analysis method for dual adulterated sanqi based on near infrared spectroscopy and stoichiometry. The method comprises: preparing an experimental sample and collecting near infrared spectroscopy of the sample; adopting a grouping manner of integral sequence and local random to divide a data set to a training set and a prediction set; determining an optimum factor number according to variation of RMSECV with the factor number; investigating the pretreatment effect of a SG smoothing method, multiplicative scatter correction, standard normal variables, a first derivative, a second derivative, continuous wavelet transform, and a combination thereof, to obtain an optimal pretreatment method; and adopting the optimal pretreatment method to pre-treat the spectrum, establishing a PLSR model, and predicting an unknown sample. Based on the near infrared spectroscopy and stoichiometry, the method is efficient and lossless, and is fast in detection and highin accuracy. The method is suitable for quantitative analysis of a dual adulterated sanqi sample.

Description

technical field [0001] The invention belongs to the field of pharmaceutical analysis, and in particular relates to a quantitative analysis method for binary adulterated notoginseng based on near-infrared spectroscopy and chemometrics. Background technique [0002] The medicinal value of the Chinese medicinal material Panax notoginseng is extremely high, and it is widely used in various bleeding diseases, blood stasis, bruises, coronary heart disease, angina pectoris, chronic liver disease, migraine, etc., but Panax notoginseng requires at least Three years, thus resulting in a shortage of Sanqi resources and high prices. There are often counterfeit products with similar shapes in the market, such as curcuma, turmeric, galangal and so on. These counterfeit products are mixed with Panax notoginseng, which reduces the curative effect of Panax notoginseng, and even poses a great threat to human health. Therefore, it is of great significance to provide an efficient and accurate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3563
CPCG01N21/359G01N21/3563G01N2201/129
Inventor 刘鹏陈望松张晓卿卞希慧王晓清
Owner TIANJIN POLYTECHNIC UNIV
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