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Preparation method of porous bi-phase calcium phosphate/calcium sulfate composite scaffold for bone tissue engineering

A biphasic calcium phosphate and bone tissue engineering technology, applied in the field of biomedical artificial bone graft materials, can solve the problems of unbearable load, slow degradation rate, non-degradability, etc., achieve the advantage of compressive strength, and promote bone growth. , the effect of degradation rate advantage

Inactive Publication Date: 2018-02-09
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, biphasic calcium phosphate, the most commonly used scaffold material for bone tissue engineering, is a two-phase composite material of β-TCP / HA in different proportions, which has better controllable degradation and osteogenic properties than single calcium-phosphorus ceramic materials, but biphasic calcium phosphate There are certain flaws in the bracket
First, its degradation rate is too slow to match the growth rate of new bone tissue. As far as hydroxyapatite in biphasic calcium phosphate is concerned, it is the most stable in solution and has almost no degradability. It has a certain solubility in the solution and is considered to be a degradable material, but its degradation rate is very slow, generally taking one to two years
Although, different repair sites have different requirements on the degradation performance of materials. For example, craniomaxillofacial bone repair sites generally require scaffold materials to degrade within 3-6 months, while spinal fusion site repairs require scaffold materials to degrade within 9-11 months. Therefore, the degradation rate of a single biphasic calcium phosphate scaffold cannot meet the needs of bone tissue repair
Secondly, the stents prepared from biphasic calcium phosphate have low compressive strength and cannot bear the load, so they cannot be implanted in the body as load-bearing materials.

Method used

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  • Preparation method of porous bi-phase calcium phosphate/calcium sulfate composite scaffold for bone tissue engineering
  • Preparation method of porous bi-phase calcium phosphate/calcium sulfate composite scaffold for bone tissue engineering
  • Preparation method of porous bi-phase calcium phosphate/calcium sulfate composite scaffold for bone tissue engineering

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Embodiment 1

[0024] The preparation method of the porous biphasic calcium phosphate / calcium sulfate composite scaffold described in this embodiment specifically includes the following steps:

[0025] (1) The organic foam carrier with regular through-holes is prepared by laser processing and forming technology, and the organic foam carrier is obtained;

[0026] (2) Mix 5g of distilled water and 10g of silica sol evenly to obtain solution A;

[0027] (3) Mix 5g of biphasic calcium phosphate powder containing 15wt% HA and 85wt% β-TCP with 25g of egg white to obtain slurry B;

[0028] (4) Add solution A to slurry B at a volume ratio of 2:5, and stir with a glass rod to obtain impregnated slurry C;

[0029] (5) Place the organic foam carrier prepared in step (1) in the impregnating slurry and impregnate twice. Each impregnation is heated by a microwave heater at 50°C for 2 minutes, and finally dried in an oven at 50°C for 12 hour, obtain the impregnated green body;

[0030] (6) Place the imp...

Embodiment 2

[0041] The preparation method of the porous biphasic calcium phosphate / calcium sulfate composite scaffold in this embodiment specifically includes the following steps:

[0042] (1) The organic foam carrier with regular through-holes is prepared by laser processing and forming technology, and the organic foam carrier is obtained;

[0043] (2) Mix 5g of biphasic calcium phosphate powder containing 25wt% HA and 75wt% β-TCP with 15g of egg white to obtain slurry B;

[0044] (3) Add 10g of distilled water to the slurry B at a volume ratio of 2:1, and stir with a glass rod to obtain the impregnation slurry C;

[0045] (5) Place the organic foam carrier prepared in step (1) in the impregnating slurry, and impregnate once. Each impregnation is heated by a microwave heater at 30°C for 1min, and finally dried in an oven at 40°C for 6 hour, obtain the impregnated green body;

[0046] (6) Place the impregnated body in a muffle furnace for heat treatment. The heat treatment process is 1°...

Embodiment 3

[0052] The preparation method of the porous biphasic calcium phosphate / calcium sulfate composite scaffold in this embodiment specifically includes the following steps:

[0053] (1) The organic foam carrier with regular through-holes is prepared by laser processing and forming technology, and the organic foam carrier is obtained;

[0054] (2) Mix 10g of distilled water and 20g of silica sol evenly to obtain solution A;

[0055] (3) Mix 5g of biphasic calcium phosphate powder containing 20wt% HA and 80wt% β-TCP with 35g of silica sol to obtain slurry B;

[0056] (4) Add solution A to slurry B at a volume ratio of 2:4, and stir with a glass rod to obtain impregnated slurry C;

[0057] (5) Place the organic foam carrier prepared in step (1) in the impregnating slurry and impregnate three times. Each impregnation is heated by a microwave heater within the range of 50°C for 3min, and finally dried in an oven at 50°C for 12h , to obtain the impregnated green body;

[0058] (6) Pla...

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Abstract

The invention discloses a preparation method of porous bi-phase calcium phosphate / calcium sulfate composite scaffold for bone tissue engineering, and belongs to the field of application of bio-medicalmaterial technologies. The porous composite scaffold is prepared by the following steps: with bi-phase calcium phosphate powder serving as a raw material, adding distilled water and conducting uniformly stirring, so that a dipping slurry is obtained; dipping an organic foam carrier, which is obtained from laser processing and molding, in the slurry, and conducting such processes as microwave heating, drying, heat treatment and the like, so that a porous bi-phase calcium phosphate scaffold that irregular through holes and regular through holes are combined is prepared; and then, dipping the prepared porous bi-phase calcium phosphate scaffold in a calcium sulfate slurry, and conducting hydrating and drying, so that the bi-phase calcium phosphate / calcium sulfate composite scaffold for the bone tissue engineering is finally prepared. The method provided by the invention is simple in process, convenient to operate and stable in yield; the prepared bi-phase calcium phosphate / calcium sulfatecomposite scaffold not only has a porous structure that the irregular through holes and the regular through holes are combined, but also can regulate a degrading rate by adjusting the proportion of the calcium sulfate and the bi-phase calcium phosphate; and the prepared scaffold is qualified in cytotoxicity and good in osteogenesis effect, and the scaffold has a good application prospect.

Description

technical field [0001] The invention relates to a preparation method of a porous biphasic calcium phosphate / calcium sulfate composite scaffold for bone tissue engineering, and belongs to the technical application field of biomedical artificial bone graft materials. Background technique [0002] Tissue engineering, as a multidisciplinary interdisciplinary emerging discipline emerging in recent years, has become a new milestone in the history of life science development, marking that medicine will step out of the scope of organ transplantation and enter a new era of manufacturing tissues and organs. And promote the intersection, penetration and development of related high-tech fields, and thus evolve new high-tech industries. For now, the preparation of ideal scaffolds that fully meet the conditions is one of the important directions in the development of tissue engineering, and rational bone tissue engineering scaffold materials must meet the following basic requirements: (1)...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02A61L27/54A61L27/56
CPCA61L27/025A61L27/12A61L27/54A61L27/56A61L2300/412A61L2430/02A61L2300/112
Inventor 颜廷亭秦晓素陈庆华
Owner KUNMING UNIV OF SCI & TECH
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