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A kind of preparation method of magnetic induction hyperthermia embolization microsphere

A technology of magnetic induction hyperthermia and embolization of microspheres, which is applied in the field of biological and medical micro-nano materials, can solve the problems of decreased effect of embolization hyperthermia and easy metabolism of lipiodol, and achieves excellent heating performance, good biological safety, and broad application prospects. Effect

Active Publication Date: 2020-07-31
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the combination of iodized oil and magnetic fluid as the mainstream embolization and hyperthermia synergy can effectively solve many problems caused by intratumoral injection or intravenous injection of magnetic fluid, but lipiodol is easily metabolized, which leads to a significant decline in the effect of embolization and hyperthermia

Method used

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  • A kind of preparation method of magnetic induction hyperthermia embolization microsphere
  • A kind of preparation method of magnetic induction hyperthermia embolization microsphere
  • A kind of preparation method of magnetic induction hyperthermia embolization microsphere

Examples

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Embodiment 1

[0035] Embodiment 1. Microwave-assisted high-temperature pyrolysis method prepares Fe 3 o 4 nanoparticles

[0036] 1mmol of iron acetylacetonate (Fe(acac) 3 ) into a mixed solvent system containing 8 mL oleylamine (OAm), 2 mL oleic acid (OA) and 6 mL octadecene (ODE). Under the radiation of the maximum microwave output power of 850W, the mixture was rapidly heated from room temperature to 200°C through a rapid heating program and kept for 10 min. Immediately afterwards, continue to heat up to 270°C within 5 minutes and maintain for 15 minutes. Finally, the temperature of the system was lowered to 70° C. within about 3 minutes, and the reaction was completed. After the above five steps, the obtained nanoparticles were repeatedly washed with a mixed solvent of ethanol and acetone to fully remove the residual solvent, and then placed in a vacuum drying oven for drying after magnetic separation.

[0037] figure 1 a is the transmission electron microscope image, the average s...

Embodiment 2

[0038] Example 2. Preparation of magnetic induction hyperthermia embolization microspheres with a size of 100-300 μm

[0039] The 20-50nm Fe prepared by microwave in embodiment 1 3 o 4 (Oil phase) Add 50 μL of surfactant Span 80 to 160 mg of granules, and mix evenly. Subsequently, 22 mL of a prepared 5% oil-soluble degradable high molecular polymer dichloromethane solution was quickly added, and 2 mL of the inner aqueous phase containing 2% PVA was fully stirred by dropwise addition. The W / O colostrum was prepared by high shear emulsification at 20k rpm / min, 9°C constant temperature environment. After the colostrum is obtained, quickly place it in a membrane emulsification syringe pump and add 200 mL of 4% PVA aqueous solution as the external water phase to start emulsification through the membrane. Microspheres with a size of 100-300 μm can be obtained by setting and adjusting the stirring speed between 1200-800 rpm / min and curing in a constant temperature environment of 9...

Embodiment 3

[0041] Example 3. Preparation of biodegradable magnetic induction hyperthermia embolization microspheres with a size of 400-600 μm

[0042] The 20-50nm Fe prepared by microwave in embodiment 1 3 o 4 (Oil phase) Add 100 μL of surfactant Span 80 to 180 mg of granules, and mix well. Subsequently, 18 mL of a prepared 8% oil-soluble degradable high molecular polymer dichloromethane solution was quickly added, and 2 mL of the inner aqueous phase containing 3% PVA was fully stirred by dropwise addition. The W / O colostrum was prepared by high shear emulsification at 22k rpm / min, 7°C constant temperature environment. After the colostrum is obtained, quickly place it in a membrane emulsification syringe pump and add 250 mL of 6% PVA aqueous solution as the external water phase to start emulsification through the membrane. Microspheres with a size of 400-600 μm can be obtained by setting and adjusting the stirring speed between 700-500 rpm / min and curing in a constant temperature envi...

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Abstract

The invention discloses a preparation method of magnetic induction hyperthermia embolism microspheres. The preparation method comprises the following steps of by taking a dissolved matter obtained bydissolving biodegradable high molecular polymers with low transition temperature and super paramagnetic Fe3O4 nano-particles into dichloromethane as an oil phase, Span 80 as a surfactant and an aqueous solution dissolved with polyvinyl alcohol (PVA) as an internal water phase, dropwise adding a water phase in the oil phase under the conditions with low temperature and high shearing to form primaryemulsion; placing the primary emulsion in a membrane emulsification instrument for membrane emulsification under the low temperature condition; forming multiple emulsion in a continuous phase of an external water phase PVA after the primary emulsion permeates a membrane, and performing low-temperature solidification to obtain the magnetic induction hyperthermia embolism microspheres which meet the demand for clinic size. The obtained microspheres are arbitrarily adjustable in size in a range from 100 microns to 1000 microns, can realize rabbit orthotopic liver cancer model embolism hyperthermia under guidance of iconography and have potential application in the interventional hyperthermia field of orthotopic tumors.

Description

technical field [0001] The invention belongs to the field of biological and medical micro-nano materials and technologies, and in particular relates to a preparation method and application of magnetic induction hyperthermia embolization microspheres. Background technique [0002] Superparamagnetic Fe 3 o 4 Due to their high saturation magnetization and good biocompatibility, they are expected to be used in clinical diagnosis and treatment, especially in the fields related to cancer. In terms of tumor treatment, magnetic induction hyperthermia has become a research hotspot in the treatment of malignant tumors due to its advantages of minimally invasive and targeted effects. Studies have shown that compared with mainstream hyperthermia methods such as microwave hyperthermia, radiofrequency hyperthermia, laser ablation, microwave hyperthermia, etc., magnetic induction hyperthermia has better targeting, tissue penetration depth and better Thermal efficiency, thereby reducing ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/16A61K47/34A61P35/00
CPCA61K9/1647A61K41/0052
Inventor 张宇梁一俊顾宁
Owner SOUTHEAST UNIV
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